Madgett, Tracey - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

Qualifications B.A. Hons. Natural Sciences - Cambridge University (Newnham College), 1996 M.A. - Cambridge University, 2000 Ph.D. - The regulation of cyclooxygenase-2 in an in vitro model of colorectal tumorigenesis and mechanisms of action of potential chemopreventive agents. Bristol University, 2000 Post-Graduate Certificate in Academic Practice (PGCAP) - Plymouth University, 2015 Background Prior to joining Plymouth University in 2010, Tracey completed post-doctoral studies at Bath University (2000-2003) and the University of the West of England, Bristol (2003-2010). She became proficient in a variety of laboratory techniques and alongside her own research was able to support undergraduate students during their final year projects. Cancer research made way for blood group genotyping research and then non-invasive prenatal diagnosis research (with the group of Prof Neil Avent). Since arriving in Plymouth, Tracey has managed the day-to-day running of the laboratory of Prof Neil Avent (including supervision of Ph.D. students and undergraduates). In 2011, she was heavily involved in the design of the refurbishment of the laboratories for the Plymouth University Systems Biology Centre (genomics and proteomics facilities) and is now the Director of the Centre.

研究领域

Molecular diagnostics in the fields of transfusion medicine and non-invasive prenatal diagnosis, primarily blood group genotyping (with a particular interest in RHD genetics), free fetal DNA enrichment methods and finding new protein biomarkers for Down Syndrome in maternal plasma. Research focus involves using technologies such as next generation sequencing, digital PCR and mass spectrometry/proteomics (including difference in gel electrophoresis, DIGE).

近期论文

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Sillence KA, Roberts LA, Hollands HJ, Thompson HP, Kiernan M, Madgett TE, Welch CR & Avent ND 2015 'Fetal Sex and RHD Genotyping with Digital PCR Demonstrates Greater Sensitivity than Real-time PCR' Clin Chem 61, (11) 1399-1407 Author Site , DOI PEARL Li B, Pan G, Avent ND, Lowry RB, Madgett TE & Waines PL 2015 'Graphene electrode modified with electrochemically reduced graphene oxide for label-free DNA detection' BIOSENSORS & BIOELECTRONICS 72, 313-319 Author Site , DOI PEARL Sillence KA, Madgett TE, Roberts LA, Overton TG & Avent ND 2013 'Non-Invasive Screening Tools for Down's Syndrome: A Review' Diagnostics (Basel, Switzerland) 3, (2) 291-314 , DOI Haer-Wigman L, Veldhuisen B, Jonkers R, Lodén M, Madgett TE, Avent ND, de Haas M & van der Schoot CE 2013 'RHD and RHCE variant and zygosity genotyping via multiplex ligation-dependent probe amplification' Transfusion 53, (7) 1559-1574 Author Site , DOI Heywood W, Mills K, Wang D, Hogg J, Madgett TE, Avent ND & Chitty LS 2012 'Identification of new biomarkers for Down's syndrome in maternal plasma' J Proteomics 75, (9) 2621-2628 Author Site , DOI Webb A, Madgett T, Miran T, Sillence K, Kaushik N, Kiernan M & Avent N 2012 'Non invasive prenatal diagnosis of aneuploidy: next generation sequencing or fetal DNA enrichment?' Balkan J Med Genet 15, (Suppl) 17-26 Author Site , DOI Heywood W, Wang D, Madgett TE, Avent ND, Eaton S, Chitty LS & Mills K 2012 'The development of a peptide SRM-based tandem mass spectrometry assay for prenatal screening of Down syndrome' J Proteomics 75, (11) 3248-3257 Author Site , DOI Heywood WE, Madgett TE, Wang D, Wallington A, Hogg J, Mills K & Avent ND 2011 '2D DIGE analysis of maternal plasma for potential biomarkers of Down Syndrome' Proteome Sci 9, Author Site , DOI