Maher, Stephen - University of Hull - Department of Biology / Biomedical Sciences

个人简介

Senior Lecturer in Biomedical Science (2012–present): Dept. Biological Sciences, University of Hull, UK. Adjunct Associate Professor (2012–present): Dept. Surgery, Trinity College Dublin, Ireland. Irish Cancer Society Research Fellow (2010–2012): Dept. Surgery, Trinity College Dublin, Ireland. Research Fellow (2007–2010): Dept. Surgery, Institute of Molecular Medicine, Trinity College Dublin, Ireland. Visiting Post-doctoral Fellow (2004–2007): Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, National Institutes of Health, MD, USA. Locum Biochemist (2004–2004): Dept. Endocrinology, Beaumont Hospital, Dublin. Ph.D. student (2000–2004): Dept. Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

研究领域

The focus of my laboratory lies in translational gastrointestinal cancer biology and associated anti-cancer therapeutics. Currently, we have active research strands in: (1) the role of oesophageal cancer stem cells and their biology in conferring resistance to radiation, (2) the relationship of mitochondrial dysfunction and cellular bioenergetic plasticity to radioresistance, (3) microRNA species as regulators of sensitivity to chemotherapy and radiation in oesophageal adenocarcinoma and mesothelioma and (4) the role of CCL28 during the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence in the oesophagus. The groups has close links with Trinity College Dublin, St. James’s Hospital Dublin, Castle Hill Hospital Hull and Hull Royal Infirmary for translational, patient-orientated research.

近期论文

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Picardo SL, Maher SG, O’Sullivan J, Reynolds JV. Barrett’s to oesophageal cancer sequence: A model of inflammatory-driven upper gastrointestinal cancer. Dig Surg. 2012;29:251-260. Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, Maher SG. microRNA-31 modulates tumour sensitivity to radiation in oesophageal cancer. J Mol Med;2012;90:1449-1458. Maher SG and Reynolds JV. Oesophageal cancer: The potential of modern molecular tools in treatment. Cancer Professional. 2012;6:21-25. Lynam-Lennon N, Gray SG, Maher SG. miRNA in oncogenesis, in Epigenetics in human disease. Trygve O. Tollefsbol (Ed), Elsevier, 2012:89-110. Hötte GJ, Lynam-Lennon N, Reynolds JV, Maher SG. Radiation sensitivity of oesophageal adenocarcinoma: The contribution of the RNA-binding protein RNPC1 and p21-mediated cell cycle arrest to radioresistance. Radiation Res. 2012;177:272-279. Maher SG, McDowell DT, Murphy SA, Collins BC, Gallagher WM, Reynolds JV. Serum proteomic profiling reveals that pre-treatment complement protein levels are predictive of esophageal cancer response to neoadjuvant chemoradiation. Ann Surg. 2011;254:809-817. Maher SG, Reynolds JV. Basic Concepts of Inflammation and its role in carcinogenesis, in Inflammation and Gastrointestinal Cancers (Series: Recent Results in Cancer Research). J. A. Z. Jankowski (Ed), Springer, 2011;185:1-34. Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG. Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma. Radiation Res. 2010;174:703-711. Byrne M, Reynolds JV, O’Donnell JS, Keogan M, White B, Byrne M, Murphy S, Maher SG, Pidgeon GP. Activation of the procoagulant response following neoadjuvant chemotherapy and radiation therapy, and long-term activation following major cancer surgery. Brit. J. Cancer. 2010;102:73-79. Miller CHT, Maher SG, Young HA. Clinical use of Interferon-g, in Cytokine therapies: Novel approaches for clinical indications. Ann NY Acad Sci, Donnelly RP (Ed), 2009;1182:69-79. Maher SG, Gillham CM, Duggan SP, Smyth PC, Miller N, Muldoon C, O’Byrne KJ, Sheils OM, Hollywood D, Reynolds JV. Gene expression microarray analysis predicts pathological response to neoadjuvant chemoradiotherapy of oesophageal cancer. Ann Surg. 2009;250:729-737. McDowell DT, Smith FM, Reynolds JV, Maher SG, Adida C, Crotty P, Gaffney EF, Hollywood D, Mehigan B, Stephens RB, Kennedy MJ. Increased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer. Int J Colorectal Dis. 2009;24:1261-1269. Lynam-Lennon N, Maher SG, Reynolds JV. The roles of microRNA in cancer and apoptosis. Biol. Rev. 2009;84:55-71.