个人简介

born 1960 1986 Diplom (Chemistry), Freie Universität Berlin, Germany (J. Mulzer) 1991 Dr. sc. nat., ETH Zurich, Switzerland (S. A. Benner) 1993 Postdoc, Harvard University, Cambridge, USA (J. Knowles) 2000 Habilitation, Dortmund, Germany (R. S. Goody) since 2000 Professor of Organic Chemistry, Aachen, Germany

研究领域

Organische Chemie

The current research interest of Professor Elmar Weinhold and his coworkers is in the field of bioorganic chemistry. The research is focussed on the relationship between structure and activity of DNA-modifying enzymes, such as DNA methyltransferases. After incorporation of well designed modifications into the DNA substrate or the cofactor by organic synthesis and modification of the enzymes by molecular biology techniques, the results of these structural changes are analysed by various biochemical and biophysical methods and used for the design or selection of new catalytic properties and inhibitors. For example, the DNA methyltransferase M.TaqI catalyses the transfer of the activated methyl group from the cofactor S-adenosyl-L-methionine (1) to the amino group of adenine within the double-stranded 5'-TCGA-3' DNA sequence 2.

近期论文

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Enzymatically Incorporated Genomic Tags for Optical Mapping of DNA-Binding Proteins Kim, Soohong; Gottfried, Anna; Lin, Ron R.; Dertinger, Thomas; Kim, Andrew S.; Chung, Sangyoon; Colyer, Ryan A.; Weinhold, Elmar; Weiss, Shimon; Ebenstein, Yuval; Angew. Chem. Int. Ed. 2012, 51(15), 3578-3581. A Selenium-Based Click AdoMet Analogue for Versatile Substrate Labeling with Wild-Type Protein Methyltransferases Willnow, Sophie; Martin, Michael; Lüscher, Bernhard; Weinhold, Elmar; ChemBioChem 2012, 13(8), 1167-1173. Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases Tomkuvienė, Miglė; Clouet-d'Orval, Béatrice; Černiauskas, Ignas; Weinhold, Elmar; Klimašauskas, Saulius; Nucl. Acids Res. 2012, 40(14), 6765-73. Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling Motorin, Yuri; Burhenne, Jürgen; Teimer, Roman; Koynov, Kaloian; Willnow, Sophie; Weinhold, Elmar; Helm, Mark; Nucl. Acids Res. 2011, 39(5), 1943-1952. Sequence-specific covalent labelling of DNA Gottfried, Anna; Weinhold, Elmar; Biochem. Soc. Trans. 2011, 39, 623-628. Enzymatic Site-Specific Functionalization of Protein Methyltransferase Substrates with Alkynes for Click Labeling Peters, Wibke; Willnow, Sophie; Duisken, Mike; Kleine, Henning; Macherey, Thomas; Duncan, Kelly E.; Litchfield, David W.; Lüscher, Bernhard; Weinhold, Elmar; Angew. Chem. 2010, 49(30), 5170-5173. Synthesis of S-Adenosyl-L-homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases Dalhoff, Christian; Hüben, Michael; Lenz, Thomas; Poot, Peter; Nordhoff, Eckhard; Köster, Hubert; Weinhold, Elmar; ChemBioChem 2010, 11(2), 256-265. Targeted DNA Methylation by a DNA Methyltransferase Coupled to a Triple Helix Forming Oligonucleotide To Down-Regulate the Epithelial Cell Adhesion Molecule Van der Gun, Bernardina T. F.; Maluszynska-Hoffman, Maria; Kiss, Antal; Arendzen, Alice J.; Ruiters, Marcel H. J.; McLaughlin, Pamela M. J.; Weinhold, Elmar; Rots, Marianne G.; Bioconjugate Chem. 2010, 21(7), 1239-1245. Selective recognition of pyrimidine-pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators Bahr, Matthias; Gabelica, Valerie; Granzhan, Anton; Teulade-Fichou, Marie-Paule; Weinhold, Elmar; Nucleic Acids Res. 2008, 36(15), 5000-5012. 6-Thioguanine in DNA as CD-spectroscopic probe to study local structural changes upon protein binding Repges, Rudolph; Beuck, Christine; Weinhold, Elmar; Raabe, Gerhard; Fleischhauer, Jorg; Chirality 2008, 20(9), 978-984. Persistent down-regulation of the pancarcinoma-associated Epithelial Cell Adhesion Molecule via active intranuclear methylation Van der Gun, Bermadina T.F.; Wasserkort, Reinold; Monami, Amelie; Jeltsch, Albert; Rasko, Tamits; Slaska-Kiss, Krystyna; Cortese, Rene; Rots, Marianne G.; de Leij, Lou F.M.H.; Ruiters Marcel H.J.; Kiss, Antal; Weinhold, Elmar; McLaughlin, Pamela M.J.; Int. J. Cancer 2008, 123(2), 484-489. Enzyme-directed positioning of nanoparticles on large DNA templates Braun, Gary; Diechrierow, Michael; Wilkinson, Stephanie; Schmidt, Falk; Hüben, Michael; Weinhold, Elmar; Reich, Norbert O.; Bioconjugate Chem. 2008, 19(2), 476-479. Molecular scale architecture: engineered three- and four-way junctions Wilkinson, Stephanie; Diechtierow, Michael; Estabrook, R. August; Schmidt, Falk; Hüben, Michael; Weinhold, Elmar; Reich, Norbert O., Bioconjugate Chem. 2008, 19(2), 470-475. Sequence-specific Methyltransferase-Inducd Labelling (SMILing) of plasmid DNA for studying cell transfection Schmidt, Falk H.-G.; Hüben, Michael; Gider, Basar; Renault, Francois; Teulade-Fichou, Marie-Paule; Weinhold, Elmar, Bioorg. Med. Chem. 2008, 16(1), 40-48.