Gilpin, Martyn - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

Lecturer in Molecular Genetics, University of Plymouth (1990 - present) NAB Research Fellow, Plymouth Polytechnic (1988-1990). Bacterial Diseases of fish. Research Fellow, Dental Research Unit of the Hunterian Institute, Royal College of Surgeons of England, University of London. MRC funded (1984-87). “Cloning & Characterisation of Genes for Sucrose Metabolism from the Streptococcus mutans group of Cariogenic Bacteria” Ph.D in Microbial Genetics, University of Reading (1980 -1983). Genetic Analysis of Natural Variation in Escherichi coli” SERC Studentship. B.Sc (Hons) in Microbiology, University of Surrey (1977 -1980) Medical Microbiology pathway.

研究领域

Molecular basis of the pathogenicity of bacterial pathogens. Molecular detection and typing systems for bacterial pathogens particularly with repect to the fish pathogen Renibacterium salmoninarum (Bacterial Kidney Disease), the human and animal pathogen Burkholderia pseudomallei (Mellioidosis) and the food poisoning agent Vibrio parahaemolyticus. More recent work has focused on the possible involvement of microbes in the development of human forms of diabetes. In particular: 1) The association Burkholderia cepacia group organisms with the development of diabetes in cystic fibrosis patients, and 2) The possibility that Escherichia coli antigens show cross reactivity with human insulin producing beta-pancreatic cells, leading to possible autoimmune disease.

近期论文

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Nisr, R. B., Moody, A. J., & Gilpin, M. L. (2011). Molecular mimicries of linear epitopes between pancreatic glutamic acid decarboxylase (GAD65) and proteins from Escherichia coli. In IMMUNOLOGY Vol. 135 (pp. 140). Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000297507100422&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 Nisr, R. B., Moody, A. J., & Gilpin, M. L. (2012). Screening microorganisms for insulin binding reveals binding by Burkholderia multivorans and Burkholderia cenocepacia and novel attachment of insulin to Aeromonas salmonicida via the A-layer.. FEMS Microbiol Lett, 328(2), 93-99. doi:10.1111/j.1574-6968.2011.02484.x Nisr, R. B., Russell, M. A., Chrachri, A., Moody, A. J., & Gilpin, M. L. (2011). Effects of the microbial secondary metabolites pyrrolnitrin, phenazine and patulin on INS-1 rat pancreatic β-cells.. FEMS Immunol Med Microbiol, 63(2), 217-227. doi:10.1111/j.1574-695X.2011.00844.x Kadhim, H. M., Miah, A., Munn, C. B., & Gilpin, M. L. (2012). Development of a polymerase chain reaction (PCR) test for the detection of virulent forms of Vibrio parahaemolyticus.. Eur J Clin Microbiol Infect Dis, 31(4), 431-439. doi:10.1007/s10096-011-1324-9 GRAYSON, T., EVENDEN, A., GILPIN, M., & MUNN, C. (1995). PRODUCTION OF A RENIBACTERIUM-SALMONINARUM HEMOLYSIN FUSION PROTEIN IN ESCHERICHIA-COLI K12. DISEASES OF AQUATIC ORGANISMS, 22(2), 153-156. doi:10.3354/dao022153 GRAYSON, T., EVENDEN, A., GILPIN, M., & MUNN, C. (1995). PRODUCTION OF THE MAJOR SOLUBLE-ANTIGEN OF RENIBACTERIUM-SALMONINARUM IN ESCHERICHIA-COLI K12. DISEASES OF AQUATIC ORGANISMS, 22(3), 227-231. doi:10.3354/dao022227 GRAYSON, T., BRUNO, D., EVENDEN, A., GILPIN, M., & MUNN, C. (1995). IRON ACQUISITION BY RENIBACTERIUM-SALMONINARUM - CONTRIBUTION OF IRON REDUCTASE. DISEASES OF AQUATIC ORGANISMS, 22(2), 157-162. doi:10.3354/dao022157 Grayson, T. H., John, R. J., Wadsworth, S., Greaves, K., Cox, D., Roper, J., . . . Harris, J. E. (1995). Immunization of Atlantic salmon against the salmon louse: Identification of antigens and effects on louse fecundity. In JOURNAL OF FISH BIOLOGY Vol. 47 (pp. 85-94). doi:10.1111/j.1095-8649.1995.tb06046.x