个人简介
程金波,教授,理学博士(北京师范大学),硕士研究生导师,中央民族大学2019年高层次优秀人才,美国Sanford-Burnham医学研究所访问学者。担任北京神经科学学会青年委员会副主任委员,中国卒中学会转化分会常务委员,Frontiers in Pharmacology副主编,Journal of Neuroinflammation, Cellular Signaling, Mitochondrion等国际著名SCI期刊长期审稿人。
研究方向主要集中于重大神经系统疾病(神经退行性疾病、脑卒中、抑郁症等)的致病机制以及干预研究,以第一作者或通讯作者在Science Advances,Autophagy, Cell Death and Differentiation, Theranostic, Protein & Cell等国际著名期刊发表SCI论文30多篇,引用1000余次。主持国家自然科学基金面上项目3项(分别在2018年、2020年以及2022年获批)、青年基金项目1项,北京市自然基金面上项目1项、军队重大项目子课题2项等。
近期论文
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Jinbo Cheng*, Yuan Dong, Jun Ma, Ruiyuan Pan, Yajin Liao, Xiangxi Kong, Xiaoheng Li, Shuoshuo Li, Pingfang Chen, Liang Wang, Ye Yu, Zengqiang Yuan*. 2021. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology. Science Advances. 25;7(35):eabe3600. (IF: 14.9, SCI一区,第一作者兼共同通讯作者)
Jinbo Cheng*, Yajin Liao, Yuan Dong, Han Hu, Nannan Yang, Xiangxi Kong, Shuoshuo Li, Xiaoheng Li, Jifeng Guo, Lixia Qin, Jiezhong Yu, Cungen Ma, Jianke Li, Mingtao Li, Beisha Tang*, Zengqiang Yuan*. 2020. Microglial Autophagy Defect Causes Parkinson’s Disease-like Symptom by Accelerating Inflammasome Activation in Mice. Autophagy. 2193-2205. (IF: 16.0, SCI一区,第一作者兼共同通讯作者)
Jinbo Cheng, Yajin Liao, Lei Xiao, Rong Wu, Siqi Zhao, Shengyi Peng, Jun Ma, Hong Chen, Baidong Hou, Xia Zhang, Chengyu Liang, Yun Xu, Zengqiang Yuan. 2017. Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia. Cell Death and Differentiation. 24.276-287. (IF: 15.8, SCI一区,第一作者)
Yuan Dong, Shuoshuo Li, Yiming Lu, Xiaoheng Li, Yajin Liao, Zhixin Peng, Yunfeng Li, Lin Hou*, Zengqiang Yuan*, Jinbo Cheng*. 2020. Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice. Journal of Neuroinflammation. 17.205 (IF: 9.5, SCI一区,通讯作者)
Yajin Liao#, Jinbo Cheng#, Xiangxi Kong#, Shuoshuo Li , Xiaoheng Li , Meijuan Zhang , He Zhang , Tianli Yang , Yuan Dong , Jun Li , Yun Xu , Zengqiang Yuan*. 2020. HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway. Theranostics. 2020 Jul 29;10(21):9644-9662. (IF:11.5, SCI一区,共同第一作者)
Shuoshuo Li, Yajin Liao, Yuan Dong, Xiaoheng Li, Jun Li, Yong Cheng, Jinbo Cheng* and Zengqiang Yuan*. 2021. Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice. Journal of Neuroinflammation. 18.7 (IF: 9.5, SCI一区,共同通讯作者)
Cheng J*, Wang S, Dong Y and Yuan Z*. 2020. The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System. Front. Immunol. 11:281. doi: 10.3389/fimmu.2020.00281. (IF: 8.3,SCI二区,第一作者兼共同通讯作者)
YanM, Bo X, Zhang X, Zhang J, Liao Y, Zhang H, Cheng Y, Guo J* and Cheng J*. 2022. Mangiferin Alleviates Postpartum Depression–Like Behaviors by Inhibiting MAPK Signaling in Microglia. Front. Pharmacol. 13:840567. (IF: 5.8,SCI二区,通讯作者)
Liao Y, Dong Y and Cheng J*. 2020. The Molecular Determinants of Mitochondrial Membrane Contact with ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology. Front. Cell. Neurosci. 14:194. (IF: 5.5,SCI二区,通讯作者)
Xiaoheng Li, Yajin Liao, Yuan Dong, Shuoshuo Li, Fengchao Wang, Rong Wu, Zengqiang Yuan*, Jinbo Cheng* 2020. Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury. Aging and Disease. 11(3); 523-535. (IF: 6.7,SCI二区,通讯作者)
Yao R, Pan R, Shang C, Li X, Cheng J*, Xu J* and Li Y*. 2020. Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function. Front. Pharmacol. 11:986. (IF: 5.8,SCI二区,共同通讯作者)
Kong X, Liao Y, Zhou L, Zhang Y, Cheng J*, Yuan Z* and Wang S*. 2020. Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo. Front. Pharmacol. 11:581011. (IF: 5.8,SCI二区,共同通讯作者)
Lujun Zhou, Qiang Zhang, Peng Zhang, Zengqiang Yuan*, Jinbo Cheng* 2017. c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death. Cell Death and Disease. Oct 12;8(10):e3117 . (IF: 8.4,SCI二区, 通讯作者)
Jinbo Cheng, Yajin Liao, Lujun Zhou, Shengyi Peng, Hong Chen, Zengqiang Yuan. 2016. Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop. Scientific Reports. Feb 19; 6: 20158. (IF: 4.3,SCI二区,第一作者)
Yajin Liao, Yumin Hao, Hong Chen, Qing He, Zengqiang Yuan*, Jinbo Cheng*. 2015. Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death. Protein & Cell. 6, 434-442.(IF: 14.8,SCI二区, 通讯作者)
Yuan Dong, Xiaoheng Li, Jinbo Cheng*, Lin Hou*. 2019. Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target. International Journal of Molecular Sciences. Jan 28;20(3). pii: E558.(SCI三区, 共同通讯作者)
Yajin Liao, Yuan Dong, Jinbo Cheng*. 2017. The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders. International Journal of Molecular Sciences. 18. 248.(SCI三区, 通讯作者)
Xiangxi Kong, Zengqiang Yuan*, Jinbo Cheng*. 2016. The function of NOD-like receptors in central nervous system diseases. Journal of Neuroscience Research. 28. doi: 10.1002/jnr.24004.(SCI三区, 通讯作者)
Jinbo Cheng, Wei Tang, Zhenyi Su, Junxia Guo, Li Tong and Qun Wei. 2012. Calcineurin subunit B promotes TNF-ɑ-induced apoptosis by binding to mitochondria and causing mitochondrial Ca2+ overload. Cancer Letters. 321(2), 169-178. (IF: 8.6,SCI一区,第一作者)
Jinbo Cheng, Wei Tang, Zhenyi Su, Qun Wei. 2011. Mutation of calcineurin subunit B M118 influences the activities of NF-AT and p53, but not calcineurin expression level. Biochemical and Biophysical Research Communications. Sep 30;413(3):481-6. (SCI三区,第一作者)