个人简介

Ross gained his BSc in chemistry from Paisley College, Scotland, in 1986, and remained in Paisley for his PhD in organic photochemistry under the supervision of George Truscott. In 1990 he moved to Canada where he carried out postdoctoral research, first at the MRC Group in Radiation Sciences, Universite de Sherbrooke, Quebec, with Johan van Lier, and then at University of British Columbia, Vancouver with David Dolphin. In 1996 Ross returned to the UK to take up the post of Lecturer in Biological Chemistry, at University of Essex, and in 2000 moved to his present post as Reader in Biological Chemistry, University of Hull.

研究领域

Biological Chemistry

My major interest is in the synthesis and applications of light active molecules, primarily in the area of biomedical science. My research group works closely with biomedical scientists and clinicians on an emerging cancer treatment called photodynamic therapy (PDT). PDT involves the administration of a tumour selective drug that is not toxic until activated by light of a specific colour, usually red. The ability to selectively activate the drug in the tumour avoids many of the side effects associated with chemo- and radiotherapy. In a related area we are synthesising novel photoactive nanoparticles, which can be used to study the effects of reactive oxygen species (ROS) in cells. ROS are implicated in ageing, carcinogenesis, heart disease and Alzheimer’s disease. Techniques routinely used in my research include organic synthesis, UV-visible and fluorescence spectroscopy, bioconjugation, tissue culture and fluorescence microscopy. Since moving to Hull my research has received generous funding from EPSRC, BBSRC, Wellcome Trust, Leverhulme Trust, EU and the Royal Society. Research interests Synthetic chemistry of porphyrins and related molecules Photodynamic therapy of cancer and other diseases Fluorescent probes Conjugation of photoactive species to biomolecules

近期论文

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Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species, L. B. Josefsen, J. W. Aylott, A. Beeby, P. Warburton, J. P. Boyle, C. Peers, and R. W. Boyle, Photochem. Photobiol. Sci., 2010, 9, 801-11. doi: 10.1039/c0pp00004c Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives, S. Jha, J. D. Silversides, R. W. Boyle, and S. J. Archibald, Crystengcomm, 2010, 12, 1730-9. doi: 10.1039/b924683e Site-Specific and Stoichiometric Conjugation of Cationic Porphyrins to Antiangiogenic Monoclonal Antibodies, C. M. A. Alonso, A. Palumbo, A. J. Bullous, F. Pretto, D. Neri, and R. W. Boyle, Bioconjugate Chem., 2010, 21, 302-13. doi: 10.1021/bc9003537 Glycerol and galactose substituted zinc phthalocyanines. Synthesis and photodynamic activity, Y. Zorlu, M. A. Ermeydan, F. Dumoulin, V. Ahsen, H. Savoie, and R. W. Boyle, Photochem. Photobiol. Sci., 2009, 8, 312-8. doi: 10.1039/b817348f Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species, L. B. Josefsen, J. W. Aylott, A. Beeby, P. Warburton, J. P. Boyle, C. Peers, and R. W. Boyle, Photochem. Photobiol. Sci., 2010, 9, 801-11. doi: 10.1039/c0pp00004c Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives, S. Jha, J. D. Silversides, R. W. Boyle, and S. J. Archibald, Crystengcomm, 2010, 12, 1730-9. doi: 10.1039/b924683e Site-Specific and Stoichiometric Conjugation of Cationic Porphyrins to Antiangiogenic Monoclonal Antibodies, C. M. A. Alonso, A. Palumbo, A. J. Bullous, F. Pretto, D. Neri, and R. W. Boyle, Bioconjugate Chem., 2010, 21, 302-13. doi: 10.1021/bc9003537 Glycerol and galactose substituted zinc phthalocyanines. Synthesis and photodynamic activity, Y. Zorlu, M. A. Ermeydan, F. Dumoulin, V. Ahsen, H. Savoie, and R. W. Boyle, Photochem. Photobiol. Sci., 2009, 8, 312-8. doi: 10.1039/b817348f Reductive Amination - A Convenient Method for Generating Diverse, Mono-Functionalised 5,10,15,20-Tetraphenyl Porphyrins, C. Welch, S. J. Archibald, and R. W. Boyle, Synthesis-Stuttgart, 2009, 551-6. doi: 10.1055/s-0028-1083335 Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand, R. E. Mewis, H. Savoie, S. J. Archibald, and R. W. Boyle, Photodiagnosis Photodyn. Ther., 2009, 6, 200-6. doi: 10.1016/j.pdpdt.2009.08.002 Mesogenic dipyrrins - building blocks for the fabrication of fluorescent and metal-containing materials, C. J. Wilson, L. James, G. H. Mehl, and R. W. Boyle, Chem. Commun., 2008, 4582-4. doi: 10.1039/b806672h Photodynamic therapy: novel third-generation photosensitizers one step closer?, L. B. Josefsen and R. W. Boyle, British Journal of Pharmacology, 2008, 154, 1-3. doi: 10.1038/bjp.2008.98 Development and characterization of novel photosensitizer : scFv conjugates for use in photodynamic therapy of cancer, C. Staneloudi, K. A. Smith, R. Hudson, N. Malatesti, H. Savoie, R. W. Boyle, and J. Greenman, Immunology, 2007, 120, 512-7. doi: 10.1111/j.1365-2567.2006.02522.x Isothiocyanato-calix[4]phyrin-(1,1,1,1): a useful intermediate for the synthesis of derivatised anion sensors, S. C. Jha, M. Lorch, R. A. Lewis, S. J. Archibald, and R. W. Boyle, Org. Biomol. Chem., 2007, 5, 1970-4. doi: 10.1039/b703646a Synthesis and in vitro investigation of cationic 5,15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers, N. Malatesti, K. Smith, H. Savoie, J. Greenman, and R. W. Boyle, Int. J. Oncol., 2006, 28, 1561-9. doi: Isothiocyanato boron dipyrromethenes - The first BODIPY analogues of fluorescein isothiocyanate, N. Malatesti, R. Hudson, K. Smith, H. Savoie, K. Rix, K. Welham, and R. W. Boyle, Photochem. Photobiol., 2006, 82, 746-9. doi: 10.1562/2005-01-10-ra-769 Synthetic routes to porphyrins bearing fused rings, S. Fox and R. W. Boyle, Tetrahedron, 2006, 62, 10039-54. doi: 10.1016/j.tet.2006.08.021 Development of phage derived scFv : porphyrin conjugates for use in photodynamic therapy of cancer, C. Staneloudi, K. A. Smith, R. Hudson, N. Pesa, H. Savoie, R. W. Boyle, and J. Greenman, Immunology, 2005, 116, 35-. doi: The development and characterisation of porphyrin isothiocyanate-monoclonal antibody conjugates for photoimmunotherapy, R. Hudson, M. Carcenac, K. Smith, L. Madden, O. J. Clarke, A. Pelegrin, J. Greenman, and R. W. Boyle, Br. J. Cancer, 2005, 92, 1442-9. doi: 10.1038/sj.bjc.6602517 Near IR emitting isothiocyanato-substituted fluorophores: their synthesis and bioconjugation to monoclonal antibodies, W. B. Duan, K. Smith, H. Savoie, J. Greenman, and R. W. Boyle, Org. Biomol. Chem., 2005, 3, 2384-6. doi: 10.1039/b504334d