个人简介

Mark got his BSc in Biochemistry from the University of Warwick. He then completed doctoral studies and a post-doc on protein folding at the University of Bristol. Next Mark moved to Goethe University in Frankfurt where he acquired (some of) the tricks of solid state NMR. In 2006 he took up an RCUK fellowship at the University of Hull, as a joint appointment between the departments of Chemistry and Biology. He was promoted to Senior Lecturer in in 2013 and Professor in 2016. In 2014 Mark was appointed Associate Dean for Engagement for the Faculty of Science and Engineering. Within this role he oversees the faculty’s international partnerships, student recruitment and public engagement activities. Mark is also the Director of the Hull Science Festival on sits on University Senate and Council. Mark is committed to science communication. He hosts the Beverley Science Cafe, holds regular family learning science workshops and has even been spotted doing kitchen chemistry in Hull's shopping centres. He was a UK national finalist of Famelab and has since appeared on BBC’s Coast, BBC Radio 4’s You and Yours, US public service radio and numerous regional radio and TV shows. Mark also has a talent for blogging and science journalism. He now blogs at Chemistry Blog for the chemical community and for everyone else in places such as The Guardian and The Conversation. His prose has also appeared in Nature Chemistry, The Hindu Times, Scientific American and Ars Technica.

研究领域

Biological Chemistry

Drug/lipid interactions Protein/membrane interactions in Amyloid disease Use of sporopollonin exines as surfactants and drug delivery devices My research focuses on the interactions that occur at and in lipid membranes. I am particularly interested in how drugs penetrate membranes on their way to their target site and also what affect the drug molecules have on the phase behaviour of lipid membranes. The Alzheimer's peptide beta -amyloid is also the subject of my research. Studying the interactions between this peptide and cell membranes may help us understand its involvement in Alzheimer's disease. As a sideline I've also got interested in using plant spores for biotech applications. It turns out that the exine shells around spores can be used as amazingly versatile microencapsulation devices with applications from drug delivery to taste masking and oil sequestration. Much of my research uses solid state NMR to probe the structure an function of these systems.

近期论文

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Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer M.De Poli, W.Zawodny, O.Quinonero, M.Lorch, S.JWebb, J.Clayden. Science. (2016) doi: 10.1126/science.aad8352 Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. B.P.Burke, N.Baghdadi, A.E.Kownacka, S.Nigam, G.S.Clemente, M.M.Al-Yassiry, J.Domarkas, M.Lorch, M.Pickles, P.Gibbs, R.Tripier, C.Cawthorne, S.J.Archibald,. Nanoscale. (2015) doi: 10.1126/science.aad8352 Whiter, brighter, and more stable cellulose paper coated with TiO 2/SiO2 core/shell nanoparticles using a layer-by-layer approach. F. Cheng, M. Lorch, S.M. Sajedin, S.M. Kelly & A. Kornherr. ChemSusChem. (2013) 6(8)1392-1399. Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking A. Diego-Taboada, L. Maillet, Banoub, J.H., M. Lorch, A.S. Rigby , A.N. Boa, S.L. Atkin, S.T. Beckett and G. MacKenzie. J. Mats. Chem. B. 2013 1(5) 707-713. A clerical error provides a unique opportunity to study the effect of previously seen exam questions on exam results. T.J. Prior and M. Lorch New Directions 2012 8, 49-52 DOI: 10.11120/ndir.2012.00080049 Sequestration of edible oil from emulsions using new single and double layered microcapsules from plant spores. J. Mats. Chem. A. Diego-Taboada, P. Cousson, E. Raynaud, Huang, Y., M. Lorch, B.P. Binks, Y. Queneau, A.N. Boa, S.L. Atkin, S.T. Beckett and G. MacKenzie. 2012 22(19) 9767-9773 Dynamic Nuclear Polarization-Enhanced Solid-State NMR of a 13C-labeled Signal Peptide Bound to Lipid-Reconstituted SEC Translocon. L. Reggie, J.J. Lopex, I. Collinson, C. Glaubitz and M. Lorch. J. Am. Chem. Soc., 2011 133(47) 19084-19086. doi: 10.1021/ja209378h Stabilizing membrane proteins in detergent and lipid systems in Robinson A.S. (eds) Production of membrane proteins: Stratgies for Expression and Isolation, New York,: Wiley 361-383 Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers, R. Batchelor, C.J. Windle, S. Buchoux and M. Lorch J. Biol. Chem., 2010, 285, 41402-41411. doi: 10.1074/jbc.M110.155176 Access to a primary aminosporopollenin solid support from plant spores, S. Barrier, A. Lobbert, A. J. Boasman, A. N. Boa, M. Lorch, S. L. Atkin, and G. Mackenzie, Green Chemistry, 2010, 12, 234-40. doi: 10.1039/b913215e MRI contrast agent delivery using spore capsules: controlled release in blood plasma, M. Lorch, M. J. Thomasson, A. Diego-Taboada, S. Barrier, S. L. Atkin, G. Mackenzie, and S. J. Archibald, Chem. Commun., 2009, 6442-4. doi: 10.1039/b909551a Lipid Unsaturation and Membrane Protein Has an Enormous Effect on the Gel Phase Hysteresis of Mixed Phospholipids, J. W. Jones, L. Lue, M. Lorch, A. Saiani, A. Tahlawi, and G. J. Tiddy, J. Cosmet. Sci., 2009, 60, 393-4. doi: Phosphatidylglycerol lipids enhance folding of an alpha helical membrane protein, A. M. Seddon, M. Lorch, O. Ces, R. H. Templer, F. Macrae, and P. J. Booth, J. Mol. Biol., 2008, 380, 548-56. doi: 10.1016/j.jmb.2008.05.001 Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR, N. Pfleger, M. Lorch, A. C. Woerner, S. Shastri, and C. Glaubitz, J. Biomol. NMR, 2008, 40, 15-21. doi: 10.1007/s10858-007-9203-5 Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes, J. J. Lopez and M. Lorch, J. Biol. Chem., 2008, 283, 7813-22. doi: 10.1074/jbc.M707480200 Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence, D. Basting, M. Lorch, I. Lehner, and C. Glaubitz, FASEB J., 2008, 22, 365-73. doi: 10.1096/fj.07-9162com Isothiocyanato-calix[4]phyrin-(1,1,1,1): a useful intermediate for the synthesis of derivatised anion sensors, S. C. Jha, M. Lorch, R. A. Lewis, S. J. Archibald, and R. W. Boyle, Org. Biomol. Chem., 2007, 5, 1970-4. doi: 10.1039/b703646a Crystal structure of 4-hexyl-4 '-hydroxyazobenzene isopropanol hemisolvate, C18H22N2O center dot 1/2C(3)H(8)O, H. R. Nasiri, M. Bolte, M. Lorch, and H. Schwalbe, Z. Krist.-New Cryst. Struct., 2006, 221, 219-20. doi: 10.1524/ncrs.2006.0046 Kinetics of an individual transmembrane helix during bacteriorhodopsin folding, E. L. R. Compton, N. A. Farmer, M. Lorch, J. M. Mason, K. M. Moreton, and P. J. Booth, J. Mol. Biol., 2006, 357, 325-38. doi: 10.1016/j.jmb.2005.12.042 Investigating transport proteins by solid state NMR, D. Basting, I. Lehner, M. Lorch, and C. Glaubitz, Naunyn-Schmiedebergs Arch. Pharmacol., 2006, 372, 451-64. doi: 10.1007/s00210-006-0039-4