Sadofsky, Laura - University of Hull - Department of Biology / Biomedical Sciences

个人简介

Lecturer, University of Hull 2011-present Post-doctoral research associate cardiovascular and respiratory studies, University of Hull 2006-2011 PhD Medicine-respiratory medicine, University of Hull 2006 MSc Toxicology, University of Birmingham 2001 BSc Biochemistry, University of Birmingham 2000

研究领域

TRP Channels I am interested in the Transient Receptor Potential (TRP) cation channels TRPA1, TRPV1, TRPV3 and TRPM8 (TRP ankyrin-1, vanilloid-1, vanilloid-3 and melastatin-8) and their roles in respiratory diseases. These ion channels detect noxious stimuli both chemical and physical and are involved in inflammation, pain and cough. PAR Receptors Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors activated by proteolytic cleavage of their receptor N-terminus primarily by serine proteinases. The cleavage of the N-terminus results in the exposure of what is termed a "tethered ligand" which subsequently binds to and activates the receptor. We are interested in the molecular pharmacology of the PARs and their role in disease as well as the role that post-translational modifications exert on this receptor family.

近期论文

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Sadofsky LR, Ramachandran R, Crow C, Cowan M, Compton S.J. and Morice AH. (2012) Inflammatory stimuli upregulate TRPV1 expression in human bronchial fibroblasts. Experimental Lung Research. 38, 75-81. Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andre E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, and Geppetti, P. (2011) The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain : a journal of neurology Botham A, Guo X, Xiao Y, Morice AH. Compton, S. J and Sadofsky, LR. (2011) Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal. 438, 359-367. Xiao Y, Morice AH, Compton SJ and Sadofsky LR. (2011) N-Linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin. Journal of Biological Chemistry. 286, 22991-23002. Sadofsky LR, Boa AN, Maher SA, Birrell MA, Belvisi MG and Morice AH. (2011) TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacology Research 63, 30-36. Nassini R, Materizzi S, Andrè E, Sartiani L, Aldini G, Trevisani M, Carnini C, Massi, D, Pedretti P, Carini M, Cerbai E, Preti D, Villetti G, Civelli M, Trevisan G, Azzari C, Stokesberry S, Sadofsky L, McGarvey L, Paracchini R and Geppetti P. (2010) Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J 24, 4904-4916 Birrell MA, Belvisi MG, Grace M, Sadofsky L, Faruqi S, Hele DJ, Maher SA, Freund-Michel V and Morice AH. (2009) TRPA1 agonists evoke coughing in guinea pig and human volunteers. American Journal of Respiratory and Critical Care Medicine. 180, 1042-1047.