个人简介
PhD University of Edinburgh
BSc (Hons) Queen's University Belfast
PGCAP Plymouth University 2012
研究领域
Investigation of CCN matricellular proteins in normal and malignant haematopoesis and solid tumour metastasis to bone. CCN proteins modulate stem cell signalling pathways including that of transforming growth factor beta, bone morphogenic protein, Notch and Wnt-beta-catenin. Abberations in CCN expression have been associated with a number of haematological malignancies including leukaemia and also in prostate cancer. CCN overexpression and knockdown systems have been created to identify the associated signalling pathways involved in tumourigenesis, advanced and resistant disease using gene array profiling. Identification of novel targeting strategies directed toward CCN associated stem cell signalling will allow development of novel therapeutics to more effectively target cancer.
近期论文
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Burt C, Roddari J, Mindos T, Furtado M, Rule S & McCallum L 2013 'CCN1 modulates cell growth in aggressive mantle cell lymphoma' BRITISH JOURNAL OF HAEMATOLOGY 161, 44-44 Author Site
Yakkundi A, McCallum L, O'Kane A, Dyer H, Worthington J, McKeen HD, McClements L, Elliott C, McCarthy HO & Hirst DG 2013 'The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway' PLoS One 8, (2) Author Site , DOI
McCallum L, Lu W, Price S, Lazar N, Perbal B & Irvine AE 2012 'CCN3 suppresses mitogenic signalling and reinstates growth control mechanisms in Chronic Myeloid Leukaemia' JOURNAL OF CELL COMMUNICATION AND SIGNALING 6, (1) 27-35 Author Site , DOI
Valentine A, O'Rourke M, Yakkundi A, Worthington J, Hookham M, Bicknell R, McCarthy HO, McClelland K, McCallum L & Dyer H 2011 'FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism' Clin Cancer Res 17, (5) 1044-1056 Author Site , DOI
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