Rotchell, Jeanette - University of Hull - Department of Biology / Biomedical Sciences

个人简介

From October 2010 - Professor of Environmental Science, University of Hull Senior Lecturer, University of Sussex PhD (Glasgow Caledonian) MSc (Heriot-Watt) BSc (Napier)

研究领域

These focus on the biological effects of various classes of environmental contaminants at the molecular level - molecular ecotoxicology. Specifically, detoxification mechanisms and their use as biomarkers of environmental contamination (for example, cytochrome P450IA1 enzyme activity and metallothionein concentrations). Second, is the induction of DNA damage in critical growth regulating genes, such as the ras oncogene and retinoblastoma (Rb) tumour suppressor gene, plus their role in development of a 'mutator phenotype' and genome instability. Funded research projects include: Chemically-induced genetic damage in fish and invertebrates (ras, Rb, p53 genes). Biomarker development for hydrocarbon and heavy metal contaminant exposure. Development of molecular biomarkers of endocrine disruption in the invertebrate, Mytilus edulis L. Characterisation of UV- and chemically-induced DNA damage response genes in bleaching susceptible and bleaching-resistant coral.

近期论文

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Cubero-Leon, E., Ciocan, C.M., Hill, E.M., Osada, M., Kishida, M., Itoh, N., Kondo, R., Minier, C., Rotchell, J.M. 2010. Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis). Aquat. Toxicol. 98:178-187. Ciocan C.M., Cubero-Leon, E., Puinean, A.M., Hill, E.M., Minier, C., Osada, M., Fenlon, K., Rotchell, J.M. In press. Effects Of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis. Environ. Pollut. Nogueira, P.R., Pacheco, M., Pereira, M.L., Mendo, S., Rotchell, J.M. 2010. Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination. Environ. Pollut. 158:1783-1790. Rotchell, J.M., du Corbier, F.A., Stentiford, G.D., Lyons, B.P., Liddle, A.R., Ostrander, G.K. 2009. A comparison of retinoblastoma gene mutation profiles between humans and the marine flatfish Dab (Limanda limanda). Comp. Biochem. Physiol. C 149:134-140.