陶厚朝 - 上海中医药大学 - 创新中药研究院

个人简介

招生专业：院系名称专业大类一级学科专业代码/专业名称学位类型招生类型创新中药研究院医学中药学 100800/中药学学术型硕士个人简历： 2021.10-目前研究员，上海市中医药大学创新中药研究院手性药物研究中心 2014.07-2021.09 副研究员，上海科技大学iHuman研究所 2008.10-2014.06 研究助理，Scripps研究所，合作导师：Qinghai Zhang教授 2002.09-2008.06 博士，Scripps研究所，有机化学专业（导师：Dale L. Boger教授） 1999.09-2002.06 硕士，中科院上海有机化学研究所，有机化学专业（导师：俞飚教授） 1995.09-1999.07 学士，南开大学，化学专业主持科研项目：课题名称项目名称起止时间金额用于膜蛋白研究的去垢剂的合成与应用国家自然科学基金 2016.1-2020.12 65万

研究领域

中药活性分子的发现与结构优化糖及缀合物的化学合成

近期论文

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Luo, W., Yang, M., Zhao, Y., Wang, H., Yang, X., Zhang, W., Zhao, F., Zhao, S.*, Tao, H.* Transition-Linker Containing Detergents for Membrane Protein Studies. Chem. Eur. J. 2022, 28, e202202242 Zhao, F., Zhu, Z., Xie, L., Luo, F., Wang, H., Qiu, Y., Luo, W., Zhou, F., Xue, D., Zhang, Z., Hua, T., Wu, D., Liu, Z., Le, Z.*, Tao, H.* Two-Dimensional Detergent Expansion Strategy for Membrane Protein Studies. Chem. Eur. J. 2022, 28, e202201388. Zhao, F., Wu, Y., Zhou, F., Xue, D., Zhao, S., Lu, W., Liu, X., Hu, T., Qiu, Y., Li, R., Gu, T., Xu, Y., Xu, F., Zhong, G., Jiang, Z., Zhao, S.*, Tao, H.* Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement. J Med Chem. 2021, 64, 13830-13840. Hu, T., Zheng, G., Xue, D., Zhao, S., Li, F., Zhou, F., Zhao, F., Xie, L., Tian, C., Hua, T., Zhao, S., Xu, Y., Zhong, G., Liu, Z., Makriyannis, A., Stevens, R.C., Tao, H.* Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools. J Med Chem. 2021, 64, 13752-13765. Zhou, F., Ding, K., Zhou, Y., Liu, Y., Liu, X., Zhao, F., Wu, Y., Zhang, X., Tan, Q., Xu, F., Tan, W., Xiao, Y.*, Zhao, S.* and Tao, H.*, Colocalization strategy unveils an underside binding site in the transmembrane domain of smoothened receptor. J. Med. Chem. 2019, 62, 9983-9989. Xue, D., Xu, T., Wang, H., Wu, M., Yuan, Y., Wang, W., Tan, Q., Zhao, F., Zhou, F., Hu, T., Jiang, Z., Liu, Z.-J., Zhao, S., Liu, D., Wüthrich, K.* and Tao, H.*, Disulfide-containing detergents (DCDs) for the structural biology of membrane proteins. Chem. Eur. J. 2019, 25, 11635-11640. Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P. R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.S., Cherezov, V., Stevens, R.C., Tan, W.*, Tao, H.*, and Xu, F.*, Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat. Commun. 2017, 8, 15383. Tao, H.†, Lee, S.C.†, Moeller, A.†, Roy, R.S., Siu, F.Y., Zimmermann, J., Stevens, R.C., Potter, C.S., Carragher, B., Zhang, Q.*, Engineered nanostructured β-sheet peptides protect integral membrane proteins as stable and functional single particles. Nature Methods, 2013, 10, 759-761.