Anichtchik, Oleg - Plymouth University

个人简介

2013 - present - Principal Investigator, Lecturer, Department of Clinical Neurobiology, Plymouth University Schools of Medicine and Dentistry. Qualifications Education: 2001 - Ph.D. degree was awarded by the Faculty of Mathematics and Natural Sciences, Åbo Akademi University, Turku, Finland; 1996 - M.D. degree was awarded by the Faculty of the General Medicine, Grodno State Medical Institute, Grodno, Belarus. Previously held positions: 2010 - 2013 - Alzheimer Research UK (ARUK) Senior Research fellow, Centre for Brain Repair, University of Cambridge, United Kingdom ; 2009 - 2012 - Clare College Research Associate, University of Cambridge, United Kingdom ; 2007-2010 - Postdoctoral fellow at Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom; 2005 - 2007 - Senior Research Associate, Daniolabs Ltd, Cambridge, United Kingdom; 2001 - 2004 - Finnish Academy of Sciences postdoctoral fellow, Institute of Biomedicine, Department of Anatomy, University of Helsinki, Finland; 1995 - 1996 - Junior researcher at the Laboratory of Morphology and Neurochemistry, Institute of Biochemistry, Academy of Sciences of Belarus, Grodno, Belarus. Professional membership

研究领域

Understanding mechanisms of insoluble protein aggregates formation and cellular degeneration in the human brain is one of the most pressing questions of clinical neurobiology. We are trying to understand the process of alpha-synuclein aggregation in the development of neurodegenerative disorders such as Parkinson's disease and dementia with Lewy bodies. In particular, we are looking for the reasons of a selective vulnerability of neurons to the toxic insult caused by aggregating proteins and whether dis-aggregating strategies could be beneficial in these conditions. To address this, classical neuromorphology, biochemistry and cell biology techniques are used in the range of in vitro and in vivo models, including human post-mortem studies, animal models of neurodegeneration and cell culture assays.

近期论文

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Hall K, Yang S, Sauchanka O, Spillantini MG & Anichtchik O 2015 'Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein' Exp Neurol 264, 8-13 Author Site , DOI Malek N, Swallow D, Grosset KA, Anichtchik O, Spillantini M & Grosset DG 2014 'Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review' Acta Neurol Scand 130, (2) 59-72 Author Site , DOI Garcia-Reitboeck P, Anichtchik O, Dalley JW, Ninkina N, Tofaris GK, Buchman VL & Spillantini MG 2013 'Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra' Exp Neurol 248, 541-545 Author Site , DOI Anichtchik O, Calo L & Spillantini MG 2013 'Synaptic dysfunction in synucleinopathies' CNS Neurol Disord Drug Targets 12, (8) 1094-1100 Author Site Shelkovnikova TA, Ustyugov AA, Millership S, Peters O, Anichtchik O, Spillantini MG, Buchman VL, Bachurin SO & Ninkina NN 2011 'Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice' Neuro-degenerative diseases 8, (6) 430-437 , DOI Pan-Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, Jackson S, Gille G, Spillantini MG & Reichmann H 2010 'Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice' PLoS One 5, (1) Author Site , DOI Garcia-Reitböck P, Anichtchik O, Bellucci A, Iovino M, Ballini C, Fineberg E, Ghetti B, Della Corte L, Spano P & Tofaris GK 2010 'SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease' Brain 133, (Pt 7) 2032-2044 Author Site , DOI Jin CY, Anichtchik O & Panula P 2009 'Altered histamine H3 receptor radioligand binding in post-mortem brain samples from subjects with psychiatric diseases' Br J Pharmacol 157, (1) 118-129 Author Site , DOI