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个人简介

教育背景 2012.08-2017.08 美国哥伦比亚大学,化学系,博士 2008.08-2011.05 美国爱荷华州立大学,化学系,硕士 2004.09-2008.06 武汉大学,化学与分子科学学院,本科 工作履历 2020.06至今 清华大学,化学系,副教授 2017.09-2019.12 美国哥伦比亚大学,化学系,博士后 奖励与荣誉 2017年 哥伦比亚大学化学系博士毕业生荣誉奖Hammett Award 2016年 国家优秀自费留学生奖学金特别优秀奖

研究领域

分子光谱和非线性光学成像,化学探针,生物光子学

近期论文

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Super-multiplex imaging of cellular dynamics and heterogeneity by integrated stimulated Raman and fluorescence microscopy J. Shou, R. Oda, F. Hu*, K. Karasawa, M. Nuriya, M. Yasui, B. Shiramizu, W. Min*, Y. Ozeki*, iScience, 24, 102832 (2021) 9-Cyanopyronin probe palette for super-multiplexed vibrational imaging Y. Miao, N. Qian, L. Shi, F. Hu, W. Min* , Nat. Commun., 12, 4518 (2021) Multiplexed live-cell profiling with Raman probes C. Chen, Z. Zhao, N. Qian, S. Wei, F. Hu, and W. Min*, Nat. Commun., 12, 3405 (2021). Ultra-bright Raman dots for multiplexed optical imaging Z. Zhao, C. Chen, S. Wei, H. Xiong, F. Hu, Y. Miao, T. Jin, and W. Min*, Nat. Commun., 12, 1305 (2021). Optical mapping of biological water in single live cells by stimulated Raman excited fluorescence microscopy L. Shi, F. Hu, and W. Min*, Nat. Commun., 10, 4764 (2019). Biological imaging of chemical bonds by stimulated Raman scattering microscopy F. Hu#, L. Shi#, and W. Min*,Nat. Methods, 16, 830-842 (2019). (# equal contribution) Structure–activity–distribution relationship study of anti-cancer antimycin-type depsipeptides J. Seidel, Y. Miao, W. Porterfield, W. Cai, X. Zhu, S. Kim, F. Hu, S. Bhattarai-Kline, W. Min*, W. Zhang*, Chem. Commun., 55, 9379-9382 (2019). Probe design for super-multiplexed vibrational imaging Y. Miao, L. Shi, F. Hu, and W. Min*, Phys. Biol., 16, 041003 (2019). Raman imaging of small biomolecules Y. Shen, F. Hu, and W. Min* ,Annu. Rev. Biophys. 48, 347-369 (2019). Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms K. T. Schiessl#, F. Hu#, J. Jo, S. Z. Nazia, B. Wang, A. Price-Whelan, W. Min* and L. E. P. Dietrich*, Nat. Commun., 10, 762 (2019). (# equal contribution) A ratiometric Raman probe for live-cell imaging of hydrogen sulfide in mitochondria by stimulated Raman scattering C. Zeng, F. Hu, R. Long, and W. Min*, Analyst, 143, 4844-4848 (2018). Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis M. M. Gaschler, F. Hu, H. Feng, A. Linkermann, W. Min*, and B. R. Stockwell*, ACS Chem. Biol., 13, 1013-1020 (2018). Supermultiplexed optical imaging and barcoding with engineered polyynes F. Hu#, C. Zeng#, R. Long, Y. Miao, L. Wei, Q. Xu, and W. Min*, Nat. Methods, 15, 194-200 (2018). (# equal contribution) Two-color vibrational imaging of glucose metabolism using stimulated Raman scattering R. Long, L. Zhang, L. Shi, Y. Shen, F. Hu, C. Zeng and W. Min*, Chem. Commun., 54, 152-155 (2018). Applications of vibrational tags in biological imaging by Raman microscopy Z. Zhao, Y. Shen, F. Hu, and W. Min*, Analyst, 142, 4018-4029 (2017). Stimulated Raman scattering of polymer nanoparticles for multiplexed live-cell imaging F. Hu#, S. D. Brucks#, T. H. Lambert, L. M. Campos* and W. Min*, Chem. Commun., 53, 6187-6190 (2017). (# equal contribution) Super-multiplex vibrational imaging L. Wei, Z. Chen, L. Shi, R. Long, A. V. Anzalone, L. Zhang, F. Hu, R. Yuste, V. W. Cornish and W. Min*, Nature, 544, 465-470 (2017). Bioorthogonal chemical imaging of metabolic activities in live mammalian hippocampal tissues with stimulated Raman scattering F. Hu, M. Lamprecht, L. Wei, B. Morrison* and W. Min*, Sci. Rep., 6, 39660, (2016). Live-cell bioorthogonal chemical imaging: stimulated Raman scattering microscopy of vibrational probes L. Wei, F. Hu, Z. Chen, Y. Shen, L. Zhang and W. Min* , Acc. Chem. Res., 49, 1494-1502 (2016). Macrosteres: the deltic guanidinium ion K. Mishiro, F. Hu, D. W. Paley, W. Min, T. H. Lambert* , Eur. J. Org. Chem., 2016, 1655-1659 (2016). Vibrational imaging of glucose uptake activity in live cells and tissues by stimulated Raman scattering F. Hu, Z. Chen, L. Zhang, Y. Shen, L. Wei and W. Min*, Angew. Chem. Int. Ed., 54, 9821-9825 (2015). Imaging complex protein metabolism in live organisms by stimulated Raman scattering microscopy with isotope labeling L. Wei, Y. Shen, F. Xu, F. Hu, J. Harrington, K. Targoff and W. Min*, ACS Chem. Biol., 10, 901-908 (2015). Live-cell quantitative imaging of proteome degradation by stimulated Raman scattering Y. Shen, F. Xu, L. Wei, F. Hu and W. Min* , Angew. Chem. Int. Ed., 53, 5596-5599 (2014). Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C.-C. Lin, M. Wang and W. Min* , Nat. Methods, 11, 410-412 (2014). Live cell vibrational imaging of choline metabolites by stimulated Raman scattering coupled with isotope-based metabolic labeling F. Hu, L. Wei, C. Zheng, Y. Shen and W. Min*, Analyst, 139, 2312-2317 (2014). Paramagnetic Cu(II) for probing membrane protein structure and function: inhibition mechanism of the influenza M2 proton channel Y. Su, F. Hu and M. Hong*, J. Am. Chem. Soc., 134, 8693-8702 (2012). Membrane protein structure and dynamics from NMR spectroscopy M. Hong*, Y. Zhang and F. Hu, Annu. Rev. Phys. Chem., 63, 1-24 (2012). NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel F. Hu, K. Schmidt-Rohr and M. Hong*, J. Am. Chem. Soc., 134, 3703-3713 (2012). Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2 J. Wang, C. Ma, G. Fiorin, V. Carnevale, T. Wang, F. Hu, R. A. Lamb, L. H. Pinto, M. Hong, M. L. Klein*, and W. F. DeGrado*, J. Am. Chem. Soc., 133, 12834-12841 (2011). Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding and membrane thickness F. Hu, W. Luo, S. D. Cady and M. Hong*, Biochim. Biophys. Acta Biomembranes, 1808, 415-423 (2011). Mechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMR F. Hu, W. Luo, and M. Hong* , Science, 330, 505-508 (2010). Structure and function of the influenza M2 proton channel S. D. Cady, W. Luo, F. Hu, and M. Hong* , Biochemistry, 48, 7356-7364 (2009).

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