个人简介
I graduated in 1972 with a BSc in Biophysics from the University of Leeds, where I subsequently did a PhD in X-ray crystallography (1972-1975). I took up my first post-doctoral post in the Biophysics Laboratories at Portsmouth (1975-1979) working on the structure of chromatin, principally using the technique of neutron scattering at the Institut Laue-Langevin in Grenoble.
This was followed by post-doctoral positions at the European Molecular Biology Laboratory, Heidelberg (1979-1983), where I carried out studies of DNA–protein complexes using a wide range of biochemical and biophysical techniques. I subsequently moved to the Department of Chemistry, University of Cambridge (1983-1985) where I carried out pioneering research on the structure of specific DNA sequences, using the technique of X-ray crystallography.
In 1985, I returned to Portsmouth as a Senior Lecturer (and subsequently Reader) in Biophysics. I was appointed to a Chair in Biomolecular Science in 1994. I was a founder member of the Institute of Biomedical and Biomolecular Sciences (IBBS) and was Director from 1999-2011. I was Associate Dean (Research) in the Science Faculty from 1999-2009.
My research interests continue to be in the application of biochemical, biophysical and molecular biological techniques to the study of protein-nucleic acid interacrtions. The major techniques employed include DNA footprinting, EMSA, fluorescence and CD spectroscopy, analytical centrifugation, light scattering, X-ray crystallography, neutron scattering and surface plasmon resonance.
研究领域
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Structure and mechanism of C-proteins that regulate the expression of R-M genes.
DNA structure and gene regulation.
The single stranded DNA binding protein (g5p) of Fd bacteriophage, its interaction with novel G-quartet containing nucleic acid structures and its role in prion capture.
Structural analysis of Type I DNA methyltranferases and restriction endonucleases.
Biophysical Methods.
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