吝易 - 清华大学 - 生命科学学院

个人简介

2005-2009年江南大学，学士 2009-2014年马凯特大学，博士 2014-2020年西南医学中心，博士后 2020年-至今清华大学生命科学学院，助理教授 2020年-至今清华大学生命科学联合中心、清华-IDG/麦戈文脑科学研究院，研究员荣誉、奖励及参加学术团体的情况 Oliver Smith Academic Achievement Award (2013) Marquette University Fellowship (2012-2014) Richard W. Jobling Award (2012-2013)

研究领域

人口老龄化的加剧使神经退行性疾病逐渐成为世界性健康难题。此类疾病的共同特征是特定蛋白质在脑部形成异常凝集。影响上述凝集过程的核心机制是蛋白质及其他生物大分子的相变：生理状态下，这些蛋白通过液液相变形成无膜细胞器，从而对细胞内空间进行分隔，精确协调各种生化反应；病理状态下，异常相变造成蛋白质不溶性聚集，进而导致神经元死亡。我们希望系统性地研究生物大分子相变的分子机制及其对神经系统功能的影响，最终达到通过人工干预调控病理状态下的相变，从而治疗神经退行性疾病的目的

近期论文

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Hongyao Sun#, Yutong Chen#, Kun Yan, Yanqiu Shao, Qiangfeng C Zhang, Yi Lin*, Qiaoran Xi*. Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs. (2023) The Embo Journal. Feb 1; 42(3):e112058 Xiang Shi#, Yanrong Zhuang#, Zhenhua Chen#, Mingrui Xu, Junqi Kuang, Xue-Lian Sun, Lisen Gao, Xia Kuang, Huairen Zhang, Wei Li, Samuel Zheng Hao Wong, Chuanyu Liu, Longqi Liu, Danhua Jiang, Duanqing Pei, Yi Lin*, QingFeng Wu*. Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset. (2022) Science Advances. Nov 16; 8(46):eabq2987 Yifei Gao#, Xi Li#, Pilong Li*, Yi Lin*. A brief guideline for studies of phase-separated biomolecular condensates. (2022) Nature Chemical Biology. Nov 18; 18(12):1307-1318 Yi Lin*, Xiaofeng Fang*. Phase separation in RNA biology. (2021) Journal of Genetics and Genomics. Oct 20; 48(10):872-880 Yi Lin, Xiaoming Zhou, Masato Kato, Daifei Liu, Sina Ghaemmaghami, Benjamin P. Tu, and Steven L. McKnight, Redox-mediated Regulation of an Evolutionarily Conserved Cross-β Structure Formed by the TDP43 LC Domain. (2020) PNAS. Nov 17;117(46):28727-28734 Yi Lin#, Eiichiro Mori#, Masato Kato#, Siheng Xiang#, Leeju Wu, Ilmin Kwon and Steven L. McKnight, Toxic PR Poly- Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. (2016) Cell. Oct 20; 167(3):789-802 Dylan T. Murray#, Masato Kato#, Yi Lin, Kent R. Thurber, Ivan Hung, Steven L. McKnight, and Robert Tycko, Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains. (2017) Cell. Oct 19; 171(3):615–627 Masato Kato, Yi Lin, Steven L. McKnight, Cross-β Polymerization and Hydrogel Formation by Low-Complexity Sequence Proteins. (2017) Methods. Aug 15; 126:3–11 Siheng Xiang, Masato Kato, Leeju C. Wu, Yi Lin, Ming Ding, Yajie Zhang, Yonghao Yu, Steven L. McKnight, The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei. (2015) Cell. Nov 5;163(4):829-39