个人简介
Role
Incharge Proteomics Facility
Qualifications
BSc (Hons) Biochemistry, 2001
MSc (Hons) Biochemistry (Research Masters), 2003
PhD (CSIR Fellow), Pharmacology and Toxicology, 2008
研究领域
I am running the Proteomics Core Services Laboratory located within the Systems Biology Facility. We offer various services involving LC-MS Based Proteomics and Bioinformatic Analysis of Proteomic Datasets. Besides this, I also provide specialist advice on experimental designs for a wide range of research projects.
My research primarily focusses on development of customised LC-MS based Proteomic Workflows for a wide range of applications. I have keen interest in epigenetic post translational modifications and their role in disease pathology, Cancer and toxic responses.
近期论文
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Pablo Suárez-Cortés, Vikram Sharma, Lucia Bertuccini, Giulia Costa, Naa-Lamiley Bannerman, Anna Rosa Sannella, Kim Williamson, Michael Klemba, Elena A. Levashina, Edwin Lasonder, Pietro Alano. Comparative proteomics and analysis reveal a role of P. falciparum osmiophilic bodies in malaria parasite transmission. Molecular & Cellular Proteomics. Published on July 18, 2016 as Manuscript M116.060681
Guillaume Bouyer, Luc Reininger, Ghania Ramdani, Lee Phillips, VikramSharma, Stephane Egee, Gordon Langsley, Edwin Lasonder. P.falciparuminfection induces dynamic changes in the erythrocyte phospho-proteome.Blood Cells Molecules and Diseases 58 · February 2016
Zhou L, Lyons-Rimmer J, Ammoun S, Müller J, Lasonder E, Sharma V, Ercolano E, Hilton D,Taiwo I, Barczyk M, Hanemann CO.The scaffold protein KSR1, a novel therapeutictarget for the treatment of Merlin-deficient tumors. Oncogene. 2015 Nov 9. doi: 10.1038/onc.2015.404.
Vikram Sharma* and Kulbhushan Tikoo: Stage SpecificQuantitative Changes in the Renal and Urinary Proteome during the Progressionand Development of Streptozotocin Induced Diabetic Nephropathy in Rats.MolCell Biochem. 2014 Mar;388(1-2):95-111. doi:10.1007/s11010-013-1902-5. Epub 2013 Nov 27 (* Corresponding Author)
Adalberto Costessi, Nawel Mahrour,Vikram Sharma, RiekaStunnenberg,Marieke A Stoel,Esther Tijchon, Joan W Conaway, Hendrik GStunnenberg. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitinligases by the human tumour antigen PRAME. PLoS One. 2012;7(8):e42822.doi:10.1371/journal.pone.0042822. Epub 2012 Aug 13.
Evelien Middeljans, Xi Wan, Pascal W. Jansen, VikramSharma, Hendrik G. Stunnenbergand Colin Logie*. SS18 Together withAnimal-Specific Factors Defines HumanBAF-Type SWI/SNF Complexes. PLoSOne.2012;7(3):e33834. doi:10.1371/journal.pone.0033834. Epub 2012Mar 19
Shahhoseini M, Favaedi R, Baharvand H, Sharma V,Stunnenberg HG. Evidence for a dynamic role of the linkerhistone variant H1xduring retinoic acid-induced differentiation of NT2 cells. FEBS Lett. 2010 Nov19; 584(22): 4661-4.
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