Parkinson, David - Plymouth University

研究领域

My research interest in the control of myelination and repair in the peripheral nervous system (PNS). The PNS is myelinated by Schwann cells which ensheathe and myelinate the large caliber axons and allow rapid (saltatory) conduction of nerve impulses. I have studied the transcription factor Krox-20 and how this protein co-ordinates the proliferation, survival and myelination of Schwann cells. My lab also researches what underlies the remarkable ability of Schwann cells to regenerate and repair injury in the peripheral nervous system and how proteins such as c-Jun, Sox-2 and the Merlin tumour suppressor facilitate this repair and cell plasticity.

近期论文

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Schulz A, Buettner R, Hagel C, Baader SL, Kluwe L, Salamon J, Mautner V-F, Mindos T, Parkinson DB & Gehlhausen JR 2016 'The importance of nerve microenvironment for schwannoma development' ACTA NEUROPATHOLOGICA 132, (2) 289-307 Author Site , DOI PEARL Roberts SL, Dun X-P, Dee G, Gray B, Mindos T & Parkinson DB 2016 'The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair' Journal of neurochemistry , DOI Dun X-P & Parkinson DB 2015 'Visualizing peripheral nerve regeneration by whole mount staining' PLoS One 10, (3) Author Site , DOI PEARL Plotkin SR, Albers AC, Babovic-Vuksanovic D, Blakeley JO, Breakefield XO, Dunn CM, Evans DG, Fisher MJ, Friedman JM & Giovannini M 2014 'Update from the 2013 International Neurofibromatosis Conference' AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164, (12) 2969-2978 Author Site , DOI Shivane A, Parkinson DB, Ammoun S & Hanemann CO 2013 'Expression of c-Jun and Sox-2 in human schwannomas and traumatic neuromas' HISTOPATHOLOGY 62, (4) 651-656 Author Site , DOI Doddrell RDS, Dun X-P, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO & Parkinson DB 2013 'Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells' Brain 136, (Pt 2) 549-563 Author Site , DOI PEARL Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C & Mautner V-F 2013 'Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy' NATURE NEUROSCIENCE 16, (4) 426-U86 Author Site , DOI Kim HA, Mindos T & Parkinson DB 2013 'Plastic Fantastic: Schwann Cells and Repair of the Peripheral Nervous System' STEM CELLS TRANSLATIONAL MEDICINE 2, (8) 553-557 Author Site , DOI Yang DP, Kim J, Syed N, Tung Y-J, Bhaskaran A, Mindos T, Mirsky R, Jessen KR, Maurel P & Parkinson DB 2012 'p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination' J Neurosci 32, (21) 7158-7168 Author Site , DOI