Warburton, Philip - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

Role Lecturer in Medical Microbiology Qualifications 2015: Fellow of the Higher Education Academy (FHEA No.PR085534) 2013: PG Cert. Learning & Teaching in Higher Education. Anglia Ruskin University 2006: PhD Microbiology, "Molecular epidemiology of tetracycline resistance in periodontitis." King's College London 2001: BSc (Hons) Microbiology. University of Central Lancashire Professional membership Fellow of the Higher Education Academy Member of the Microbiology Society Member of the British Society for Antimicrobial Chemotherapy Member of the Society for Applied Microbiology

研究领域

Antibiotic Resistance The World Health Organisation has declared antibiotic resistance as one of the major threats facing public health as bacteria are becoming increasingly resistant to antibiotics of last resort which are critical in the treatment of diseases. My interests are focused on identifying the genetic basis of antibiotic resistance in bacteria, and understanding how this resistance is acquired and maintained in bacteria. Many antibiotic resistance genes are carried on mobile genetic elements, such as plasmids, conjugative transposons and integrative genetic elements, which are able to transfer between different bacteria further disseminating resistance. My investigations include looking at antibiotic resistance in bacteria from both clinical and environmental area which can contribute to hospital-acquired and community-acquired infections, and looking at diversity in the resistance mechanisms and their associated genetic elements. In addition to the research in antibiotic resistance, I also look at novel antimicrobial strategies including identifying novel antimicrobial compounds. Bacterial Diversity Bacteria often live in complex communities that can comprise several hundred different species. Many of these communities are poorly investigated, with limited knowledge on their composition and diversity. My research looks at bacteria community diversity, understanding what bacteria are present and potentially investigating them for novel compounds and enzymes.

近期论文

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Arivaradarajan P, Warburton PJ, Paramasamy G, Nair SP, Allan E & Mullany P 2016 'Identification of an antibacterial protein by functional screening of a human oral metagenomic library (vol 362, fnv142, 2015)' FEMS MICROBIOLOGY LETTERS 363, (1) Author Site , DOI PEARL Warburton PJ, Amodeo N & Roberts AP 2016 'Mosaic tetracycline resistance genes encoding ribosomal protection proteins' JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 71, (12) 3333-3339 Author Site , DOI PEARL Arivaradarajan P, Warburton PJ, Paramasamy G, Nair SP, Allan E & Mullany P 2015 'Identification of an antibacterial protein by functional screening of a human oral metagenomic library' FEMS microbiology letters 362, (18) , DOI PEARL Card RM, Warburton PJ, MacLaren N, Mullany P, Allan E & Anjum MF 2014 'Application of Microarray and Functional-Based Screening Methods for the Detection of Antimicrobial Resistance Genes in the Microbiomes of Healthy Humans' PLOS ONE 9, (1) Author Site , DOI PEARL Warburton PJ, Ciric L, Lerner A, Seville LA, Roberts AP, Mullany P & Allan E 2013 'TetAB(46), a predicted heterodimeric ABC transporter conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity' JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 68, (1) 17-22 Author Site , DOI PEARL Mullany P, Allan E & Warburton PJ 2012 'Tetracycline resistance genes and mobile genetic elements from the oral metagenome' CLINICAL MICROBIOLOGY AND INFECTION 18, 58-61 Author Site , DOI Brouwer MSM, Warburton PJ, Roberts AP, Mullany P & Allan E 2011 'Genetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile' PLOS ONE 6, (8) Author Site , DOI PEARL Warburton PJ, Allan E, Hunter S, Ward J, Booth V, Wade WG & Mullany P 2011 'Isolation of bacterial extrachromosomal DNA from human dental plaque associated with periodontal disease, using transposon-aided capture (TRACA)' FEMS MICROBIOLOGY ECOLOGY 78, (2) 349-354 Author Site , DOI PEARL