Cawkwell, Lynn - University of Hull - Department of Biology / Biomedical Sciences

个人简介

2015 Fellow of the Higher Education Academy 2012 Senior Lecturer, Department of Biological Sciences, University of Hull. 2003 to 2012 Senior Lecturer, Postgraduate Medical Institute, University of Hull. 1999 to 2003 Lecturer, Postgraduate Medical Institute, University of Hull. 1998 to 1999 Research Fellow, Molecular Oncology, Algernon Firth Institute of Pathology, University of Leeds. 1992 to 1998 Research Assistant, Molecular Oncology, Algernon Firth Institute of Pathology, University of Leeds. 1988 to 1992 Scientific Officer, CRC Department of Carcinogenesis, Paterson Institute for Cancer Research, Manchester. 1998 PhD (Molecular Oncology), School of Medicine, University of Leeds. 1988 BSc (Hons) Genetics, University of Liverpool.

研究领域

My research is based on the application of cancer proteomics to: identify biomarkers of response to anticancer therapy identify novel therapy targets or therapy strategies investigate the molecular mechanism of action of novel anticancer agents

近期论文

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E Kashuba, G L Eagle, J Bailey, P Evans, K J Welham, D Allsup, L Cawkwell. Proteomic analysis of B-cell receptor signalling pathways in chronic lymphocytic leukaemia reveals a possible role for kininogen. Journal of Proteomics 91: 478-485 (2013). V Agarwal, V C Hodgkinson, G L Eagle, L Scaife, M J Lind, L Cawkwell. Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697. International Journal of Oncology 42:1088-1092 (2013). V C Hodgkinson, V Agarwal, D ELFadl, J N Fox, P L McManus, T K Mahapatra, P J Kneeshaw, P J Drew, M J Lind, L Cawkwell. Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer. Journal of Proteomics 75: 2745-2752 (2012). V C Hodgkinson, D ELFadl, V Agarwal, V Garimella, C Russell, E D Long, J N Fox, P L McManus, T K Mahapatra, P J Kneeshaw, P J Drew, M J Lind, L Cawkwell. Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID? Journal of Proteomics 75: 1276-1283 (2012). V C Hodgkinson, D ELFadl, P J Drew, M J Lind, L Cawkwell. Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis. Journal of Proteomics. 74: 698-703 (2011). V Agarwal, M J Lind, L Cawkwell. Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand? Cancer Treatment Reviews 37: 533-542 (2011). L Smith, O Qutob, M B Watson, A W Beavis, D Potts, K J Welham, V Garimella, M J Lind, P J Drew, L Cawkwell. Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome? Neoplasia 11:1194-1207 (2009).