Pires, Isabel - University of Hull - Department of Biology / Biomedical Sciences

个人简介

Since 2012 Lecturer in Biomedical Science and Principal Investigator (Hypoxia and Tumour Microenvironment group), SoBBES, University of Hull, UK 2007 - 2012 Postdoctoral Researcher, CRUK Institute for Radiation Oncology, Department of Oncology, University of Oxford, UK 2003 - 2007 Ph.D. Pharmacology, The University of Manchester/CRUK Manchester Institut 2001 - 2002 Visiting Scientist, University of Manchester 1997 - 2002 Licenciatura (Biology), Universidade de Coimbra, Portugal

研究领域

The tumour microenvironment is a key driver of tumourigenesis and metastatic disease. In particular, regions of low oxygen, or hypoxia, which occur in all solid tumours, are associated with increased malignancy, resistance to therapy and increased metastatic potential. My research interests are focused on identifying and characterising signalling pathways associated to the hypoxic tumour microenvironment and their exploitation for therapeutic benefit. Active research strands in the lab include: 1) Identification of novel regulators of hypoxia-regulated cellular motility and invasion in both HIF dependent and independent mechanisms (funded by the Breast Cancer Campaign and Royal Society; 2) Characterisation of the role of proteases and sheddases in hypoxic tumourigenesis; 3) Development of 3D models of hypoxia-mediated migration and invasion

近期论文

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Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, van der Weyden L, Esashi F, Hammond EM, O'Neill E. (2014) RASSF1A-LATS1 signalling stabilizes stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2. Nature Cell Biology. 16 (10), 962-971 Pires IM*, Blokland NJ, Broos AW, Poujade FA, Senra JM, Eccles SA, Span PN, Harvey AJ,* Hammond EM. (2014)Hypoxia-induced rapid PTK6 stabilisation is associated with increased motility and invasion. Cancer Biology and Therapy. 15(10):1350-7* Co-corresponding author Scrace S, O’Neill E, Hammond, E.M. and Pires, IM. (2013) Use of the xCELLigence system for real time analysis of changes in cellular motility and adhesion in physiological conditions. Adhesion Protein Protocols, Methods in Molecular Biology.1046: 295-306 Olcina MM, Foskolou IP, Anbalagan,S, Senra JM, Pires IM, Jiang J, Ryan AJ, Hammond EM. (2013) Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication. Molecular Cell. 52(5):758-66. Cazares-Korner C**, Pires IM**, Swallow ID**, Grayer SC, O'Connor LJ, Olcina MM, Christlieb M, Conway SJ, Hammond, EM. (2013) CH-01 is a Hypoxia-Activated Prodrug That Sensitizes Cells to Hypoxia/Reoxygenation Through Inhibition of Chk1 and Aurora A. ACS Chemical Biology. 8(7):1451-9 ** equal contribution Pires IM, Olcina M, Anbalagan S, Pollard JR, Reaper PM, Charlton PA, McKenna WG, Hammond EM. (2012) Targeting radiation resistant hypoxic tumour cells through ATR inhibition. Br J Cancer. 107(2):291-9 Anbalagan S, Pires IM, Blick C, Hill MA, Ferguson DJ, Chan DA, Hammond EM. (2012) Radiosensitization of Renal Cell Carcinoma in vitro through the induction of autophagy, Radiotherapy and Oncology. 103(3):388-93 Coutts AS, Pires IM, Weston L, Buffa FM, Milani M, Li JL, Harris AL, Hammond EM, La Thangue NB. (2011) Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α. Oncogene. 30: 4835-4842 Chan N, Pires IM, Bencokova Z, Coackley C, Luoto KR, Bhogal N, Lakshman M, Gottipati P, Oliver FJ, Helleday T, Hammond EM, and Bristow RG. (2010) Contextual synthetic lethality of cancer cell kill based on the tumour microenvironment. Cancer Res. 15;70(20):8045-54 Pires IM, Bencokova Z, McGurk C and Hammond EM. (2010) Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. Cell Cycle 14;9(13) Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, Harris AL. (2010) Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene. 29(31):4424-35 Pires IM, Bencokova Z, Milani M, Folkes LK, Li JL, Stratford MR, Harris AL, Hammond EM. (2009) Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Res. 70(3):925-35 Pires IM, Ward TH, Dive C. (2010) Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors. Br J Pharmacol. 159(6):1326-38. Jossé L, Harley ME, Pires IM, Hughes DA. (2006) Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Biochem J. 393(Pt 1):303-9. Pires, IM, Poole R and Hammond EM. (2011) Chapter 10: Hypoxia and the DNA Damage Response. In: Tumour Microenvironment. Ed Seimann DW. Wiley-Blackwell Hammond EM, Pires IM, Giaccia AJ. Chapter 2: DNA Damage and Repair. In: Textbook of Radiation Oncology. Eds. Hoppe TR, Phillips TL and Roach M. Elseveir (2010)