Luo, Shouqing - Plymouth University

个人简介

Role Apr 2013-present Associate Professor in Neurobiology Plymouth University Peninsula School of Medicine and Dentistry Qualifications Mar 2009-Apr 2013 Senior Research Fellow Cambridge Institute for Medical Research University of Cambridge, UK Dec 2001-Feb 2009 Research Fellow Cambridge Institute for Medical Research University of Cambridge, UK May 2000-Dec 2001 Postdoctoral Research Associate Northwestern University Medical School, USA Aug 1999-May 2000 Research Fellow National Institute of Child Health and Human Development National Institutes of Health (NIH), USA PhD, Peking Union Medical College & Chinese Academy of Medical Sciences, China (1999) Professional membership British Society of Biochemistry

研究领域

Macroautophagy or autophagy is an intracellular bulk degradation system mediated by lysosomes. Autophagy substrates include long-lived cytosolic proteins, intracellular pathogens and damaged organelles. Autophagosomes are then fused to lysosomes and the contents of autophagosomes are degraded by lysosomal hydrolases, and the resulting degraded components are reused for anabolic and catabolic processes. Autophagy is involved in many biological processes of normal physiology, such as mitigating metabolic stress, degradation of aggregate-prone proteins (e.g, mutant huntingtin), tissue homeostasis, and defects in autophagy process are associated with numerous pathophysiologies, including neurodegenerative diseases and tumorigenesis. The research in our lab currently focuses on autophagy regulation and its roles in Huntington's Disease.

近期论文

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Button RW, Vincent JH, Strang CS and Luo S*. Dual PI-3 kinase/mTOR Inhibition Impairs Autophagy Flux and Induces Cell Death Independent of Apoptosis and Necroptosis. Oncotarget, 2016, DOI: 10.18632/oncotarget.6986. *: corresponding author Luo S*. Apoptosis Blocks Beclin 1-Dependent Autophagosome Synthesis. In Hayat, M.A.ed. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging (Vol 8). Elsevier, pp.101-112, 2015. *: corresponding author Button RW, Luo S*, Rubinsztein DC*. Autophagic activity in neuronal cell death. Neurosci Bull. 31(4): 382-394, 2015. *: corresponding author Button RW, Lin F, Ercolano E, Vincent JH, Hu B, Hanemann CO, Luo S*. Artesunate induces necrotic cell death in schwannoma cells. Cell Death and Disease doi:10.1038/cddis.2014.434, 2014. *: corresponding author Lin F, Ghislat G, Luo S, Renna M, Siddiqi F, Rubinsztein DC. XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NF?B activation. Hum Mol Genet. 24:2899-913, 2015. Toh PP, Luo S, Menzies FM, Rasko T, Wanker EE, Rubinsztein DC. Myc inhibition impairs autophagosome formation. Hum Mol Genet. 22(25):5237-48, 2013. Wu J, Jiang H, Luo S, Zhang M, Zhang Y, Sun F, Huang S, Li H. Caspase mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope. Cell Research. 23(5):691-704, 2013. Luo S and Rubinsztein DC. BCL2L11/BIM: a novel molecular link between autophagy and apoptosis. Autophagy. 9(1):104-5, 2013. Luo S, Garcia-Arencibia M, Zhao R, Puri C, Toh PPC, Sadiq O, Rubinsztein DC. Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Molecular Cell. 47(3):359-70, 2012 (highlighted in Nat Rev Mol Cell Biol, 23;13(8):479, 2012). Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O'Kane CJ, Rubinsztein DC. Complex inhibitory effects of nitric oxide on autophagy. Molecular Cell. 43(1):19-32, 2011.