Hardman, Matthew - University of Hull - Department of Biology / Biomedical Sciences

个人简介

Director of Research - School of Life Sciences, University of Hull 2016-Present Reader in Wound Healing, University of Hull 2016-Present Director EPSRC & MRC CDT in Regenerative Medicine, University of Manchester 2015-2016 Senior Lecturer, University of Manchester 2014-2016 The Edmund de Rothschild Senior Fellow in Ageing Research, University of Manchester 2010-2014 Research Into Ageing 30th Anniversary Research Fellow, University of Manchester 2007-2010

研究领域

Research in the Hardman group aims to understand the causes of human pathological wound healing. We have extensive experience in wound biology where we employ a range of models including: In vitro functional assays In vivo wound models Ex vivo wound models Microbiological assays Microarrays and RNAseq Molecular, cellular and proteomic analyses

近期论文

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Yeung C-YC., Holmes DF, Thomason HA, Stephenson C, Derby B, *Hardman MJ. . (2016) An ex vivo porcine skin model to evaluate pressure-reducing devices of different mechanical properties used for pressure ulcer prevention. Wound Repair Regen in press. Wilkinson H, McBain A, Stephenson C, *Hardman MJ. (2016) Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model. Adv in Wound Care April 2016, ahead of print. Crompton R, Williams H, Cruickshank S, *Hardman MJ. (2016) Estrogen promotes healing in an LPS bacterial model of delayed cutaneous wound repair. Lab Invest. vol. 96 p.439-49 Garcin CL, Huttner KM, Kirby N, Schneider P, *Hardman MJ. (2016) Ectodysplasin A pathway contributes to human and murine wound repair. J Invest Dermatol. Vol.136 p.1022-30 Garcin CL, Ansell DM, Headon DJ, Paus R, *Hardman MJ. (2016) Hair follicle bulge stem cells appear dispensable for the acute phase of wound re-epithelialisation. Stem Cells. Vol. 34 p.1377-85 Ansell DM, *Hardman MJ. (2016) Do not be alarmed: understanding IL33-ST2 signalling in wound repair. Exp Dermatol. 25:22-3 Cooper NH, Balachandra JP, *Hardman MJ (2015) Global Gene Expression Analysis in PKCα(-/-) Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue. J Invest Dermatol. vol 135 p.3173-82 Campbell L, Emmerson E, Williams H, Saville CR, Davies F, Krust A, Chambon P, Mace KA, *Hardman MJ (2014) Inflammatory cell-specific ER-alpha deletion delays wound healing via impaired macrophage polarisation. J Invest Dermatol vol 134 p. 2447-2457. Ansell DM, Campbell L, Thomason HA, Brass A, *Hardman MJ. (2014) A statistical analysis of murine incisional and excisional acute wound models. Wound Repair Regen vol 22 p. 281-287 Mills SJ, Farrar MD, Ashcroft GS, Griffiths CEM, Hardman MJ, Rhodes LE (2014) Topical PDT following excisional wounding of human skin increases production of TGF-β3, MMP-1 and MMP-9 with associated improvement in dermal matrix organisation. British Journal of Dermatology vol 171 p. 55-62. Bannon P, Wood S, Restivo T, Campbell L, Hardman MJ, Mace KA. (2013) Diabetes induces stable intrinsic changes to myeloid cells that contribute to chronic inflammation during wound healing in mice. Dis Model Mech. vol 6 p. 1434-1447 Meier NT, Haslam IS, Pattwell DM, Zhang GY, Emelianov V, Paredes R, Debus S, Augustin M, Funk W, Amaya E, Kloepper JE, Hardman MJ, Paus R. (2013) Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin. PLoS One. 2013 vol 8, e73596. Emmerson E, Rando G, Meda C, Campbell L, Maggi A, *Hardman MJ. (2013) Estrogen receptor-mediated signalling in female mice is locally activated in response to wounding. Mol Cell Endocrinol. vol. 375, p. 149-156. Campbell L, Saville CR, Murray PJ, Cruickshank SM, *Hardman MJ (2013) Local arginase 1 activity is required for cutaneous wound healing. J Invest Dermatol. vol. 133 p. 2461-2470. Campbell L, Williams H, Crompton RA, Cruickshank SM, *Hardman MJ. (2013) Nod2 deficiency impairs inflammatory and epithelial aspects of the cutaneous wound-healing response. J Pathol. vol. 229, p. 121-131.