Faulkner, Christine - Oxford Brookes University - Department of Biological and Medical Sciences

研究领域

I work on how plant cells communicate with each other when under attack by fungal and bacterial pathogens. I am interested in how a threatened cell sends out warnings to neighbouring cells and what role this has in how plants defend themselves. I completed my PhD at the University of Sydney (Australia) and have since worked as a postdoctoral scientist at the University of Edinburgh, the John Innes Centre and the Sainsbury Laboratory. When a plant cell is attacked by a pathogen a variety of defence responses are triggered in that cell that prevent further invasion of the pathogen. All plant cells are connected to each other via channels called plasmodesmata. These channels close to isolate the attacked cell early during pathogen attack, presumably to prevent the spread of toxic molecules involved in defence responses. I am working to understand how plasmodesmata close and open during pathogen attack and how an attacked cell sends signals to its neighbours to warn them of imminent invasion.

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Faulkner, C., Petutschnig, E., Benitez-Alfonso, Y., Beck, M., Robatzek, S., Lipka, V., Maule, AJ. (2013) LYM2-dependent chitin perception limits molecular flux via plasmodesmata. Proceedings of the National Academy of Sciences;110(22) DOI:10.1073/pnas.1203458110 Fitzgibbon, J., Beck, M., Zhou, J., Faulkner, C., Robatzek, S., Oparka, K. (2013) A developmental framework for complex plasmodesmata formation revealed by large-scale imaging of the Arabidopsis leaf epidermis. The Plant Cell 25(1):57-70. DOI:10.1105/tpc.112.105890. Zhou, J., Spallek, T., Faulkner, C., Robatzek, S. (2012) CalloseMeasurer: a novel software solution to measure callose deposition and recognise spreading callose patterns. Plant Methods 8(1):49. DOI:10.1186/1746-4811-8-49 Bricchi, I., Occhipinti, A., Bertea, CM., Zebelo, SA., Brillada, C., Verrillo, F., De Castro, C., Molinaro, A., Faulkner, C., Maule, AJ., Maffei, ME. (2012) Separation of early and late responses to herbivory in Arabidopsis by changing plasmodesmal function. Plant Journal DOI:10.1111/j.1365-313X.2012.05103.x Beck, M., Zhou, J., Faulkner, C., MacLean, D., Robatzek, S. (2012) Spatio-temporal cellular dynamics of the Arabidopsis flagellin receptor reveal activation status-dependent endosomal sorting. The Plant Cell 24(10):4205-19. DOI:10.1105/tpc.112.100263. Faulkner, C., Robatzek, S. (2012) Plants and pathogens: putting infection strategies and defence mechanisms on the map. Current Opinion in Plant Biology 15(6):699-707. DOI:10.1016/j.pbi.2012.08.009. Fernandez-Calvino, L., Faulkner, C., Walshaw, J., Saalbach, G., Bayer, E., Benitez-Alfonso, Y., Maule, A. (2011) Arabidopsis plasmodesmal proteome. PLoS One 6(4):e18880. doi: 10.1371/journal.pone.0018880.