Foey, Andrew - Plymouth University - School of Biomedical and Healthcare Sciences

个人简介

School of Biomedical & Biological Sciences Safety Officer (2009-2016) Pathway lead: Infection & Immunity (2010-date) Member of Biomedical Research Governance Sub-committee (CRTB, SoBHCS, PUPSMD) (2013-2016) School Admissions Tutor (2014-2016 - 3 recruitment cycles) School Teaching & Learning Committee member (2014-date) Programme Lead, BSc (Hons) Human Biosciences (2016-date) Qualifications 2007 Fellow of the Higher Education Academy (FHEA No.32432). 2006 PG Cert. Learning & Teaching in Higher Education. University of Plymouth. 1996 PhD "Modulation of pro-inflammatory cytokine expression by intracellular cations." University of Bath. 1989 B.Sc. (Hons.) Applied Biological Sciences. Bristol Polytechnic. 1986 HND Applied Biology. Bristol Polytechnic.

研究领域

Macrophages are fundamental cells to innate immune mechanisms. They exist in two main subsets which are determined by the tissue environment; where both differentiation and activation signals play a role in determining subset effector functionality. M1-like macrophages are pro-inflammatory and display anti-tumour effects whereas the M2-like macrophage subset is anti-inflammatory, regulatory and pro-tumoural. It is unclear whether these two subsets represent distinct canonical forms of macrophage subset or whether there is a sliding scale of effector function between these two extremes. If the latter scenario exists, it is likely that the macrophages display a level of plasticity, hence macrophage function can be manipulated/controlled. The regulation of macrophage function represents a realistic cell-based therapeutic regimen and would be of benefit in the treatment of many diseases where the immunopathological mechanisms are predominated by dysfunctional macrophages. The focus of this research has centred on the role of mucosal macrophages in driving homeostatic healthy immune function and immunopathological mechanisms upon disruption of mucosal tolerance. The disease states currently under investigation include oral pathologies (chronic periodontitis, oral squamous cell carcinoma) and gastro-intestinal tract pathologies (Crohn’s disease, ulcerative colitis). Harnessing of both microbial (commensal and pathological) and dietary effects will allow for the regulation of macrophage function and may ameliorate the symptoms of such pro-inflammatory and suppressive disease states. Current avenues of research endeavour include: 1) Immunomodulatory role of probiotics – centred around the modulation of pro-inflammatory and anti-inflammatory cytokine production by specific macrophage subsets and upon contact-mediated interaction with gut epithelial cells. 2) Mechanisms of endotoxin tolerance mediated by oral pathogens and the relative subset sensitivities to tolerance-induction. 3) Application of oral pathogens and their PAMPs in immune-deviation in pro-inflammatory and suppressive immunopathologies. 4) Negative regulation and manipulation of macrophage plasticity in Crohn’s disease. 5) Immune cell cross-talk mechanisms involved in perpetuation of mucosal pathologies. 6) Role of oligosaccharides/b-glucans as modulators of macrophage-mediated immunity. 7) Dietary microparticles: immune activators or tolerance inducers?

近期论文

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Foey, A.D., Habil, N., Al-Shaghdali, K. and Crean, S.J. (2017): Porphyromonas gingivalis-stimulated macrophage subsets exhibit differential induction and responsiveness to interleukin-10. Archives of Oral Biology 73:282-288. [Citations: x, JIF: 1.733, Doi: 10.1016/j.archoralbio.2016.10.029]. Al-Shabany, A.J., Moody, A.J., Foey, A.D. and Billington, R.A. (2016): Intracellular NAD+ levels are associated with LPS-induced TNFα release in pro-inflammatory macrophages. Bioscience Reports 36(1):e00301. [Citations:3, JIF: 2.637]. Foey, A.D. (2015): Macrophages: Tissue-resident determinants of immunomodulation. Immunotherapy: Open Access 1: 1-3. Standen, B., Peggs, D., Rawling, M., Foey, A., Davis, S., Santos, G. and Merrifield, D. (2016): Dietary administration of a commercial mixed-species probiotic improves growth performance and modulates the intestinal immunity of tilapia, Oreochronis niloticus. Fish & Shellfish Immunology 49:427-435. [Citations: 1, JIF: 2.67, Doi:10.1016/j.fsi.2015.11.037]. Foey, A.D. (2015): Macrophage polarisation: a collaboration of differentiation, activation and pre-programming? Journal of Clinical & Cellular Immunology. 6:293. [Citations:2, JIF: 3.146, Doi:10.4172/2155-9899.1000293]. Habil, N., Abate Woldie, W., Beal, J. and Foey, A.D. (2014): Heat killed probiotic bacteria differentially regulate colonic epithelial cell production of human beta-defensin-2: dependence on inflammatory cytokines. Beneficial Microbes 5(4):483-495. [Citations: 7, JIF: 3.301, Doi:10.3920/BM2013.0061]. Foey, A.D. (2014): Macrophages: masters of immune activation, suppression and deviation. In. Immunostimulation. Ed. Duc, H.T. Chapter 5, pp. 121-149. Publishers: InTech Europe, Croatia. ISBN 980-953-307-1094-2. [Citations: 2]. Foey, A.D. and Crean, S.J. (2013): Macrophage subset sensitivity to endotoxin tolerisation by Porphyromonas gingivalis. PLoS ONE 8(7):e67955 [Citations: 12, JIF: 4.100, Doi:10.1371/journal.pone.0067955]. Hardy, H., Harris, J., Lyon, E., Beal, J. and Foey, A.D. (2013): Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. (Special issue: Nutrients & Immune function). Nutrients 5(6): 1869-1912. [Citations: 98, JIF: 3.270, Doi:10.3390/nu5061869].