Jarvis, Michael - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

A native Californian, Ireceived my PhD in Biochemistry and Molecular Biology from the University ofCalifornia at Davis in 1996. With >16 years experience in cytomegalovirus(CMV) biology and the use of state-of-the-art bacterial artificial chromosome (BAC)technology, I am regarded as a leading expert in the construction andcharacterization of recombinant viral vectors for prophylactic and therapeuticvaccination against infectious disease and cancer. Until 2012, I was a memberof a large multi-laboratory effort at Oregon Health & Sciences University focusedon development of a CMV-based HIV vaccine using the simian immunodeficiencyvirus (SIV) rhesus macaque model of AIDS. These studies addressing an importantsocietal problem resulted in a number of high-profile publications in Nature,Nature Medicine and Science. I moved to the University of Plymouth in Spring of2012, where I am currently an Associate Professor (Reader) in Virology &Immunology. I regard myself as a virologist who utilizes immunology, and overthe years have enjoyed acquiring the immunological expertise necessary toexamine and understand the immunology behind the vectors. I find the innovativeaspect of science particularly exciting, and development of imaginativestrategies for the use of these vectors underpins my research. My move toPlymouth has given me the necessary intellectual freedom to focus on projectsthat I initiated at OHSU, as well as to pursue new paths of interest.

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Murthy S,Couacy-Hymann E, Metzger S, Nowak K, De Nys H, Boesch C, Wittig R, Jarvis MA, Leendertz FH, Ehlers B. 2013. Absence of Frequent Herpesvirus Transmission in aNon-human Primate Predator-Prey System in the Wild. J Virology.87:10651 Scuda N, Madinda NF, Akoua-Koffi C,Adjogoua EV, Wevers D, Hofmann J, Cameron KN, Leendertz SAJ, Couacy-Hymann E, RobbinsM, Boesch C, Jarvis MA, Moens U, Mugisha L, Calvignac-Spencer S, LeendertzFH, Ehlers B. 2013. NovelPolyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for theExistence of Multiple Unknown Polyomaviruses within the Human Population. PloSPathogens 9:e1003429 Dekhtiarenko I, Jarvis MA, RuzsicsZ, Cicin-Sain L. 2013. The Context of Gene Expression Defines the Immunodominance Hierarchy ofCytomegalovirus Antigens. J Immunol. 190:3399 Klyushnenkova EN, Kouiavskaia DV, CaposioP, Boto S, Alexander RB, and Jarvis MA. 2012. A cytomegalovirus basedvaccine designed to enhance tumor-specific CD8+ T cells results in tumorregression in a murine model of prostate cancer. J Immunotherapy 35:390. Tierney R, Nakai T, Parkins CJ, Caposio P,Fairweather NF, Sesardic D, Jarvis MA. 2012. A single-dose cytomegalovirus-based vaccine encoding a tetanustoxin fragment C induces sustained levels of protective tetanus antibodies inmice. Vaccine 30:3047. Tsuda, Y, Caposio P, Parkins C, Botto S,Messaoudi I, Cicin-Sain L, Feldmann H, Jarvis MA. 2011. A replicatingcytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTLepitope confers protection against lethal Ebola virus challenge. Plos Negl.Trop. Dis. 5:e1275. 7. Hansen SG, Ford JC, Lewis MS, Ventura AB,Hughes CM, Coyne-Johnson L, Whizin N, Oswald K, Shoemaker R, Swanson T, LegasseAW, Axthelm MK, Nelson JA, Jarvis MA, Piatak, Jr M, Lifson JD, PickerLJ. 2011. Profound early control of highly pathogenic SIV by an effector-memoryT cell vaccine. Nature. 473:523. Hansen, SG, Powers C,Richards R, Ventura AB, Ford JC, Siess D, Axthelm MK, Nelson JA, Jarvis MA, Picker LJ, Früh K. 2010. Evasion of CD8+ T cells is critical forsuper-infection by cytomegalovirus. Science 328:102. Wille PT, Knoche AJ, NelsonJA, Jarvis MA, Johnson DC. 2010. A human cytomegalovirus gO-null mutantfails to incorporate gH/gL into the virion envelope and is unable to enterfibroblasts and epithelial and endothelial cells. J Virology 84:2585. Dutia BM, Reid SJ, Drummond DD, Ligertwood Y, Bennet I, Rietberg W, Silvia O, Jarvis MA, Nash AA. 2009. A novel Cre recombinase imaging system for trackinglymphotropic virus infection in vivo. PloS One. 4:e6492.