季莉莉 - 上海中医药大学

个人简介

季莉莉研究员、博士生导师教育背景 1994.09－1999.07 中国药科大学理学学士 1999.09－2004.07 中国药科大学理学博士中科院上海生化细胞研究所工作经历 2004.08－2004.12 中科院上海有机化学研究所助理研究员 2005.01－2005.08 美国普度(Purdue)大学访问学者 2005.12－2008.01 上海中医药大学中药研究所助理研究员 2008.01－2010.12 上海中医药大学中药研究所副研究员 2011.01 - 今上海中医药大学中药研究所研究员个人荣誉国家优秀青年基金获得者，教育部新世纪人才，曙光学者，上海市科技启明星，上海市卫计委优青研究成果获得教育部高等学校科学研究优秀成果一等奖1项；先后承担包括国家自然科学基金优秀青年基金，科技部十二五“重大新药创制”项目等国家和省部级课题10余项；发表科研论文90余篇，其中SCI收录论文60余篇，论文总影响因子达154.6；申请发明专利6项，获授权发明专利2项。

研究领域

药物性（有毒中药）肝损伤及其解毒、中药及其活性成分通过靶向调控血管新生在肿瘤、血管新生性视网膜病、伤口愈合等疾病中的应用及其机理。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Ji LL*, Sheng YC, Zheng ZY, Shi L, Wang ZT*. The involvement of p62-Keap1-Nrf2 antioxidant signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity. Free Radical Biology & Medicine 2015, 85: 12-23. 2. Yu ZY, Lu B, Sheng YC, Zhou LY, Ji LL*, Wang ZT. Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation. Biochimica et Biophysica Acta-General Subject 2015, 1850: 824-831. 3. Ji LL*, Zheng ZY, Shi L, Huang YJ, Lu B, Wang ZT*. Andrographolide decreased VEGFD expression in hepatoma cancer cells by inducing ubiquitin/proteasome-mediated cFos protein degradation. Biochimica et Biophysica Acta-General Subject 2015, 1850: 750-758. 4. Gong CY, Yu ZY, Lu B, Yang L, Sheng YC, Fan YM, Ji LL*, Wang ZT. Ethanol extract of Dendrobium chrysotoxum Lindl ameliorates diabetic retinopathy and its mechanism. Vascular Pharmacology 2014, 62: 134-142. 5. Ji LL*, Ma YB, Wang ZY, Cai ZX, Pang C, Wang ZT. Quercetin prevents pyrrolizidine alkaloid clivorine-induced liver injury in mice by elevating body defense capacity. PLOS one 2014, 9 (6): e98970. 6. Ji LL*, Jiang P, Lu B, Sheng YC, Wang X, Wang ZT*. Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism. The Journal of Nutritional Biochemistry 2013, 24(11):1911-1919. 7. Shen KK, Ji LL*, Gong CY, Ma YB, Yang L, Fan Y, Hou MQ, Wang ZT*. Notoginsenoside Ft1 promotes angiogenesis via HIF-1a mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways. Biochemical Pharmacology 2012, 84(6): 784-792. 8. Liang QN, Sheng YC, Jiang P, Ji LL*, Xia YY, Min Y, Wang ZT*. The difference of glutathione antioxidant system in newly weaned and young mice liver and its involvement in isoline-induced hepatotoxicity. Archives of Toxicology 2011, 85(10):1267-79. 9. Ji LL*, Shen KK, Jiang P, Morahan G, Wang ZT*. Critical Roles of Cellular Glutathione Homeostasis and JNK Activation in Andrographolide-Mediated Apoptotic Cell Death in Human Hepatoma Cells. Molecular Carcinogenesis 2011, 50 (8): 580-591. 10. Liang QN, Sheng YC, Jiang P, Ji LL*, Xia YY, Min Y, Wang ZT*. The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury. Toxicology 2011, 280(1-2): 61-69.