Green, Elaine - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

Role 2013 – present; Reader, University of Plymouth

研究领域

My research focuses on the genetic architecture of psychiatric and neurological disorders, in particular bipolar disorder. Such complex disorders are highly polygenic and thousands of genetic variants are likely to be causing susceptibility to these disorders. We study both common and rare genetic variants, including single nucleotide polymorphism and structural variants such as copy number variations, and more recently retrotransposons. In collaboration with Cardiff University through the National Centre of Mental Health (www.ncmh.info) we have access to large samples and datasets including vast phenotype information which allows us to study subsets of the bipolar sample, such as postpartum psychosis, schizoaffective disorder and co-morbid migraine

近期论文

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Green EK, Rees E, Walters JTR, Smith K-G, Forty L, Grozeva D, Moran JL, Sklar P, Ripke S & Chambert KD 2016 'Copy number variation in bipolar disorder' Mol Psychiatry 21, (1) 89-93 Author Site , DOI PEARL Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA, Chambert KD, Moran JL & Gordon-Smith K 2016 'Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder' MOLECULAR PSYCHIATRY 21, (9) 1290-1297 Author Site , DOI PEARL Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Castro Giner F, Peppelenbosch MP, Kovac M, Adams CL & Prenen H 2015 'Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus' Gastroenterology 148, (2) 367-378 Author Site , DOI O'Dushlaine C, Rossin L, Lee PH, Duncan L, Parikshak NN, Newhouse S, Ripke S, Neale BM, Purcell SM & Posthuma D 2015 'Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways' NATURE NEUROSCIENCE 18, (2) 199-209 Author Site , DOI Rees E, Kirov G, Sanders A, Walters JTR, Chambert KD, Shi J, Szatkiewicz J, O'Dushlaine C, Richards AL & Green EK 2014 'Evidence that duplications of 22q11.2 protect against schizophrenia' Mol Psychiatry 19, (1) 37-40 Author Site , DOI