林世贤 - 浙江大学 - 生命科学研究院

个人简介

教育和工作经历 2005-2009　　武汉大学化学与分子科学学院，学士（化学生物学） 2009-2014 北京大学化学与分子工程学院，博士（化学生物学） 2014-2017 加州大学伯克利分校化学学院，博士后（化学生物学） 2017.12- 浙江大学生命科学研究院研究员、博士生导师个人和学术荣誉 2009 武汉大学优秀毕业生 2011 教育部学术新人奖 2013 研究生国家奖学金 2014 北京大学优秀毕业生，优秀毕业论文 2014 北京市优秀毕业生 2018 浙江省特聘专家 2019 国家青年人才计划 2019 教育部自然科学一等奖（第五） 2021 国家自然科学二等奖（第五） 2022 ACS Chemical Biology Young Investigator Special Issue 2022 国家优青 2022 国际化学生物学学会“Young Chemical Biologist Awards”

研究领域

化学生物学生命科学的发展，离不开与化学、物理学、数学等基础科学和工程技术领域的交叉和融合，其他学科带来的理论和技术是生命科学发展的动力和源泉。同时，生命科学也为这些基础科学的研究提出了新的研究方向。本实验在关注重大疾病和罕见遗传病科学问题的同时，非常注重培养学生的交叉学科思维方式和技能。在本实验室既可以学习到细胞生物学，生物化学，分子生物学等传统生物学技能，还有机会深入接触化学生物学，合成生物学等交叉学科的新式研究技能，体会交叉学科的研究思想。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Ding W, Liu C, Chen Y, Gu J, Fang C, Hu L, Zhang L, Yuan Y, Feng X-H, Lin S*. “Computational design and genetic incorporation of lipidation mimics in living cells”, Nat. Chem. Biol., 2023, accepted. Zhao H, Tang L, Fang Y, Liu C, Ding W, Zang S, Chen Y, Xu W, Yuan Y, Fang D, Lin S*. “Manipulating cation-π interactions of reader proteins in living cells with genetic code expansion”, J. Am. Chem. Soc., 2023, 10.1021/jacs.3c02293. Dai T, Zhang L, Ran Y, Zhang M, Yang B, Lu H, Lin S*, Zhang L*, Zhou F*. “DeSUMOylation by SENP1 inhibits LLPS of MAVS and antagonizes IRF3 activation in innate antiviral immunity”, Nat. Struct. Mol. Biol., 2023, 30, 785-799. Chen P, Lin S, Li J. Genetic code expansion (Chapter 15). In “Advanced Chemical Biology” (H. C. Hang, M. R. Pratt, and J. A. Prescher, Eds.) Wiley-VCH, Weinheim, Germany, 2023, pp. 359-386. Zang J, Chen Y, Liu C, Hu L, Zhao H, Ding W, Yuan Y, Lin S*. “Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W”, Nat. Struct. Mol. Biol., 2023, 30, 62-71. Zang J, Chen Y, Liu C, Lin S*. “Probing the role of aurora kinase A threonylation with site-specific lysine threonylation”, ACS Chem. Biol., 2023, 18, 674-678. (Invited article for: ACS Chemical Biology Young Investigators Special Issue) Zhao H, Liu C, Ding W, Tang L, Fang Y, Chen Y, Hu L, Yuan Y, Fang D, Lin S*. “Manipulating cation-π interactions with genetically encoded tryptophan derivatives”, J. Am. Chem. Soc., 2022, 144, 6742-6748. Zhao H, Ding W, Zang J, Yang Y, Liu C, Hu L, Chen Y, Liu G, Fang Y, Yuan Y, Lin S*. “Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction”, Nat. Commun., 2021, 12, 7039. Ding W, Zhao H, Chen Y, Zhang B, Yang Y, Zang J, Wu J, Lin S*. “Chimeric design of pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion”, Nat. Commun., 2020, 11, 3154. Zang J, Chen Y, Zhu W, Lin S*. “Chemoselective methionine bioconjugation on a polypeptide, protein, and proteome”, Biochemistry., 2020, 59, 132-138. (Invited review article for Future of Biochemistry: The Asia-Pacific Issue) Zhu X, Su Q, Xie H, Song L, Yang F, Zhang D, Wang B, Lin S, Huang J, Wu M, Liu