研究领域
Biological Chemistry
Research interests are based around the development of metal complexes as potential therapeutic agents and understanding their chemistry in biological systems.
Ru(η6-arene) anticancer compounds
One major focus is the development of novel organometallic ruthenium complexes as potential anticancer agents. The established [Ru(η6-arene)Cl2(PTA)] (RAPTA)1,2 and [Ru(η6-arene)(en)Cl]+ (RAED)3 compounds have clearly demonstrated that the Ru(η6-arene) framework can yield complexes with high activity against primary and secondary tumours. We intend to extend the structural diversity of Ru(η6-arene) compounds with the aim of improving selectivity and activity against metastasis.
Carbon Monoxide-Releasing Molecules (CO-RMs)
The recognition of carbon monoxide (CO) as a cytoprotective and homeostatic molecule has led to intensive investigation into its potential as a therapeutic agent. Gaseous CO administration has found applications in animal models for the treatment of a range of diseases and has also been examined in human clinical trials.4 However, the need for tissue specific delivery of CO has resulted in the development of carbon monoxide-releasing molecules (CO-RMs), often based on transition metal carbonyl compounds, which are designed to deliver and release CO in a controlled manner.5 We aim to develop metal-based CO-RMs which release CO on application of a suitable trigger, with the intention of investigating these compounds in biological systems.
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An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode, Z. Ma, G. Palermo, Z. Adhireksan, B. S. Murray, T. von Erlach, P. J. Dyson, U. Rothlisberger, C. A. Davey, Angew. Chem. Int. Ed., 2016.
The development of RAPTA compounds for the treatment of tumors, B. S. Murray, M. V. Brabak, C. G. Hartinger, P. J. Dyson, Coord. Chem. Rev., 2015, 306(1), 86-114.
Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro, B. S. Murray, S. Crot, S. Siankevich, P. J. Dyson, Inorg. Chem., 2014, 53, 9315–9321.
Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics, B. S. Murray, L. Menin, R. Scopelliti, P. J. Dyson, Chem. Sci., 2014, 5, 2536-2545.
Antiproliferative activities of trithiolato-bridged dinuclear arene osmium complexes, G. Gupta, N. Nagesh, B. S. Murray, P. J. Dyson, B. Therrien, Inorg. Chim. Acta,, 2014, 423A, 31-35.
Highly cytotoxic trithiolato-bridged dinuclear Rh(III) and Ir(III) complexes, G. Gupta, B. S. Murray, P. J. Dyson, B. Therrien, J. Organomet. Chem., 2014, 767, 78-82.
Synthesis, molecular structure and cytotoxicity of molecular materials based on water soluble half-sandwich Rh(III) and Ir(III) tetranuclear metalla-cycles, G. Gupta, B. S. Murray, P. J. Dyson, B. Therrien, Materials, 2013, 6, 5352-5366.
Synthesis, molecular structure, computational study and in vitro anti-cancer activity of dinuclear thiolato-bridged pentamethylcyclopentadienyl Rh(III) and Ir(III) complexes, G. Gupta, A. Garci, B. S. Murray, P. J. Dyson, G. Fabre, P. Trouillas, F. Giannini, J. Furrer, G. Suss-Fink, B. Therrien, Dalton Trans., 2013, 42, 15457-15463.
Investigating templating within polymer-scaffolded dynamic combinatorial libraries, C. S. Mahon, A. W. Jackson, B. S. Murray, D. A. Fulton, Polym. Chem., 2013, 4, 368-377.
Dynamic covalent single-chain polymer nanoparticles, B. S. Murray, D. A. Fulton, Macromolecules, 2011, 44, 7242-7252.
Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells, D. G. Smith, G. Law, B. S. Murray, R. Pal, D. Parker, K. Wong, Chem. Comm., 2011, 47, 7347-7349.
Templating a polymer-scaffolded dynamic combinatorial library, C. S. Mahon, A. W. Jackson, B. S. Murray and D. A. Fulton, Chem. Comm., 2011, 47, 7209-7211.
Reactive Thermoresponsive Copolymer Scaffolds, B. S. Murray, A. W. Jackson, C. Mahon and D. A. Fulton, Chem. Comm., 2010, 46, 8651-8653.
Synthesis, Chirality and Complexation Phenomena of Two Diastereoisomeric Dinuclear Lanthanide(III) Complexes, B. S. Murray, D. Parker, C. M. G. dos Santos and R. D. Peacock, Eur. J. Inorg. Chem., 2010, 18, 2663-2672.
Cell-penetrating metal complex optical probes: targeted and responsive systems based on lanthanide luminescence, C. P. Montgomery, B. S. Murray, E. J. New, R. Pal and D. Parker, Acc. Chem. Res., 2009, 42(7), 925-937.
Electron-capture dissociation and collision-induced dissociation of lanthanide metal-ligand complexes and lanthanide metal-ligand complexes bound to phosphopeptides, J. A. Mosely, B. S. Murray and D. Parker, Eur. J. Mass. Spectrom., 2009, 15(2), 145-155.
Critical evaluation of five emissive europium(III) complexes as optical probes: correlation of cytotoxicity, anion and protein affinity with complex structure, stability and intracellular localisation profile, B. S. Murray, E. J. New, R. Pal and D. Parker, Org. Biomol. Chem., 2008, 6, 2085-2094.
Two-photon absorption and photoluminescence of europium based emissive probes for bioactive systems, L.-O. Pålsson, R. Pal, B. S. Murray, D. Parker, and A. Beeby, Dalton Trans., 2007, 48, 5726-5734.
A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment, P. Atkinson, B. S. Murray and D. Parker. Org. Biomol. Chem., 2006, 4, 3166-3171.
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