个人简介
韩铮,男,浙江大学博士,比利时根特大学博士,研究员,上海市农业科学院农产品质量标准与检测技术研究所书记/副所长,上海市农业科学院真菌毒素风险评估卓越团队负责人。入选上海市农业领军人才、上海闵行领军人才(上海领军人才“后备队”)、农业农村部杰出青年农业科学家、上海市青年拔尖人才,获上海青年“五四奖章”等。
主要成果:主持国家自然科学基金(3项)、十三五重点攻关子课题、上海市科技兴农重点攻关项目、上海市科委仪器试剂专项等多项国家及省部级课题。以第一发明人授权国家发明专利12项;主持研制真菌毒素国家标准物质13项。发表论文100余篇,其中主笔发表SCI论文53篇,他引1500余次,1区35篇,单篇影响因子大于9的11篇。主持获得神农中华农业科技奖二等奖1项(2021-1),作为主要完成人获得省科学技术一等奖1项(2020-4)、中国粮油学会科学技术一等奖1项(2021-4)。
研究领域
围绕农产品和食品中真菌毒素的发生和防控开展了系统的研究工作:(1)创建了真菌毒素标准物质制备技术体系,攻克了我国真菌毒素标准物质缺乏、长期依赖进口、制约食品安全防控工作开展的困境;(2)提出了真菌毒素风险评价新策略,解决了同种食品和农产品容易被多种真菌毒素污染、但不同毒素的联合风险难以评估的难题;(3)发明了一系列特异性识别元件和纳米探针,突破了真菌毒素快速高效检测的技术瓶颈。
近期论文
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1. Zhiqi Zhang, Kai Fan, Jiajia Meng, Dongxia Nie, Zhihui Zhao, Zheng Han*. Deoxynivalenol hijacks the pathway of Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT-3) to drive caspase-3-mediated apoptosis in intestinal porcine epithelial cells. Science of the Total Environment, 2023, 864, 161058 (IF=10.753).
2. Qingwen Huang, Wenbo Guo, Xiuying Zhao, Haojie Cao, Kai Fan, Jiajia Meng, Dongxia Nie, Yongjiang Wu, Zheng Han*. Universal screening of 200 mycotoxins and their variations in stored cereals in Shanghai, China by UHPLC-Q-TOF MS, Food Chemistry, 2022, 387, 132869. (IF=9.231).
3. Dongxia Nie1, Zhiqi Zhang1, Dakai Guo, Yupeng Tang, Xiuli Hu, Qingwen Huang, Zhihui Zhao, Zheng Han*. A flexible assay strategy for non-glucose targets based on sulfhydryl-terminated liposomes combined with personal glucometer, Biosensors and Bioelectronics, 2021, 175, 112884.(IF=12.545)
4. Dongxia Nie1, Dakai Guo1, Qingwen Huang, Wenbo Guo, Jianhua Wang, Zhihui Zhao, Zheng Han*, A novel insight into fluorescent sensor for patulin detection using thiol-terminated liposomes with encapsulated coumarin-6 as signal probe, Sensors and Actuators: B. Chemical 2021, 345, 130366.(IF=9.221)
5. Zheng Han1, Zhanmin Tang1, Keqiu Jiang, Qingwen Huang, Jiajia Meng, Dongxia Nie, Zhihui Zhao*, Dual-target electrochemical aptasensor based on co-reduced molybdenum disulfide and Au NPs (rMoS2-Au) for multiplex detection of mycotoxins, Biosensors and Bioelectronics, 2020, 150, 111894. (IF=12.545)
6. Li Liu, Qingwen Huang, Zafar Iqbal Tanveer, Keqiu Jiang, Jinghui Zhang, Hongye Pan, Lianjun Luan, Xuesong Liu, Zheng Han*, Yongjiang Wu*. “Turn off-on” fluorescent sensor based on quantum dots and self-assembled porphyrin for rapid detection of ochratoxin A. Sensors and Actuators B: Chemical, 2020, 302, 127212.(IF=9.221)
7. Zhiqi Zhang1, Dongxia Nie1, Kai Fan, Junhua Yang, Wenbo Guo, Jiajia Meng, Zhihui Zhao, Zheng Han*. A systematic review of plant-conjugated masked mycotoxins: Occurrence, toxicology, and metabolism. Critical Reviews in Food Science and Nutrition, 2020, 60, 1523-1537. (IF=11.208)
8. Qingwen Huang1, Zhihui Zhao1, Dongxia Nie, Keqiu Jiang, Wenbo Guo, Kai Fan, Zhiqi Zhang, Jiajia Meng, Yongjiang Wu*, Zheng Han*, Molecularly imprinted poly(thionine)-based electrochemical sensing platform for fast and selective ultratrace determination of patulin, Analytical Chemistry, 2019, 91, 4116-4123. (IF=8.008)
9. Keqiu Jiang1, Dongxia Nie1, Qingwen Huang, Kai Fan, Zhanmin Tang, Yongjiang Wu*, Zheng Han*, Thin-layer MoS2 and thionin composite-based electrochemical sensing platform for rapid and sensitive detection of zearalenone in human biofluids, Biosensors and Bioelectronics, 2019, 130: 322-329. (IF=12.545)
10. Kai Fan1, Juan juan Xu1, Keqiu Jiang, Xing Liu, Jiajia Meng, Jose Diana Di Mavungu, Wenbo Guo, Zhiqi Zhang, Jun Jing, Hongru Li, Bing Yao, Hui Li, Zhihui Zhao, Zheng Han*. Determination of multiple mycotoxins in paired plasma and urine samples to assess human exposure in Nanjing, China, Environmental Pollution, 2019, 248: 865-873.(IF=9.988)
学术兼职
中国毒理学会理事、上海农学会理事、上海市食品学会食品安全专业委员会副主任委员、国家标准物质评审专家组成员,Front Chem、Toxins的副编辑、编委和客座编辑,上海海洋大学、上海理工大学、上海师范大学和上海应用技术大学研究生导师。