Greenman, John - University of Hull - Department of Biology / Biomedical Sciences

个人简介

BSc (Hons) Pathobiology (with Chemistry) (1987) University of Reading Doctor of Philosophy (Immunochemistry), (1991) University of Southampton 1990-1991 Post-doctoral Research Fellow, Tenovus Cancer Research Unit, University of Southampton 1991–1995 Post-doctoral Research Fellow, Sir William Dunn School of Pathology, MRC Cellular Immunology Unit, University of Oxford 1995-1999 Lecturer in Immunology, Dept of Surgery, University of Hull 1999-2004 Senior Lecturer in Tumour Immunology, University of Hull 2004- 2009 Reader in Tumour Immunology, University of Hull

研究领域

Coming from an immunology background I am extremely interested in understanding how the immune system is often subverted during carcinogenesis, and more importantly how such knowledge can be used clinically (diagnostically, prognostically or therapeutically). A novel way to combine investigations of both tumour biology and the anti-tumour response is with the advent of an innovative, microfluidic model system for handling tumour tissue that I am developing together with colleagues in Chemistry. This technology is allowing us to study specific cellular and molecular interactions in real-time in a tissue biopsy, rather than using disaggregated cells. A second research group focuses on the Immunobiology of Head & Neck Cancer. This unit benefits from the excellent links that have been forged with the surgical unit in Hull, and is based in the Daisy laboratories at Castle Hill Hospital.l. The aim is to characterise the systemic and intra-tumoural cytokine repertoires together with the enumeration and functional assessment of T regulatory cells; and then correlate these biological parameters with clinical outcome.

近期论文

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Wallis, SP., Stafford, ND., Greenman, J. (2014) The clinical relevance of immune parameters in the tumour microenvironment of head and neck cancers. Head & Neck (in press) Echrish HH., Xiao Y., Madden LA., Allgar V., Cooke J., Wedgwood K., Dasgupta D., Greenman J., Maraveyas A. (2014) Effect of resection of localized pancreaticobiliary adenocarcinoma on angiogenic markers and tissue factor related pro-thrombotic and pro-angiogenic activity. Thromb Res. doi: 10.1016/j.thromres.2014.05.022. Pacelli, A., Greenman, J., Cawthorne, C., Smith, G. (2014) Imaging COX-2 expression in cancer using PET/SPECT radioligands: Current status and future directions. Journal of Labelled Compounds and Radiopharmaceuticals 57 (4) 317-322 Carr, S., Green, VL., Stafford, ND., Greenman, J. (2013) Analysis of radiation-induced cell death in HNSCC and rat liver maintained in microfluidic devices. Otolaryngology – Head and Neck Surgery 150 (1) 73-80. Drennan, S., Stafford, ND., Greenman, J., Green, VL. (2013) Increased frequency and suppressive activity of CD127low/- Tregs in the peripheral circulation of patients with head and neck squamous cell carcinoma are associated with advanced stage and nodal involvement. Immunology 140 (3) 335-343. Shaw, K., Hughes, E., Dyer, C., Greenman, J., Haswell, S. (2013) Integrated RNA extraction and RT-PCR for semi-quantitative gene expression studies on a microfluidic device. Laboratory Investigation 93(8):961-6. doi: 10.1038/labinvest.2013.76. Suppiah, A., Greenman, J. (2013) Clinical utility of anti-p53 auto-antibody: Systematic review and Focus on Colorectal Cancer. World Journal of Gastroenterology 19(29):4651-70. doi: 10.3748/wjg.v19.i29.4651. Yousaf, J., Hills, C., Dixit, S., Achawal, S., O’Brien, D., Greenman, J. Scott, IS. (2013) Markers of cell division cycle in Glioblastoma-significance in prediction of treatment response and patient prognosis. British Journal of Neurosurgery (in press). Green, V.L., Michno, A., Stafford, N.D., Greenman, J. (2013). Increased prevalence of tumour infiltrating immune cells in oropharyngeal tumours in comparison to other subsites: relationship to peripheral immunity Cancer Immunol. Immunother. DOI. 10.1007/s00262-013-1395-9. Date, K., Hall, J., Greenman, J., Maraveyas, A., Madden, LA. (2013) Tumour and microparticle tissue factor expression and cancer thrombosis. Thrombosis Research 131(2):109-15. doi: 10.1016/j.thromres.2012.11.013. Sylvester, D., Hattersley, SM., Stafford, ND., Haswell, SJ., Greenman, J. (2013) Development of microfluidic-based analytical methodology for studying the effects of chemotherapy agents on cancer tissue. Current Analytical Chemistry - Bioanalysis in Microscale Bioengineering 9 (1) 2-8. Madden LA, Hayman YA, Underwood C, Vince RV, Greenman J, Allsup D, Ali S. (2012) Increased inducible heat shock protein 72 expression associated with PBMC isolated from patients with haematological tumours. Scand J Clin Lab Invest. 72(5): 380-6. doi: 10.3109/00365513.2012.681683 Kemp, C., Birch, C., Shaw, KJ., Nixon, G.J., Docker, PT., Greenman, J., Huggett, JF., Haswell, SJ., Foy, CA., Dyer, CE. (2012) Direct processing of clinically relevant large volume samples for the detection of sexually transmitted infectious agents from urine on a microfluidic device. Anal Methods 4: 2141-2144. Yates KR, Welsh J, Udegbunam NO, Greenman J,Maraveyas A,Madden LA. (2012) Duramycin exhibits antiproliferative properties and induces apoptosis in tumour cells. Blood Coagul Fibrinolysis. 23(5): 396-401 Khan, JA., Rahman, MN., Mazari, FA., Shahin, Y., Smith, G., Madden, L., Fagan, MJ., Greenman, J., McCollum, PT., Chetter IC (2012) Intraluminal Thrombus has a Selective Influence on Matrix Metalloproteinases and Their Inhibitors (Tissue Inhibitors of Matrix Metalloproteinases) in the Wall of Abdominal Aortic Aneurysms. Ann Vasc Surg. 26(3) 322-29 Welsh, J., Smith, JD., Yates, KR., Greenman, J., Maraveyas, A., Madden, LA. (2012) Tissue factor expression determines tumour cell coagulation kinetics. International Journal of Laboratory Hematology 34(4):396-402. doi:10.1111/j.1751-553X.2012.01409.x Cheah, L-T., Fritsch, I., Haswell, SJ., Greenman, J. (2012) Evaluation of Heart Tissue Viability under Redox-Magnetohydrodynamic Conditions: Toward Fine-Tuning Flow in Biological Microfluidic Applications. Biotechnology and Bioengineering 109(7): 1827-1834. Green, VL., Irune, E., Prasai, A., Alhamarneh, O., Greenman, J., Stafford, N. (2012) Serum IL10, IL12 and circulating CD4+CD25high T regulatory cells in relation to long-term clinical outcome in head and neck squamous cell carcinoma patients. Int J. Oncol. 40(3): 833-839. Green, VL., Michno, A., Greenman, J., Stafford, ND. (2011) Effect of treatment on systemic cytokines in head and neck squamous cell carcinoma patients. Results in Immunology pp. 1-6 DOI information: 10.1016/j.rinim.2011.12.001 Tanweer, F., Green, VL., Stafford, ND., Greenman, J. (2011) Application of Microfluidic Systems in Head and Neck Cancer Management. DOI: 10.1002/hed.22906.