Lasonder, Edwin - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

Qualifications PhD Medical Sciences, University of Goningen, The Netherlands (1995) Drs Organic Chemistry, University of Groningen, The Netherlands (1990)

研究领域

My general research interest is the application of massspectrometry–based proteomics in biomedical research with a particular interestfor the human diseases malaria and cancer. The most severe form of malaria is caused by the infection of the parasite Plasmodium falciparum when an infected Anopheles mosquito takes a blood meal. Currently, about half of the 5500 P.falciparum genes are not functionally annotated due to poor homology with other species. We apply proteome mining and proteome expression profiling for creating a proteomic catalogue of proteins expressed in all of the life cycle stages. So far,we have characterised about 2600 P.fal proteins across seven developmental life cycle stages in human and mosquito hosts. The most recent work is focussed on establishing the parasite phosphoproteome in infected red blood cells(schizonts, merozoites) to decipher parasite-specific signalling pathways that allow development of new anti-malarial drugs.

近期论文

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Lasonder E, Rijpma SR, van Schaijk BCL, Hoeijmakers WAM, Kensche PR, Gresnigt MS, Italiaander A, Vos MW, Woestenenk R & Bousema T 2016 'Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression' NUCLEIC ACIDS RESEARCH 44, (13) 6087-6101 Author Site , DOI PEARL Bouyer G, Reininger L, Ramdani G, Phillips LD, Sharma V, Egee S, Langsley G & Lasonder E 2016 'Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome' BLOOD CELLS MOLECULES AND DISEASES 58, 35-44 Author Site , DOI PEARL Eich C, Lasonder E, Cruz LJ, Reinieren-Beeren I, Cambi A, Figdor CG & Buschow SI 2016 'Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells' PLOS ONE 11, (2) Author Site , DOI PEARL Worah K, Mathan TSM, Manh TPV, Keerthikumar S, Schreibelt G, Tel J, Duiveman-de Boer T, Skold AE, van Spriel AB & de Vries IJM 2016 'Proteomics of Human Dendritic Cell Subsets Reveals Subset-Specific Surface Markers and Differential Inflammasome Function' CELL REPORTS 16, (11) 2953-2966 Author Site , DOI PEARL Zhou L, Lyons-Rimmer J, Ammoun S, Mueller J, Lasonder E, Sharma V, Ercolano E, Hilton D, Taiwo I & Barczyk M 2016 'The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors' ONCOGENE 35, (26) 3443-3453 Author Site , DOI PEARL Middelbeek J, Vrenken K, Visser D, Lasonder E, Koster J, Jalink K, Clark K & van Leeuwen FN 2016 'The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression' EUROPEAN JOURNAL OF CELL BIOLOGY 95, (11) 465-474 Author Site , DOI PEARL Lasonder E, Green JL, Grainger M, Langsley G & Holder AA 2015 'Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparum schizonts develop into extracellular invasive merozoites' Proteomics 15, (15) 2716-2729 Author Site , DOI