Upton, Mathew - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

Role May 2013 - Reader in Medical Microbiology, University of Plymouth April 2014 - Co-founder and Director at Spectromics Ltd (http://www.spectromics.com/) June 2011 - Senior Lecturer in Medical Microbiology, University of Manchester June 2001 - Lecturer in Medical Microbiology, University of Manchester

研究领域

Understanding the inner workings of bacterial pathogens The vast majority of bacteria that live in and on our bodies contribute significantly to our health and well-being. However, sometimes we succumb to bacterial infections and, increasingly, these are becoming harder to treat due to antibiotic resistance. My group focuses on investigation of E. coli strains that cause urinary tract infections, a very common infection that is often mild, but can lead to severe debilitation, or death. The introduction of next generation DNA sequencing technologies has revolutionized the way we examine the mechanisms that pathogenic bacteria use to cause disease or evade the action of antibiotics. By studying their genomes, we aim to understand these bacteria and will be able to develop specific molecular assays for rapid detection and for outbreak investigation. The above work is carried out in collaboration with colleagues at University of Queesnland, Brisbane (Drs Scott Beatson and Makrina Totsika and Prof Mark Schembri) and University of Liverpool (Prof Craig Winstanley). Plugging the gaps in the antibiotic discovery pipeline The WHO have declared that antibiotic resistance is one of the major threats to human health. Very recently, the Chief Medical Officer raised this issue nationally and the topic was even highlighted at the G8 summit in June 2013. However, there is still a real need to discover novel antibiotics. Infections caused by drug resistant pathogens are a significant cause of morbidity and mortality and pan-resistant organisms are becoming less rare. My group runs a programme of natural product screening for discovery of bacteriocins, antimicrobial peptides produced by bacteria. The programme is supported by use of next generation sequencing methods to determine bacterial genome sequences and generate metagenomic datasets that can be interrogated with various software tools for identification of putative bacteriocins.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Halliwell S, Warn P, Sattar A, Derrick JP & Upton M 2016 'A single dose of epidermicin NI01 is sufficient to eradicate MRSA from the nares of cotton rats' The Journal of antimicrobial chemotherapy , DOI Sarkar S, Roberts LW, Phan M-D, Tan L, Lo AW, Peters KM, Paterson DL, Upton M, Ulett GC & Beatson SA 2016 'Comprehensive analysis of type 1 fimbriae regulation in fimB-null strains from the multidrug resistant Escherichia coli ST131 clone' MOLECULAR MICROBIOLOGY 101, (6) 1069-1087 Author Site , DOI PEARL Moat J, Rizoulis A, Fox G & Upton M 2016 'Domestic shower hose biofilms contain fungal species capable of causing opportunistic infection' Journal of Water and Health Morra R, Shankar J, Robinson CJ, Halliwell S, Butler L, Upton M, Hay S, Micklefield J & Dixon N 2016 'Dual transcriptional-translational cascade permits cellular level tuneable expression control' NUCLEIC ACIDS RESEARCH 44, (3) Author Site , DOI PEARL Alghoribi MF, Gibreel TM, Farnham G, Al Johani SM, Balkhy HH & Upton M 2015 'Antibiotic-resistant ST38, ST131 and ST405 strains are the leading uropathogenic Escherichia coli clones in Riyadh, Saudi Arabia' J Antimicrob Chemother 70, (10) 2757-2762 Author Site , DOI Castelino M, Eyre S, Tutino M, Moat J, Martin P, Ijaz U, Quince C, Ho P, Upton M & Barton A 2015 'Bacterial Skin Microbiome in Psoriatic Arthritis (A)over-tildec(a)over-cap, (a)over-cap(sic)oe Pilot Data from Psoriatic Plaques on Dry Skin Sites from Patients with Psoriasis (PsC) and Psoriatic Arthritis (PsA)' ARTHRITIS & RHEUMATOLOGY 67, Author Site Forde BM, Phan M-D, Gawthorne JA, Ashcroft MM, Stanton-Cook M, Sarkar S, Peters KM, Chan K-G, Chong TM & Yin W-F 2015 'Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone' MBIO 6, (6) Author Site , DOI PEARL Phan MD, Forde BM, Peters KM, Sarkar S, Hancock S, Stanton-Cook M, Ben Zakour NL, Upton M, Beatson SA & Schembri MA 2015 'Molecular characterization of a multidrug resistance IncF plasmid from the globally disseminated Escherichia coli ST131 clone' PLoS One 10, (4) Author Site , DOI PEARL Castelino M, Eyre S, Moat J, Fox G, Martin P, Ijaz U, Quince C, Ho P, Upton M & Barton A 2015 'The skin microbiome in psoriatic arthritis: methodology development and pilot data' LANCET 385, 27-27 Author Site