Nikitenko, Leonid - University of Hull - Department of Biology / Biomedical Sciences

个人简介

Lecturer in Biomedical Sciences (2015-present), School of Life Sciences, University of Hull, U.K. ● Senior Postdoctoral Scientist (2013-2015; MRC funded), Nuffield Department of Medicine, Ludwig Institute for Cancer Research, University of Oxford, U.K. ● Senior Research Fellow (2006-2013; Cancer Research U.K. funded), Department of Oncology, Wolfson Institute of Biomedical Research and Cancer Institute, University College London, London, U.K. ● Research Fellow RSII (2002-2005; The Wellcome Trust funded), Nuffield Department of Obstetrics and Gynaecology, University of Oxford, U.K. ● Research Fellow RAI (1999-2002; Johnson and Johnson Focused Giving Program funded), Nuffield Department of Obstetrics and Gynaecology and Weatherall Institute of Molecular Medicine, University of Oxford, U.K. ● Lecturer and Tutor in Molecular and Cellular Biomedicine and Medicine (2002-2014), Keble College, Oxford, U.K. ● Doctor of Sciences (2007; Biological Sciences; Pathophysiology), Russian Academy of Medical Sciences, Russian Federation. ● MA Linacre College (2002), Oxford, U.K. ● PhD (1997) (Biological Sciences; Cell and Developmental Biology), Russian Academy of Medical Sciences, Russian Federation. ● MSc (equivalent to Distinction; Human Physiology), University of Irkutsk, Russian Federation. ● BSc (equivalent to First Class Hons; Biological Sciences), University of Irkutsk, Russian Federation.

研究领域

The aim of my previous and current research is to understand the mechanisms which regulate gene expression and function in endothelial and mesenchymal (including stem) cells in normal and pathological conditions. Currently the focus of my laboratory is on genetic, molecular and cellular processes which play a role in tumour angiogenesis, virus-induced oncogenesis, origin and progression of sarcoma, and cancer-related lymphedema; with the prospective long-term goal to contribute to the development of novel therapies for these pathologies. In our studies, we apply interdisciplinary approach to investigate study molecular mechanisms regulating mammalian cell biology in health and pathology (using models of human disease) in clinical investigations/studies in human and murine primary tissues and cells and in animal studies. Our research is based on long-term collaborations within the United Kingdom and globally (Japan, Sweden, Australia and Italy) which yielded several discoveries and patents in the fields of cancer and vascular biology. Key Interests Cancer biology, vascular biology, endothelial cell biology in health and disease, tumour angiogenesis, G-protein coupled receptors, mesenchymal stem cells, genomics, lymphangiogenesis, transcription factors.

近期论文

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Nikitenko LL, Leek R, Henderson S, Turley H, Generali D, Gunningham S, Morrin H, Pellagatti A, Pillay N, Rees MCP, Harris AL, Fox SB. (2013) The G-protein coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis. Clinical Cancer Research,19(20), 5740-8. Nikitenko LL, Shimosawa T, Henderson S, Makinen T, Shimosawa H, Qureshi U, Pedley RB, Rees MCP, Fujita T, Boshoff C. (2013)Adrenomedullin haploinsufficiency predisposes to secondary lymphedema. Journal of Investigative Dermatology, 133(7), 1768-76. Hansen A, Henderson S, Lagos D, Nikitenko LL, Coulter E, Roberts S, Gratrix F, Plaisance K, Renne R, Bower M, Kellam P, Boshoff C. (2010) KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming. Genes Development, 24(2), 195-205. Akoulitchev A, Ramadass A, Nikitenko LL. (2011) DNA conformation (loop structures) in normal and abnormal gene expression. EP 1991697, http://www.google.com/patents/EP1991697 Nikitenko LL. Vascular endothelium in cancer. (2009) Cell Tissue Res, 335(1), 223-40. Vart R, Nikitenko LL, Lagos D, Trotter M, Gratrix F, Bourboulia D, Takeuchi Y, Boshoff C. (2007) Kaposi’s Sarcoma-associated Herpesvirus encoded vIL6 and vGPCR regulate angiopoietin-2 expression in lymphatic endothelial cells Cancer Research, 67(9), 4042-51. Nikitenko LL, Blucher N, Fox S, Smith DM, Bicknell R, Rees MCP. (2006) Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothelial cells and induce its desensitisation via different mechanisms. Journal of Cell Science, 119(5), 910-922. Nikitenko LL, Cross T, Campo L, Leek R, Helen T, Manek S, Bicknell R, Rees MCP. (2006) Expression of terminally glycosylated calcitonin receptor-like receptor in uterine leiomyoma: endothelial phenotype and association with microvascular density. Clinical Cancer Research, 12(19), 5648-58. Nikitenko LL, Fox S, Kehoe S, Rees MCP, Bicknell R. (2006) Adrenomedullin and tumour angiogenesis. British Journal of Cancer, 94, 1-7. Carroll VA, Nikitenko LL, Bicknell R., Harris AL. (2005) Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2. Arteriosclerosis, Thrombosis and Vascular Biology, 25(4), 736-41.