夏若虹 - 华东师范大学 - 物理与电子科学学院

研究领域

钙释放通道蛋白的氧化还原机制研究离子通道蛋白自由巯基数量的估测和与门控状态间的关系探讨‚调控剂电子传递性质和对通道门控的调控性质间的关 GSH/GSSG和NADH/NAD+氧化还原电势对Ryanodine receptor （RyR）的氧化还原调控的作用氧化还原调控剂对通道的调控过程中的氧自由基的产生和作用机制硒和锌等微量元素对Ryanodine receptor的调控及其机制电磁场辐射对EGFR和insulin的信号转导机制的影响、对钙信号通路的影响‚与EGFR-细胞骨架信号通道的影响

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Michael J. Jurynec, Ruohong Xia , John J. Mackrill , Derrick Gunther, Thomas Crawford , Kevin M. Flanigan. Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proceedings of the National Academy of Sciences of the United State of America （PNAS）, 2008, 105(34): 12485–12490. Caili Jia, Zhenjie Zhou, Renchen Liu, Shude Chen, Ruohong Xia*. EGF receptor clustering is induced by a 0.4mT power frequency magnetic field and blocked by the EGF receptor tyrosine kinase inhibitor PD153035. Bioelectromagnetics. 2007.28（3）197-207. Li LJ, Dai YW, Xia RH, Chen S, Qiao D. Pulsed electric field exposure of insulin induces anti-proliferative effects on human hepatocytes. Bioelectromagnetics. 2005,(8):639-47. Ologo RO, Xia RH, Abramson JJ. Spectrophotometric and fluorometric assay of superoxide ionusing 4-Chloro-7- nitrobenzo-2-oxa-1,3-diazole. Analytical Biochemistry. 2005. 339 .338–344. Xia, Ruohong; Ganther, Howard E.; Egge, Adam; Abramson, Jonathan J. Selenium compounds modulate the calcium release channel/ryanodine receptor of rabbit skeletal muscle by oxidizing functional thiols. Biochem Pharmacol. 2004,Jun 1;67(11):2071-9. (SCI: 2.993). Xia, Ruohong, et al. Skeletal muscle sarcoplasmic reticulum contains a NADH dependent oxidase that generates superoxide. Am. J. Physiol. Cell Physiol. 2003, 285(1):C215-21 Xia, R, Chen, K., Ganther, H.E., Egge, A, Zhu, PH, and Abramson, J.J. Selenium containing compounds modulate the Ca2+ release mechanism/ ryanodine receptor of skeletal muscle sarcoplasmic reticulum. Biophys. J. 84, 109A (2003). (SCI: 4.463) Xia, Ruohong, et al. Skeletal muscle ryanodine receptor is a redox sensor with a well defined redox potential that is sensitive to channel modulators. J. Biol. Chem. 2000,275（47）36565－36561. Xiao-Fang Hu, Ke-Ying Chen, Ruohong Xia, et al. Modulation of the Interactions of Isolated Ryanodine Receptors of Rabbit Skeletal Muscle by Na+ and K+. Biochemistry 2003, 42, 5515-5521.. Xia, R., Gnall, L., Cutler, K., and Abramson, J.J. Skeletal Muscle Sarcoplasmic Reticulum Contains a NADH Dependent Oxidase that Generates Superoxide and Activates the Ryanodine Receptor. Biophys. J. 84, 18A (2003). (SCI: 4.463) Wang H, Zhu HF, Xia R, Zhou ZN, Zhu PH. Effect of intermittent and continuous hypoxia on ryanodine receptors of rat heart. Life Sci. 2003 Sep 12;73(17):2151-60. Xia, Ruohong, et al. Biphasic modulation of ryanodine binding to sarcoplasmic reticulum vesicles of skeletal muscle by Zn2+ ions. Biochem. J. 2000, 345, 279-286. (SCI: ) Wang, Hui; Chen, Keying; Xia, Ruohong; Zhu, Peihong. Inhibition of Ryanodine Binding to Sarcoplasmic Reticulum Vesicles of Cardiac Muscle by Zn2+ Ions. Cellular Physiology and Biochemistry 2001,11:83-92. Wei, Feng; Liu,Guohua; Xia, Ruohong; et al. Site-selective modification of hyperreactive cysteines of ryanodine receptor complex by quinones. Mol. Pharm. May 1999, 55(5): 821-831.