个人简介

Professor Billett is the Research Coordinator for the School of Science and Technology, Chair of the School of Science and Technology Research Committee and is Director of Interdisciplinary Biomedical Research, co-ordinating the REF Unit of Assessment A03: Allied Health Professions and Studies. Professor Billett is Module leader of Cell culture and antibody technology (M level, both FT and flexi-learning modes), and teaches on M level modules Neurobiology and neuropathology and Research project.

研究领域

monoamine oxidase (MAO), mitochondrial dysfunction, neurodegeneration

Areas of research interest include monoamine oxidase (MAO), development of cell culture systems to study neurodegeneration and food authenticity. The role of monoamine oxidase (MAO) in health and disease: Monoamine oxidase plays an important role in the metabolism of exogenous amines and the control of neurotransmitter levels and intracellular amine stores. Perturbation of MAO has been implicated in a number of psychiatric and somatic diseases. Professor Billett's group is particularly interested in its potential roles in pregnancy-induced hypertension, in peripheral tissues, in programmed cell death and in development. MAO-A and MAO-B monoclonal antibodies generated in their laboratory are used in this work, together with recombinant DNA approaches. The development of cell culture systems to study neurodegeneration: Cells are exposed to neurotoxins such as MPTP and rotenone, used as Parkinson Disease mimetics since they inhibit complex 1 of the electron transport chain. Current work is focussing on how the mitochondrial proteome is affected by complex 1 inhibitors. Food Authenticity: Professor Billett's laboratory has extensive experience in the application of proteomics in biomedical sciences (see above) and in food sciences. Her group has developed novel proteomic methods to detect undeclared offal and added serum in meat products.

近期论文

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Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins. Fitzgerald JC, Ugun-Klusek A, Allen G, De Girolamo LA, Hargreaves I, Ufer C, Abramov AY, Billett EE, FASEB J, 2014, 28 (1), 218-229 Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones. Elkharaza J, Ugun-Klusek A, Constantin-Teodosiua D, Lawlera K, Mayera RJ, Billett EE, Lowe J, Bedford L, Biochimica et Biophysica Acta- Moelcular Basis of Disease, 2013, 1832 (12), 1930 Monoamine oxidase a expression is vital for embryonic brain development by modulating developmental apoptosis. Wang CC, Borchert A, Ugun-Klusek A, Tang LY, Lui WT, Chu CY, Billett EE, Kuhn H , Ufer C, Journal of Biological Chemistry, 2011, 286 (32) 28322-28330 Alterations in the mitochondrial proteome of neuroblastoma cells in response to complex 1 inhibition. Billett EE, Burte F, De Girolamo LA, Hargreaves AJ, J.Proteome Research, 2011, 10 (4), 1974-1986 An investigation of the potential anti-immunosenescent effects of MitoQ. Barnett YA, Billett EE, Marthandan S, Murphy M. Free Radical Research, 2011, 45 (3), 351–358 Alzheimer’s disease modifies progenitor cell expression of monoamine oxidase B in the subventricular zone. Pugliese M, Rodríguez MJ, Gimeno-Bayon J, Pujadas L, Billett EE, Wells C, Mahy N, Journal of Neuroscience Research, 2010, 88 (12) 2588-2597 Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development. Ufer C, Wang CC, Fähling M, Schiebel H, Thiele BJ, Billett EE, Kuhn H, Borchert A, Genes and Development, 2008, 22, 1838-1850