Felmlee, Daniel - Plymouth University

个人简介

Role Academic Lecturer in Hepatology Qualifications PhD Molecular Biology, University of Colorado Medical School Thesis Title: Hepatitis C alters lipid and lipoprotein metabolism Hepatits C virus (HCV) infection is a major health problem and the leading indication for liver transplantation in the US and Europe. HCV infection associates with disorders in lipid and lipoprotein metabolism including hepatic steatosis, an accumulation of fat in the liver. My previous work at University of Colorado School of Medicine, then University of California, San Diego focused on how HCV replication changes lipoprotein secretion from hepatoma cell lines, leading to lipid accumulation. Following my interest in virus-host interactions of viral hepatitis, I pursued an MRC postdoc position in Newcastle upon Tyne investigating HCV virus/lipoprotein hybrid particles, lipoviral particles (LVP). I developed and collaboratively executed clinically based experiments that revealed LVPs to be dynamic transient particles dependent on host lipoprotein metabolism and external factors such as diet. I then pursued and won a competitive fellowship from European Association for Study of the Liver (EASL) in Strasbourg, France. I used state-of-the-art molecular virology techniques using tissue culture models of HCV infection to further investigate functional relevance of lipoprotein and apolipoprotein interactions for viral entry and escape from host humoral defences. Professional membership Editorial Board Member, World Journal of Hepatology Reviewer, Journal of Infectious Diseases Reviewer, Virology

研究领域

Hepatitis C virus (HCV) infection is a major health problem with 3% of the global population infected. The natural history of HCV typically involves chronic infection resulting in hepatitis, fibrosis, cirrhosis, and end stage liver disease. A number of individuals who through risk factors or known exposure have been exposed to the virus, but neither have HCV RNA detectable in serum nor detectable anti-HCV antibodies. These exposed yet uninfected patients (EUs) appear to have either robust immune defences or other uncharacterized resistance to HCV infection. In the course of genome analysis of these individuals, we have identified candidate genes that are highly associated with HCV resistance. I seek to further characterize these genes through functional analysis using tissue culture HCV replication models.

近期论文

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Verrier ER, Colpitts CC, Bach C, Heydmann L, Weiss A, Renaud M, Durand SC, Habersetzer F, Durantel D & Abou-Jaoudé G 2016 'A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses' Hepatology 63, (1) 35-48 , DOI Fauvelle C, Felmlee DJ, Crouchet E, Lee J, Heydmann L, Lefevre M, Magri A, Hiet M-S, Fofana I & Habersetzer F 2016 'Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies' GASTROENTEROLOGY 150, (1) 206-+ Author Site , DOI Felmlee DJ & Baumert TF 2016 'CD147 handles lipid: a new role for anti-cancer target' TRANSLATIONAL CANCER RESEARCH 5, (3) 238-240 Author Site , DOI Bassendine MF, Nielsen SU, Bridge SH, Felmlee DJ, Sheridan DA, Packard CJ & Neely RD 2016 'Hepatitis C virus and atherosclerosis: A legacy after virologic cure?' Clinics and research in hepatology and gastroenterology , DOI Felmlee DJ, Coilly A, Chung RT, Samuel D & Baumert TF 2016 'New perspectives for preventing hepatitis C virus liver graft infection' LANCET INFECTIOUS DISEASES 16, (6) 735-745 Author Site Ahmed A & Felmlee DJ 2015 'Mechanisms of Hepatitis C Viral Resistance to Direct Acting Antivirals' VIRUSES-BASEL 7, (12) 6716-6729 Author Site , DOI Sheridan DA, Gomez Romero M, Bridge S, Crossey M, Shawa IT, Neely D, Felmlee D, Holmes E, Bassendine M & Taylor-Robinson S 2015 'P0725 : Lipidomics analysis of fasting serum identifies novel lipid biomarkers specific for HCV genotype 3 and genotype 1 chronic hepatitis C virus infection' Journal of Hepatology 62, S596-S596 , DOI Bridge SH, Sheridan DA, Felmlee DJ, Crossey MME, Fenwick FI, Lanyon CV, Dubuc G, Seidah NG, Davignon J & Thomas HC 2015 'PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: Evidence for genotype-specific regulation of lipoprotein metabolism' JOURNAL OF HEPATOLOGY 62, (4) 763-770 Author Site , DOI PEARL Sheridan DA, Bridge SH, Crossey MME, Felmlee DJ, Thomas HC, Neely RDG, Taylor-Robinson SD & Bassendine MF 2014 'Depressive symptoms in chronic hepatitis C are associated with plasma apolipoprotein E deficiency' Metabolic brain disease 29, (3) 625-634 , DOI