个人简介

Dave graduated with a BSc, First Class Honours, in chemistry from Cardiff University in 1980 where he remained to obtain, in 1983, a PhD in organometallic chemistry working with Leon Kane-Maguire. He then undertook postdoctoral research in organometallic chemistry at the University of Arizona, USA, and in bioinorganic chemistry at the University of York. In 1986 he was appointed as a “new-blood” researcher at the Agricultural and Food Research Council, Unit of Nitrogen Fixation, based at the University of Sussex. In 1988 his position was complemented and he was promoted to Principal Research Scientist in 1994. In 1995 the Biotechnology and Biological Sciences Research Council, Nitrogen Fixation Laboratory (NFL), as it was then known, was relocated to the John Innes Centre (JIC), Norwich. In 2000 the NFL was disbanded and Dave joined the newly created JIC, Department of Biological Chemistry. Dave has held honorary academic positions at the University of East Anglia, Norwich, including Lecturer and later Reader in the School of Chemical Sciences and Pharmacy and, most recently, Professor in the School of Pharmacy. In summer 2012 Dave was appointed Professor of Biological Chemistry at the University of Hull, in July 2014 he was appointed Professor of Chemistry and Head of Department, and in August 2016 Head of the new School of Mathematics and Physical Sciences incorporating the subject groups of chemistry, mathematics and physics. For many years he has been a Fellow of the Royal Society of Chemistry and in 2013 was admitted as a Fellow to the Higher Education Academy.

研究领域

Biological Chemistry

Originally working in the AFRC/BBSRC Nitrogen Fixation Laboratory and John Innes Centre, Department of Biological Chemistry, Dave Evans has an established international reputation in the field of bioinorganic chemistry; especially the synthesis and characterisation of chemical models of the metal containing active sites of environmentally important enzymes such as the nitrogenases, hydrogenases, carbon monoxide dehydrogenase and acetyl-CoA synthase. Recently, he has developed a research programme in an area of bionanoscience that utilises plant viruses as nano-building blocks, scaffolds or templates. The research in this exciting, developing, multidisciplinary field sits at the interface of chemistry, biology, materials science and medicine. For example, Cowpea mosaic virus (CPMV) particles are 30 nm diameter naturally occurring nanoparticles with well characterised properties. CPMV is a natural, robust, nanoscale building block. The Evans Group has shown that inorganic, organometallic, organic and biomolecular moieties can be chemically linked to the virus surface and that the virus particles can be assembled into arrays on solid supports in a controlled fashion. In addition, several routes to the mineralisation of the external surface of the virus have been developed; providing methods for the preparation of narrowly disperse metallic nanoparticles by environmentally benign processes. Further, the internal cavity of empty virus-like particles, utilising capsids devoid of RNA, is being assessed as a carrier of cargo. These and related systems are being developed for applications such as targeted drug delivery, diagnostics and imaging.

