Evans, David - Oxford Brookes University - Department of Biological and Medical Sciences

个人简介

I am a one of the plant cell biologist at Oxford Brookes University with research and teaching interests in plant biotechnology and food security. I came to Oxford Brookes in 1992 after research fellowships in the Department of Plant Sciences, the University of Oxford, initially as a Royal Society University Research Fellow. I have researched both cellular and environmental topics, including ion transport and membrane biology; the mechanism by which silicon ameliorates aluminium toxicity; programmed cell death and most recently (since 2000) the proteins of the plant nuclear envelope. My research involves me in collaborations in the UK, Europe and the USA and together we are making significant advances in understanding how the nuclear envelope connects with other structures of the cell, contributes to the structure of chromatin and affects gene expression. Much of the work is funded by the Leverhulme Trust; recently we have been working on a ‘proof of concept’ project with our French collaborators to commercialise some of our findings. I have written and edited several text books and advanced texts and publish regularly as well as organising conferences on the nuclear envelope for the Society for Experimental Biology and the Biochemical Society. I was for a number of years Cell Biology Secretary of the Society for Experimental Biology. My teaching interests in plant biotechnology and plant science include both fundamental plant science and crop production.

研究领域

I have extensive interests in doctoral education and until recently was Head of the University Graduate School, as well as being postgraduate research tutor for the Faculty of Health and Life Sciences. I was a member of the Quality Assurance Agency panel who revised the Code of Practice for student assessment and am Chief External Examiner (Postgraduate Programmes) for Bath Spa University. I am active in the area of Public Understanding of Science as a member of the Society for Experimental Biology Science and Public Affairs Committee. My current research concerns the proteins of the plant nuclear envelope and their interactions with Chromatin and with the cytoskeleton. Following the discovery and characterisation of the first members of the the Sad1/UNC-84 (SUN) domain protein family in various plant species we are currently working with the Arabidopsis homologues AtSUN1 and AtSUN2. The SUN domain proteins are INM localised proteins, which, in animal and yeast cells, form part of a complex that bridges both membranes of the NE to connect cytoskeletal elements to the nucleoskeleton and chromatin. These nucleo-cytoskeletal bridging complexes allow transmission of cellular signals to the nucleus and are essential in various cell functions such as movement and positioning of the nucleus, anchorage of centrosomes/spindle pole bodies, condensation of chromatin and anchorage of telomeres. The work has led to a number of collaborations and has significance to crop protection and food security as the nuclear envelope is very important in plant responses to stress and disease.

近期论文

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Varas, J, Graumann, K, Osman, K, Pradillo, M, Evans, D, Santos, J L, Armstrong, SJ, Absence of SUN1 and SUN2 proteins in Arabidopsis thaliana leads to a delay in meiotic progression and defects in synapsis and recombination. Plant Journal 81, 329 – 346 (2015) Graumann, K, Vanrobays, E, Tutois, S, Probst, A V, Evans, DE, Tatout, C. Characterization of two distinct subfamilies of SUN-domain proteins in Arabidopsis and their interactions with the novel KASH-domain protein AtTIK. Journal of Experimental Botany 65, 6499-6528 (2014) Graumann K, Evans DE., Nuclear envelope dynamics during plant cell division suggest common mechanisms between kingdoms Biochem. J. (2011) 435, 661–667 Prabagar, S., Hodson, M. J. & Evans, D. E. 2011. Silicon amelioration of aluminium toxicity and cell death in suspension cultures of Norway spruce (Picea abies (L.) Karst.). Environmental and Experimental Botany, 70, 266-276. Graumann, K., Runions, J. & Evans, D. E. 2010. Characterization of SUN-domain proteins at the higher plant nuclear envelope. Plant Journal, 61, 134-144. Evans, D. and Graumann, K. Probing the plant nuclear envelope. 2008. Comparative Biochemistry And Physiology A-Molecular & Integrative Physiology. 150(3): S199-S200. Runions, J., Shvedunova, M., Graumann, K. and Evans, D. 2008. Dynamic interrelationships of secretory pathway endomembranes during cell division. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 150(3): S201-S201. Graumann, K., Irons, S., Runions, J, and Evans, D. 2008. SUN domain proteins at the plant nuclear envelope. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 150(3): S202. Graumann, K., Irons, S., Runions, J. and Evans, D. 2008. Studies on the nuclear envelope targeting and retention of the N-terminus of the mammalian lamin B receptor expressed in plant cells. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 150(3): S202. Graumann, K., Irons, S.L., Runions, J. and Evans, D.E. 2007. Retention and mobility of the mammalian lamin B receptor in the plant nuclear envelope. Biology of the Cell. 99: 553-562.