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个人简介

先后在TrAC Trends in Analytical Chemistry, Biosensors & Bioelectronics, Acta Pharmaceutica Sinica B, ACS Sensors, Materials Science & Engineering C, Organic. Letters, European Journal of Medicinal Chemistry等国际知名期刊发表SCI论文60余篇,H因子23,引用>1600次。其中1篇为ESI热点论文,3篇为ESI高被引论文,1篇获2019 Acta Pharm Sin B. Outstanding Paper Award。已授权发明专利8项(含国际专利2项)。先后主持或参与国家自然科学基金、“重大新药创制”国家重大专项、“中医药现代化研究”重点专项、上海市自然科学基金面上项目和“三年行动计划”等项目10项;作为项目负责人主持企业委托横向课题4项。主参与编写《系统药代动力学》一部,英文专著《Pharmaceutical Biocatalysis》一部参。获“辽宁省自然科学学术成果”一等奖1项(排名第一),世界中医药学会联合会“中医药国际贡献奖—科技进步”二等奖1项(排名第三)入选上海中医药大学“杏林学者”、国家中医药管理局“中医药国际化骨干人才培养”项目。 招生专业 院系名称 专业大类一级学科 专业代码/专业名称 学位类型招生类型 交叉科学研究院 医学 中药学100800/中药学 学术学位 硕士 交叉科学研究院 医学中药学 105600/中药学 专业学位 硕士 教育及任职经历 2018.01-至今,上海中医药大学,交叉科学研究院,副研究员 2022.12-至今,上海交通大学, 化学化工学院(周永丰团队),访问学者 2019.12-2020.11,上海浦东科技和经济委员会,生物医药和新材料处,挂职 2017.03-2017.12,上海中医药大学,交叉科学研究院,助理研究员 2014.07-2017.02,中国科学院大连化学物理研究所,生物技术部,博士后 2010.09-2014.06,大连理工大学,制药科学与技术学院,有机化学,博士 2008.07-2010.07,大连富乐马生物科技有限公司(Italy Flamma R&D Center),药物研发工程师 2005.09-2008.06,辽宁师范大学,化学化工学院,有机化学,硕士 2001.09-2005.07,辽宁师范大学,化学化工学院,应用化学,学士 近五年以第一负责人承担的科研课题与经费 序号课题类型课题名称项目时间项目经费(万元)备注 1国家重大专项“重大新药创制”子课题 中药组份配伍成药性评价关键技术2018.01-2020.12 113.04 主持 2 国家科技部重点研发计划“中医药现代化研究” 基于器官芯片技术的中药安全性有效性评价体系 2018.01-2021.12 99/1898 任务负责人 3 国家自然科学青年基金DPP-IV特异性荧光探针研发及应用基础研究2017.01-2019.1220主持 4上海中医药大学第五批“杏林中青年人才”项目人源丝氨酸水解酶酶活性评价新方法开发及其在中药活性成分发现中的应用2021.01-2023.12 15 主持 5 上海市自然科学基金面上项目 特异性PREP近红外荧光检测方法的构建及其在神经药理学中的应用 2023.04-2026.03 20 主持

