Jackson, Simon - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

2005 – 2010: Professor of Molecular Immunology, and Director, Centre for Research in Biomedicine, Faculty of Health and Life Sciences, University of the West of England, Bristol 2003-2005: Director of Research, Department of Medical Microbiology, School of Medicine, Cardiff University, 1994 – 2003: Senior Lecturer, Department of Medical Microbiology, University of Wales College of Medicine, 1993 -1994: Visiting Scientist, Dartmouth Medical School, Dartmouth College, USA 1987- 1993: Lecturer, Department of Medical Microbiology, University of Wales College of Medicine, Cardiff.

研究领域

My research activities are centred on immunological and inflammatory responses to infection and in particular responses to bacterial lipopolysaccharide (LPS; endotoxin) and related molecular species. Better understanding of such mechanisms will help to develop therapies for severe infectious conditions such as sepsis that carry a high mortality. My group has identified links between lipid modifying enzymes (lysophospholipid acyltransferases) that control cell membrane composition and leukocyte signalling responses to LPS and other Toll-like receptor (TLR) ligands. Current work is utilising gene knockdown to identify specific roles for these enzymes in the innate immune response to infection to aid development of new therapeutic and diagnostic approaches. Recently, with collaborators in Birmingham, Nottingham and Cambridge, we have developed novel nano-electrode-cell constructs to identify highly resolved spatial and temporal reactive oxygen (ROS) signalling events in response to LPS in single cells. We are also interested in how inflammatory responses can be amplified by interactions of the signalling pathways with environmental/exogenous molecules and we have established new cell models to explore these effects. These include 3D cell cultures (spheroids) that are more representative of cells and tissues in vivo . The cell culture models are part of our agenda to reduce or replace animals in research (3Rs).

近期论文

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Kanyong P, Hughes G, Pemberton RM, Jackson SK & Hart JP 2016 'Amperometric Screen-Printed Galactose Biosensor for Cell Toxicity Applications' ANALYTICAL LETTERS 49, (2) 236-244 Author Site , DOI Langan LM, Dodd NJF, Owen SF, Purcell WM, Jackson SK & Jha AN 2016 'Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry' PLOS ONE 11, (2) Author Site , DOI Rawson FJ, Cole MT, Hicks JM, Aylott JW, Milne WI, Collins CM, Jackson SK, Silman NJ & Mendes PM 2016 'Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes' SCIENTIFIC REPORTS 6, Author Site , DOI Rawson FJ, Hicks J, Dodd N, Abate W, Garrett DJ, Yip N, Fejer G, Downard AJ, Baronian KHR & Jackson SK 2015 'Fast, Ultrasensitive Detection of Reactive Oxygen Species Using a Carbon Nanotube Based-Electrocatalytic Intracellular Sensor' ACS APPLIED MATERIALS & INTERFACES 7, (42) 23527-23537 Author Site , DOI Lilley E, Armstrong R, Clark N, Gray P, Hawkins P, Mason K, López-Salesansky N, Stark A-K, Jackson SK & Thiemermann C 2015 'Refinement of animal models of sepsis and septic shock' Shock 43, (4) 304-316 Author Site , DOI