T. “SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition”, Nat. Chem. Biol., 2023, 19, 585-595. Qin Z, Fang X, Sun W, Ma Z, Dai T, Wang S, Zong Z, Huang H, Ru H, Lu H, Yang B, Lin S, Zhou F, Zhang L. “Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity”, Nat. Immunol., 2022, 23, 1193-1207. Zhang Z, Fang X, Wu X, Ling L, Chu F, Li J, Wang S, Zang J, Zhang B, Ye S, Zhang L, Yang B, Lin S, Huang H, Wang A, Zhou F. “Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity”, Mol. Cell., 2020, 79, 304-319. Liu X, Xiao W, Zhang Y, Wiley SE, Zuo T, Zheng Y, Chen N, Chen L, Wang X, Zheng Y, Huang L, Lin S, Murphy AN, Dixon JE, Xu P, Guo X. “Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function”, Proc. Natl. Acad. Sci. U S A., 2020, 117, 328-336. Zhang M, Liang C, Chen Q, Yan H, Xu J, Zhao H, Yuan X, Liu J, Lin S, Lu W, Wang F. “Histone H2A phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability”, EMBO. J., 2020, 39, e101863. Lin S#, Yang X#, Jia S, Weeks AM, Hornsby M, Lee PS, Nichiporuk RV, Iavarone AT, Wells JA, Toste FD, Chang CJ. “Redox-based reagents for chemoselective methionine bioconjugation”, Science, 2017, 355, 597-602. Lin S, Chen PR. “Fighting HIV at its own game”, Nat. Chem., 2014, 6, 566-568. News and Views Lin S, He D, Long T, Zhang S, Meng R, Chen PR. “Genetically encoded cleavable protein photo-cross-linker”, J. Am. Chem. Soc., 2014, 136, 11860-11863. Lin S#, Yan H#, Li L, Yang M, Peng B, Chen S, Li W, Chen PR, “Site-specific engineering of chemical functionalities on the surface of live hepatitis D virus”, Angew. Chem. Int. Ed., 2013, 52,13970-13974. Lin S, Zhang Z, Xu H, Li L, Chen S, Li J, Hao Z, Chen PR, “Site-specific incorporation of photocrosslinker and bioorthogonal amino acids into enteric bacterial pathogens”, J. Am. Chem. Soc., 2011, 133, 20581-20587. Zhang M#, Lin S#, Song X, Liu J, Fu Y, Ge X, Fu X, Chang Z, Chen PR, “A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance”, Nat. Chem. Biol., 2011, 7, 671-677. Cover Zheng H, Lin S, Chen PR. “Genetically encoded protein labeling and crosslinking in living Pseudomonas aeruginosa.”, Bioorg. Med. Chem., 2020, 28, 115545. Zheng H, Lin S, Chen PR. “Genetic code expansion in enteric bacterial pathogens.”, Methods. Mol. Biol., 2018, 1728, 113-126. Yang Y, Song H, He D, Zhang S, Dai S, Xie X, Lin S, Hao Z, Zheng H, Chen PR. “Genetically encoded releasable photo-cross-linking strategies for studying protein-protein interactions in living cells.”, Nat. Protoc., 2017, 12, 2147-2168. Zhang S, He D, Yang Y, Lin S, Zhang M, Dai S, Chen PR, “Comparative proteomics reveal distinct chaperone–client interactions in supporting bacterial acid resistance”, Proc. Natl. Acad. Sci. U S A., 2016, 113, 10872-10877. Yang Y, Song H, He D, Zhang S, Dai S, Lin S, Meng R, Wang C, Chen PR, “Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label”, Nat. Commun., 2016, 7, 12299.