研究领域

致力于人源丝氨酸水解酶检测新方法开发与应用、中药活性成分发现与成药性优化、中药-药物相互作用。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Qiang Jin#, Li-Lin Song#, Le-Le Ding, Jing Zhang, Dan-Dan Wang, Yun-Qing Song, Li-Wei Zou*, Guang-Bo Ge*, High-throughput optical assays for sensing serine hydrolases in living systems and their applications, TrAC Trends in Analytical Chemistry, 2022, 152, 116620. (IF = 14.908) 2. Jing Zhang#, Qiu-Sha Pan#, Xing-Kai Qian, Xiang-Lu Zhou, Ya-Jie Wang, Rong-Jing He, Le-Tian Wang, Yan-Ran Li, Hong Huo, Cheng-Gong Sun, Lei Sun**, Li-Wei Zou*, Ling Yang, Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 371, 629-640. (IF = 5.756) 3. Pei-Fang Song#, Qui-Sha Pan#, Zhao-Hui Sun, Li-Wei Zou*, Ling Yang*, Fibroblast activation protein alpha: Comprehensive detection methods for drug target and tumor marker, Chemico-Biological Interactions, 2022, 354, 109830. (IF = 5.168) 4. Xing-Kai Qian#, Jing Zhang#, Xiao-Dong Li, Pei-Fang Song, Li-Wei Zou*, Research Progress on Dipeptidyl Peptidase Family: Structure, Function and Xenobiotic Metabolism. Current Medicinal Chemistry, 2022, 29, 2167-2188. (IF = 4.74) 5. Dan-Dan Wang#, Xing-Kai Qian#, Hong-Xin Li, Gui-Hua Jia, Qiang Jin, Xin Luan, Ya-Di Zhu, Yi-Nan Wang, Jian Huang, Li-Wei Zou*, Guang-Bo Ge*, Ling Yang*, Sensing and imaging of exosomal CD26 secreted from cancer cells and 3D colorectal tumor model using a novel near-infrared fluorogenic probe, Materials Science & Engineering C, 2021, 130, 112472. (IF = 8.457) 6. Yun-Qing Song#, Qiang Jin#, Dan-Dan Wang, Li-Wei Zou*, Guang-Bo Ge*, Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism. Chemico-Biological Interactions, 2021, 345, 109566. (IF = 5.168) 7. Jing Zhang, Xing-Kai Qian, Pei-Fang Song, Xiao-Dong Li, An-Qi Wang, Hong Huo, Jing-Chun Yao, Gui-Min Zhang* and Li-Wei Zou*, A high-throughput screening assay for dipeptidyl peptidase-IV inhibitors using human plasma, Analytical Methods, 2021, 13, 2671-2678. (IF = 3.532) 8. Xing-Kai Qian#, Jing Zhang#, Pei-Fang Song, Yi-Su Zhao, Hong-Ying Ma, Qiang Jin, Dan-Dan Wang, Xiao-Qing Guan, Shi-Yang Li, Xiao-Ze Bao*, Li-Wei Zou*, Discovery of Pyrazolones as Novel Carboxylesterase 2 Inhibitors that Potently Inhibit the Adipogenesis in Cells, Bioorganic & Medicinal Chemistry, 2021, 40, 116187. (IF = 3.461) 9. Jing Zhang#, Yang Yang#, Xing-Kai Qian, Pei-Fang Song, Yi-Shu Zhao, Xiao-Qing Guan*, Li-Wei Zou*, Xiaoze Bao*, and Hong Wang. Design Synthesis and Structure Activity Relationship Study of Pyrazolones as Potent Inhibitors against Pancreatic Lipase, ChemMedChem, 2021, 16(10), 1600-1604. (IF = 3.54) 10. Dan-Dan Wang#, Li-Wei Zou#, Qiang Jin, Xiao-Qing Guan, Yang Yu, Ya-Di Zhu, Jian Huang, Peng Gao, Ping Wang, Guang-Bo Ge*, Ling Yang*, A bioluminescent sensor reveals that carboxylesterase 1A is a novel endoplasmic reticulum-derived serologic indicator for hepatocyte injury, ACS Sensors, 2020, 5, 1987-1995. (IF = 9.618) 11. Yi-Shu Zhao#, Xing-Kai Qian#, Xiao-Qing Guan, Pei-Fang Song, Yun-Qing Song, Rong-Jing He, Meng-Ru Sun, Xiu-Yang Wang, Li-Wei Zou*, Guang-Bo Ge*. Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2, Bioorganic Chemistry, 2020, 105, 104367. (IF = 5.307) 12. Hong Ma#, Xing-Kai Qian#, Jing Zhang, Qiang Jin, Li-Wei Zou*, Shu-Qing Liu*, and Guang-Bo Ge, Accurate and sensitive detection of dipeptidyl peptidase-IV activity by liquid chromatography with fluorescence detection, Anal. Methods, 2020, 12, 848-854. (IF = 3.532) 13. Yi-Shu Zhao#, Hong-Li Ruan#, Xiu-Yang Wang, Chen Chen, Pei-Fang Song, Cheng-Wei Lü*, Li-Wei Zou*, Catalyst-free visible-light-induced condensation to synthesize is (indolyl) methanes and biological activity evaluation of them as potent human carboxylesterase 2 inhibitors, RSC Advances, 2019, 9, 40168-40175. (IF = 4.036) 14. Pei-Fang Song#, Ya-Di Zhu#, Hong-Ying Ma, Yi-Nan Wang, Dan-Dan Wang*, Li-Wei Zou*, Guang-Bo Ge, Ling Yang, Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1. Fitoterapia, 2019, 137, 104199. (IF = 3.204) 15. Dan-Dan Wang#, Li-Wei Zou#, Qiang Jin, Jie Hou, Guang-Bo Ge*, Ling Yang, Human carboxylesterases: a comprehensive review, Acta Pharmaceutica Sinica B, 2018, 8, 699-712. (IF = 14.903, ESI高被引论文) 16. Xiao-Ze Bao, Shi-Qiang Wei, Xing-Kai Qian, Jing-Ping Qu, Bao-Min Wang*, Li-Wei Zou*, Guang-Bo Ge, Asymmetric Construction of a Multi- pharmacophore- containing dispirotriheterocyclic scaffold and identification of a human carboxylesterase 1 inhibitor, Organic Letters, 2018, 20, 3394-3398. (IF = 6.072) 17. Li-Wei Zou#, Qiang Jin#, Dan-Dan Wang, Da-Cheng Hao, Guang-Bo Ge*, Ling Yang, Carboxylesterase inhibitors: an update, Current Medicinal Chemistry, 2018, 25, 1627-1649. (IF = 4.74, ESI高被引论文) 18. Li-Wei Zou#, Ping Wang#, Xing-Kai Qian, Lei Feng, Yang Yu, Dan-Dan Wang, Qiang Jin, Jie Hou, Zhi-Hong Liu, Guang-Bo Ge*, Ling Yang*, A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems, Biosensors & Bioelectronics, 2017, 90, 283-289. (IF = 12.545) 19. Li-Wei Zou#, Tong-Yi Dou #, Ping Wang, Wei Lei, Zi-Miao Weng, Jie Hou, Dan-Dan Wang, Yi-Ming Fan, Wei-Dong Zhang, Guang-Bo Ge*, Ling Yang, Structure-activity relationships of pentacyclictriterpenoids as potent and selective inhibitors against human carboxylesterase 1, Frontiers in Pharmacology, 2017, 08, 435. (IF = 5.988) 20. Li-Wei Zou, Yao-Guang Li, Ping Wang, Kun Zhou, Jie Hou, Qiang Jin, Da-Cheng Hao, Guang-Bo Ge*, Ling Yang, Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2, European Journal Of Medicinal Chemistry, 2016, 112, 280-288. (IF = 7.088)

学术兼职

。Acta Pharmacologica Sinica, Bioorganic Chemistry, RSC Advances, Evidence-based Complementary and Alternative Medicine等学术刊物审稿人。中国中药协会中药产品开发与培育专业委员会委员,中华中医药学会中药实验药理分会青年委员、药物代谢专业委员会第二届青年委员会委员,上海药理学会药物代谢专业委员会委员。

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