Archibald, Steve J. - University of Hull

个人简介

I was awarded a first class BSc degree at the University of York in Chemistry, Life Systems and Pharmaceuticals in 1992. I continued my studies at the University of Edinburgh under the supervision of Profs. Richard Winpenny and Martin Schroder and was awarded a PhD in 1995. I spent two years as a PDRA with Prof. Daryle Busch at the University of Kansas followed by a further two and a half years at the University of York in Prof. Paul Walton's laboratory. I was appointed as a Lecturer at the University of Hull in 2000, promoted to Senior Lecturer in 2008, Reader in 2011and Professor in 2014. In 2013 I was appointed as the Director of the Positron Emission Tomography Research Centre at the University of Hull which became fully operational in summer 2014. This research facility carries out a range of studies spanning from isotope production to preclinical imaging.

研究领域

Biological Chemistry

My research interests focus on radiopharmaceutical compounds for medical imaging and targeted protein binding molecules for therapeutic applications. My group is multi-disciplinary with expertise in synthesis, medical imaging techniques and biological assays. Research interests Radiopharmaceutical imaging (positron emission tomography) Medicinal inorganic chemistry Anti-viral compounds Cancer therapeutics Protein binding metal complexes

近期论文

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Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole, A. E. Sparke, C. M. Fisher, R. E. Mewis, and S. J. Archibald, Tetrahedron Lett., 2010, 51, 4723-6. doi: 10.1016/j.tetlet.2010.07.010 Biomedical applications of macrocyclic ligand complexes, R. E. Mewis and S. J. Archibald, Coord. Chem. Rev., 2010, 254, 1686-712. doi: 10.1016/j.ccr.2010.02.025 Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives, S. Jha, J. D. Silversides, R. W. Boyle, and S. J. Archibald, Crystengcomm, 2010, 12, 1730-9. doi: 10.1039/b924683e A Cellular Screening Assay Using Analysis of Metal-Modified Fluorescence Lifetime, N. I. Cade, G. Fruhwirth, S. J. Archibald, T. Ng, and D. Richards, Biophys. J., 2010, 98, 2752-7. doi: 10.1016/j.bpj.2010.03.016 Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole, A. E. Sparke, C. M. Fisher, R. E. Mewis, and S. J. Archibald, Tetrahedron Lett., 2010, 51, 4723-6. doi: 10.1016/j.tetlet.2010.07.010 Biomedical applications of macrocyclic ligand complexes, R. E. Mewis and S. J. Archibald, Coord. Chem. Rev., 2010, 254, 1686-712. doi: 10.1016/j.ccr.2010.02.025 Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives, S. Jha, J. D. Silversides, R. W. Boyle, and S. J. Archibald, Crystengcomm, 2010, 12, 1730-9. doi: 10.1039/b924683e A Cellular Screening Assay Using Analysis of Metal-Modified Fluorescence Lifetime, N. I. Cade, G. Fruhwirth, S. J. Archibald, T. Ng, and D. Richards, Biophys. J., 2010, 98, 2752-7. doi: 10.1016/j.bpj.2010.03.016 Reductive Amination - A Convenient Method for Generating Diverse, Mono-Functionalised 5,10,15,20-Tetraphenyl Porphyrins, C. Welch, S. J. Archibald, and R. W. Boyle, Synthesis-Stuttgart, 2009, 551-6. doi: 10.1055/s-0028-1083335 Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand, R. E. Mewis, H. Savoie, S. J. Archibald, and R. W. Boyle, Photodiagnosis Photodyn. Ther., 2009, 6, 200-6. doi: 10.1016/j.pdpdt.2009.08.002 Synthesis and characterization of the chromium(III) complexes of ethylene cross-bridged cyclam and cyclen ligands, D. L. Maples, R. D. Maples, W. A. Hoffert, T. H. Parsell, A. van Asselt, J. D. Silversides, S. J. Archibald, and T. J. Hubin, Inorg. Chim. Acta, 2009, 362, 2084-8. doi: 10.1016/j.ica.2008.09.034 MRI contrast agent delivery using spore capsules: controlled release in blood plasma, M. Lorch, M. J. Thomasson, A. Diego-Taboada, S. Barrier, S. L. Atkin, G. Mackenzie, and S. J. Archibald, Chem. Commun., 2009, 6442-4. doi: 10.1039/b909551a CXCR4 Antagonists: A New Generation of Configurationally Restricted Bis-azamacrocyclic Compounds, A. Khan, G. Nicholson, G. McRobbie, J. Greenman, C. Pannecouque, D. Daelemans, D. Schols, E. De Clercq, T. J. Hubin, and S. J. Archibald, Antiviral Res., 2009, 82, 136. doi: 10.1016/j.antiviral.2009.02.141 Binding Optimization through Coordination Chemistry: CXCR4 Chemokine Receptor Antagonists from Ultrarigid Metal Complexes, A. Khan, G. Nicholson, J. Greenman, L. Madden, G. McRobbie, C. Pannecouque, E. De Clercq, R. Ullom, D. L. Maples, R. D. Maples, J. D. Silversides, T. J. Hubin, and S. J. Archibald, J. Am. Chem. Soc., 2009, 131, 3416-+. doi: 10.1021/ja807921k Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition metal silylamide complexes, F. Cheng, C. N. Hope, S. J. Archibald, J. S. Bradley, S. Clark, M. G. Francesconi, S. M. Kelly, N. A. Young, and F. Lefebvre, Int. J. Appld. Ceramic Technol., 2009, in press. doi: 10.1111/j.1744-7402.2009.02452.x CXCR4 Chemokine Receptor Antagonists from Ultra-rigid Metal Complexes Profoundly Inhibit HIV-1 Replication, and also AMD3100-resistant Strains, S. J. Archibald, D. Daelemans, T. J. Hubin, D. Huskens, D. Schols, K. Van Laethem, E. De Clercq, and C. Pannecouque, Antiviral Res., 2009, 82, 95. doi: 10.1016/j.antiviral.2009.02.100 Benz(2-heteroaryl) cyanoximes and their Tl(I) complexes: new room temperature blue emitters, O. T. Ilkun, S. J. Archibald, C. L. Barnes, N. Gerasimchuk, R. Biagioni, S. Silchenko, O. A. Gerasimchuk, V. N. Nemykin, and O. A. Gerasimchuke, Dalton Trans., 2008, 5715-29. doi: 10.1039/b803846e The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions, D. L. Cockriel, J. M. McClain, K. C. Patel, R. Ullom, T. R. Hasley, S. J. Archibald, and T. J. Hubin, Inorg. Chem. Commun., 2008, 11, 1-4. doi: 10.1016/j.inoche.2007.10.006 Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis, J. D. Silversides, C. C. Allan, and S. J. Archibald, Dalton Trans., 2007, 971-8. doi: 10.1039/b615329a Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists, G. McRobbie, G. C. Valks, C. J. Empson, A. Khan, J. D. Silversides, C. Pannecouque, E. De Clercq, S. G. Fiddy, A. J. Bridgeman, N. A. Young, and S. J. Archibald, Dalton Trans., 2007, 5008-18. doi: 10.1039/b705800d