王昊 - 中央民族大学

个人简介

1978年出生，汉族，现为中央民族大学药学院教师。入选2017年度科技部创新人才推进计划：中青年科技创新领军人才。本课题组主要研究集中于新药先导化合物的发现、设计与评价，目前研究集中在抗耐药菌和抗组织纤维化的多靶点协同药物设计和调控蛋白-蛋白相互作用研究。本人主持国家自然科学基金3项，省级重点和人才项目2项，省部级一般项目4项。发表SCI论文30余篇，以第一发明人授权发明专利2项。个人主要学习工作经历 1997．9–2001．7 沈阳药科大学化学制药学士 2003．9–2007．7 英国诺丁汉大学计算化学博士 2007．9–2009．12 英国布里斯托大学药物设计博士后 2010．9-2019．10 宁夏医科大学药物化学副教授/教授 2013．3-2014．6 马来西亚大学高级访问学者 2019．10-至今中央民族大学教授

研究领域

本课题组主要研究集中于新药先导化合物的发现、设计与评价，目前研究集中在抗耐药菌和抗组织纤维化的多靶点协同药物设计和调控蛋白-蛋白相互作用研究

近期论文

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Wang, Hao; Chen, Meiling; Sang, Xiaohong; You, Xuefu; Wang, Yucheng; Paterson, Ian C; Hong, Wei*; Yang, Xinyi*, Development of small molecule inhibitors targeting TGF-β ligand andreceptor: Structures, mechanism, preclinical studies and clinical usage,Eur. J. Med. Chem., vol. 191, p. 112154, Apr. 2020. Wu, Han#; Sun, Yu#; Wong, Wee Lin#; Cui, Jiajia#; Li, Jingyang; You,Xuefu; Yap, Lee Fah; Huang, Yu; Hong, Wei*; Yang, Xinyi*; Paterson, Ian C*; Wang, Hao*; The development of a novel transforming growth factor-beta (TGF-beta)inhibitor that disrupts ligand-receptor interactions. , European Journal ofMedicinal Chemistry, 2020, 189: 112042. Hao Yang#, Yifan Ouyang#, Hao Ma, Hui Cong, Chunlin Zhuang, Wun-TaaiLok, Zhe Wang, Xuanli Zhu, Yutong Sun, Wei Hong*, Hao Wang*. Design and synthesis of novel PRMT1 inhibitors and investigation of their binding preferences using molecular modeling. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 4635-4642. Wei Hong, Jingyang Li, Zhe Chang, Xiaoli Tan, Hao Yang, Yifan Ouyang, Yanhui Yang, Sargit Kaur, Ian C Paterson, Yun Fong Ngeow and Hao Wang*. Synthesis and biological evaluation of indole core-based derivatives with potent antibacterial activity against resistant bacterial pathogens. The Journal of Antibiotics, 2017, 70(7): 832-844. Wei Hong, Yu Wang, Zhe Chang, Yanhui Yang, Jing Pu, Tao Sun, Sargit Kaur, James C Sacchettini, Hunmin Jung, Wee Lin Wong, Lee Fah Yap, Yun Fong Ngeow, Ian C Paterson, Hao Wang*. The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modeling. Scientific Reports, 2015, 5:15328. 15. Wei Hong, Jingyang Li, Charles A. Laughton, Lee Fah Yap, Ian C. Paterson, Hao Wang*. Investigating the binding preferences of small molecule inhibitors of humanprotein arginine methyltransferase 1 using molecular modeling. Journal of Molecular Graphics and Modelling, 2014, 51: 193-202. Hao Wang, Richard B. Sessions, Stephen S. Prime, Deborah K. Shoemark, Shelley J. Allen, Wei Hong, Sathya Narayanan, Ian C. Paterson*; Identification of novel small molecule TGF-β antagonists using structure-based drug design. Journal of Computer-Aided Molecular Design, 2013, 27: 365-372. Hao Wang*, Charles A. Laughton. The inhibitory effects of vinylphosphonate-linked thymidine dimers on the unidirectional translocation of PcrA helicase along DNA: A molecular modelling study. Physical Chemistry Chemical Physics, 2012, 14: 12230- 12237. Hao Wang, Charles A. Laughton*. Molecular modelling methods to quantitate Drug-DNA interactions. Drug-DNA Interaction Protocols, 2010 Humana Press ISBN: 978-1-60327-417-3. Hao Wang, Charles A. Laughton*. Evaluation of molecular modelling methods to predict the sequence-selectivity of DNA minor groove. Physical Chemistry Chemical Physics, 2009, 11: 10722-10728. Hao Wang, Charles A. Laughton. Molecular modelling methods for prediction of sequence-selectivity in DNA recognition. Methods, 2007, 42(2): 196-203.