Beltran-Alvarez, Pedro - University of Hull - Department of Biology / Biomedical Sciences

个人简介

2015 Lecturer Biomedical Sciences, Hull University 2009 Post Doc Cardiovascular Genetics Centre, Girona ,Spain. 2008 PhD University of Bristol

研究领域

Protein post-translational modifications are like the “clothing” of proteins: dynamic, reversible. My group is interested in how proteins post-translational modifications change during cardiac disease, e.g. heart failure and atrial fibrillation. Within the 200 or so known post-translational modifications, we are particularly interested in arginine methylation, phosphorylation, and N-terminal acetylation. We look at post-translational modifications both from a systems biology approach (proteome level), and from a reductionist approach (often using NaV1.5 as a model system). We use a range of biochemical and molecular biology techniques, often including mass spectrometry and proteomic approaches.

近期论文

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Onwuli DO, Beltran-Alvarez P. An update on transcriptional andpost-translational regulation of brain voltage-gated sodium channels. AminoAcids. 2015 Oct 27. [Epub ahead of print] PubMed PMID: 26503606. Beltran-Alvarez P, Feixas F, Osuna S, Díaz-Hernández R, Brugada R, Pagans S.Interplay between R513 methylation and S516 phosphorylation of the cardiacvoltage-gated sodium channel. Amino Acids. 2015 Feb;47(2):429-34. doi:10.1007/s00726-014-1890-0. Epub 2014 Dec 16. PubMed PMID: 25501501. Beltran-Alvarez P, Tarradas A, Chiva C, Pérez-Serra A, Batlle M, Pérez-VillaF, Schulte U, Sabidó E, Brugada R, Pagans S. Identification of N-terminal proteinacetylation and arginine methylation of the voltage-gated sodium channel inend-stage heart failure human heart. J Mol Cell Cardiol. 2014 Nov;76:126-9. doi:10.1016/j.yjmcc.2014.08.014. Epub 2014 Aug 27. PubMed PMID: 25172307. Beltran-Alvarez P, Espejo A, Schmauder R, Beltran C, Mrowka R, Linke T, BatlleM, Pérez-Villa F, Pérez GJ, Scornik FS, Benndorf K, Pagans S, Zimmer T, BrugadaR. Protein arginine methyl transferases-3 and -5 increase cell surface expressionof cardiac sodium channel. FEBS Lett. 2013 Oct 1;587(19):3159-65. doi:10.1016/j.febslet.2013.07.043. Epub 2013 Jul 31. PubMed PMID: 23912080. Beltran-Alvarez P, Pagans S, Brugada R. The cardiac sodium channel ispost-translationally modified by arginine methylation. J Proteome Res. 2011 Aug5;10(8):3712-9. doi: 10.1021/pr200339n. Epub 2011 Jul 18. PubMed PMID: 21726068.