近期论文

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Iron- and cobalt-catalysed synthesis of carbene-phosphinidenes, K. Pal, O. B. Hemming, B. M. Day, T. Pugh, D. J. Evans and R. A. Layfield, Angew. Chem. Int. Ed. 2015, 55, 1690-1693. doi:10.1002/anie.201508303 Structural insights into magnetic clusters grown inside virus capsids, M. Jaafar, A. A. A. Aljabali, I. Berlanga, R. Mas-Balleste, P. Saxena, S. Warren, G. P. Lomonossoff, D. J. Evans and P. J. de Pablo, ACS Appl. Mater. Interfaces, 2014, 6, 20936-20942. dx.doi.org/10.1021/am505682x CPMV-DOX delivers, A. A. A. Aljabali, S. Shukla, G. P. Lomonossoff, N. F. Steinmetz and D. J. Evans, Mol. Pharmaceutics, 2013, 10, 3-10. doi: 10.1021/mp3002057 Interior engineering of a viral nanoparticle and its tumour homing properties, A. M. Wen, S. Shukla, P. Saxena, A. A. A. Aljabali, I. Yildiz, S. Dey, J. E. Mealy, A. C. Yang, D. J Evans, G. P. Lomonossoff and N. F. Steinmetz, Biomacromolecules, 2012, 13, 3990-4001. doi: 10.1021/bm301278f Liquid viruses by nanoscale engineering of capsid surfaces, A. J. Patil, N. McGrath, J. E. Barclay, D. J. Evans, H. Colfen, I. Manners, A. W. Perriman and S. Mann, Adv. Mater., 2012, 24, 4557-63. doi: 10.1002/adma.201201032 Charge modified Cowpea mosaic virus particles for templated mineralization, A. A. A. Aljabali, J. E. Barclay, O. Cespedes, A. Rashid, S. S. Staniland, G. P. Lomonossoff, and D. J. Evans, Adv. Funct. Mater., 2011, 21, 4137-42. doi: 10.1002/adfm.201101048 Three-coordinate iron(II) expanded ring N-heterocyclic carbene complexes, J. J. Dunsford, D. J. Evans, T. Pugh, S. N. Shah, N. F. Chilton and M. J. Ingleson, Three-coordinate iron(II) expanded ring N-heterocyclic carbene complexes, Organometallics, 2016, 35, 1098-1106. doi:10.1021/acs.organomet.6b00121 Iron- and cobalt-catalysed synthesis of carbene-phosphinidenes, K. Pal, O. B. Hemming, B. M. Day, T. Pugh, D. J. Evans and R. A. Layfield, Angew. Chem. Int. Ed. 2015, 55, 1690-1693. doi:10.1002/anie.201508303 Synthesis and characterisation of halide, separated ion pair, and hydride cyclopentadienyl iron bis(diphenylphosphino)ethane derivatives,D. Patel, A. Wooles, A.D. Cornish, L. Steven, E. S. Davies, D. J. Evans, J. McMaster, W. Lewis, A. J. Blake and S. T. Liddle, Dalton Trans., 2015, 44, 14159-14177. doi:10.1039/c5dt00704f Bionanomaterials from plant viruses, A. A. A. Aljabali and D. J. Evans in Viral Nanotechnology, Y. Khudyakov and P. Pumpens (eds), 2015 CRC Press. ISBN 9781466583528 Doping of inorganic materials in microreactors – preparation of Zn doped Fe3O4 nanoparticles, M. D. Simmons, N. Jones, D. J. Evans, C. Wiles, P. Watts, S. Salamon, M. Escobar Castillo, H. Wende, D. C. Lupascu and M. G. Francesconi, Lab Chip, 2015, 15, 3154-3162. doi: 10.1039/c5lc00287g Structural Insights into Magnetic Clusters Grown Inside Virus Capsids. M. Jaafar, A. A. A. Aljabali, I. Berlanga, R. Mas-Balleste, P. Saxena, S. Warren, G. P. Lomonossoff, D. J. Evans and P. J. de Pablo, ACS Appl. Mater. Interfaces, 2014, 6, 20936-20942.dx.doi.org/10.1021/am505682x Direct amine-functionalisation of γ-Fe2O3 nanoparticles, V. Rocher, J. Manerova, M. Kinnear, D. J. Evans and M. G. Francesconi, Dalton Trans., 2014, 43, 2948-2952. doi: 10.1039/c3dt52386a Genetic engineering and characterization of Cowpea Mosaic Virus empty virus-like particles, F. Sainsbury, P. Saxena, A. A. A. Aljabali, K. Saunders, D. J. Evans and G. P. Lomonossoff , in Virus Hybrids as Nanomaterials: Methods and Protocols, Methods in Molecular Biology, 2014, 1108, B. Lin and B. Ratna (eds), Chapter 11, pp 139-153. doi: 10.1007/978-1-62703-751-8_11 Polyelectrolyte-modified Cowpea Mosaic Virus for the synthesis of gold nanoparticles, A. A. A. Aljabali and D. J. Evans, in Virus Hybrids as Nanomaterials: Methods and Protocols, Methods in Molecular Biology, 2014, 1108, B. Lin and B. Ratna (eds), Chapter 7, pp 97-103. doi: 10.1007/978-1-62703-751-8_7 Templated mineralization by charge-modified Cowpea Mosaic Virus, A. A. A. Aljabali and D. J. Evans, in Virus Hybrids as Nanomaterials: Methods and Protocols, Methods in Molecular Biology, 2014, 1108, B. Lin and B. Ratna (eds), Chapter 6, pp 89-95. doi: 10.1007/978-1-62703-751-8_6 Applications of plant viruses in bionanotechnology, G. P. Lomonossoff and D. J. Evans, in Current Topics in Microbiology and Immunology: Plant Viral Vectors, 2014, 375, K. Palmer and Y. Gleba (eds), pp 61-87. doi: 10.1007/82_2011_184 Normal-to-abnormal rearrangement and NHC activation in three-coordinate iron(II) carbene complexes, B. M. Day, T. Pugh, D. Hendriks, C. F. Guerra, D. J. Evans, F. M. Bickelhaupt and R. A. Layfield, J. Am. Chem. Soc., 2013, 135, 1338-13341.doi: 10.1021/ja408589p CPMV-DOX delivers, A. A. A. Aljabali, S. Shukla, G. P. Lomonossoff, N. F. Steinmetz and D. J. Evans, Mol. Pharmaceutics, 2013, 10, 3-10. doi: 10.1021/mp3002057