个人简介

Dr Ugun- Klusek is a Research Fellow in Cell Biology. She also acts as a representative for Research Fellows and Associates in the School of Science and Technology.

研究领域

Klusek – neurodegeneration, proteomics, PD and AD models, monoamine oxidase

Dr Ugun- Klusek is a member of Professor Ellen Billet's research team. Her research interests are involvement of enzyme monoamine oxidase in cell death / survival mechanisms and neurodegeneration. In addition she is interested in the application of proteomics techniques to study disease mechanisms

近期论文

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Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins. Fitzgerald JC, Ugun-Klusek A, Allen G, De Girolamo LA, Hargreaves I, Ufer C, Abramov AY and Billett EE, The FASEB Journal, 2013, doi:10.1096/fj.13-235481 (e-pub ahead of print) Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones. Elkharaz J, Ugun-Klusek A, Constantin-Teodosiu T, Lawler K, Mayer RJ, Billett E, Lowe J, Bedford L, Biochim Biophys Acta. 2013, 1832 (12), 1930-1938 Reduced placental vascular reactivity to 5-hydroxytryptamine in pre-eclampsia and the status of 5HT2A receptors. Ugun-Klusek A, Tamang A, Loughna P, Billett E, Buckley G and Sivasubramaniam S, Vascular Pharmacology, 2011, 55 (5-6), 157-162 Monoamine oxidase a expression is vital for embryonic brain development by modulating developmental apoptosis.Wang CC, Borchert A, Ugun-Klusek A, Tang LY, Lui WT, Chu CY, Billett E, Kuhn H and Ufer C, The Journal of Biological Chemistry, 2011, 286 (32), 28322–28330