Thompson, Stephen - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

Qualifications 2003-2004 Lecturer. School of Biological Sciences. University of Plymouth. 1999-2003 Lecturer. Division of Physiology & Centre for Neuroscience Research, King’s College London. 1995-1999 MRC Career Development Award Research Fellow Department of Physiology. St. Thomas’ Hospital Medical School (UMDS). London. 1992-1995 Research Fellow. Novartis Institute for Medical Research. London. 1985-1992 Postdoctoral Research Assistant. Department of Anatomy & Developmental Biology. University College London 1982-1985 University of Glasgow, Institute of Physiology, PhD. (Neuroscience) 1978-1982 University of Dundee, Institute of Biomedical Science. BSc. Physiology

研究领域

Research interests focus on the fundamental molecular, cellular and systems mechanisms that underlie dysfunction within the damaged vertebrate central and peripheral nervous systems, its repair mechanisms and regeneration responses. One theme of this work is to understand mechanisms which may contribute to chronic pain states. Another is to investigate mechanisms that underlie impaired regeneration within the injured or diseased central nervous system. The goal of these studies is to promote the re-establishment of normal cell function under circumstances where the physical or metabolic environment may be non-permissive to repair.

近期论文

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M.P. Helley, W. Abate, S.K. Jackson, J.H. Bennett, S.W.N.Thompson (2015). The expression of Toll-like receptors 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglionsensory neurons. Neuroscience. 310. 686-698 ThompsonS.W.N. (2009).Windup in the Spinal cord. In Synaptic Plasticity and Pain. pp. 255-270. Edit. M.Malcagnio. Springer. New York. 2009. Averill,S., Inglis,J.J. King,V.R., Thompson S.W.N., Cafferty, W.B.J.,Shortland,P.J., Hunt S.P, Kidd, B.L. and Priestley,J.V. (2008). Reg-2 expression in dorsal root ganglionneurons after adjuvant-induced monoarthritis. Neuroscience. 155. 1227-1236. Thaker MA., Clark, AK., Bishop T., Grist J., YipPK., Moon LDF., Thompson SWN., Marchand F. and McMahon SB. (2008). CCL2 is akey mediator of microglia activation in neuropathic pain states. European Journal of Pain. 13. (3):263-272. ThompsonS.W.N. (2006). Clinical Pain, Experimental Evidence: Molecular Mechanismswithin the Spinal Cord. In ‘Topical Issues in Pain’ Vol 5. no.6. Pub. ThePhysiotherapy Pain Association. Edit. L.Gifford. CNS Press Ltd. Abdou-Sherif S., Hall, S., Thompson S.W.N. & Hamann, W. (2006).Pulsed radiofrequency applied to dorsal root ganglia causes a selective increasein ATF3 in small neurons European Journalof Pain 10. 171-176. Qiu, J. Cafferty, W.B.J., McMahon,S.B. and S.W.N. Thompson (2005) Conditioning-injuryinduced spinal cord regeneration requires STAT3 activation Journal of Neuroscience 25: 1645-1653. Cafferty,W.B.J., Gardiner, N.J., Das,P., Qiu, J. McMahon,S.B. & Thompson,S.W.N.(2004) Conditioning-Injury induced spinal axon regeneration fails in IL-6Knockout mice. Journal of Neuroscience 24 (18)4432-4443 Slack,S. Pezet, S., McMahon,S.B. Thompson,S.W.N.& Malcagnio,M. (2004) Brain-derived Neurotrophic factor induces NMDAreceptor subunit one phosphorylation via ERK and PKC in the spinal cord. Eur. J.Neurosci.. 20. 1769-1778.