Mann, Val - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

Role Associate Professor (Senior Lecturer) Molecular Cell Biology Employability Co-ordinator, School of Biomedical & Healthcare Sciences. Visiting Senior Fellow in Regenerative Medicine, Faculty of Health and Science, University Campus Suffolk. Qualifications BSc (Hons) Biochemistry (1993), University of Aberdeen PhD Medical Sciences (1999), University of Aberdeen Senior Fellow of the Higher Education Academy (2015)

研究领域

My research is focused on understanding the molecular response of bone to mechanical stimulation (exercise) and the role of osteocyte apoptosis in the control of bone remodelling. I am also involved in research in the use of cell therapies for use in regenerative medicine and have experience in the production of clinical grade autologous and allogeneic sourced stem cells and in vivo models of bone and cartilage repair. I am currently undertaking research into the use of assistive technologies for weight management and the design of smart exercise regimens for frail elderly - falls prevention and cognitve decline in dementia syndrome.

近期论文

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Tremoleda JT, Mann V, Racey SN, Khan NS, Wojtacha D, Martin AJ, McWhir J, Simpson AHWR, Noble BS. Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation. J Musculoskelet Neuronal Interact. 2012 Dec;12(4):241-53. Greig CA, Gray C, Rankin D, Young A, Mann V, Noble BS, Atherton PJ Blunting of adaptive responses to reistance training in women aged over 75 years. Exp Gerontol. 2011 Nov 46(11):884-90 Kogianni G*, Mann V* and Noble BS. Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localised bone destruction. Journal of Bone Mineral Research. June 2008 Jun;23(6):915-27. *joint first authorship. David V, Guignandon A, Martin A, Malaval L, Lafage-Proust MH, Rattner A, Mann V, Noble B, Jones DB, Vico L. Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain. Tissue Eng Part A. 2008 Jan;14(1):117-26. Mann V, Huber C, Kogianni G, and Noble B. The Anti-Oxidant Effect of Estrogen and Selective Estrogen Receptor Modulators in the Protection of Osteocytes from Oxidative Stress Induced Cell Death in vitro. Bone. 2007 Mar;40(3):674-84. Mann V, Huber C, Kogianni G, Jones D, Noble B. The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone. J Musculoskeletal Neuronal Interact. 2006 Oct-Dec;6(4):408-17. Stewart TL, Roschger P, Misof BM, Mann V, Fratzl P, Klaushofer K, Aspden R, Ralston SH. Association of COLIA1 Sp1 Alleles with Defective Bone Nodule Formation In Vitro and Abnormal Bone Mineralization In Vivo. Calcif Tissue Int. 2005 May 19.