Hu, Xiaoran - Syracuse University - Department of Chemistry

个人简介

Xiaoran grew up in Henan province in China and received a B.S. from Nanjing University. During his doctoral studies with Prof. Samuel Thomas at Tufts, Xiaoran developed strategies to control the self-assembly of polymers using light. Xiaoran then conducted his postdoc research in polymer mechanochemistry at Caltech, mentored by Prof. Maxwell Robb. After that, Xiaoran joined Profs. Shaoyi Jiang and Geoffrey Coates's groups at Cornell, where Xiaoran focused his efforts on the design, synthesis, and understanding of lipids and polymers for gene delivery. Xiaoran joined the faculty at Syracuse University in 2022. Education 2022 Postdoc Meinig School of Biomedical Engineering & Dept of Chemistry and Chemical Biology, Cornell 2021 Postdoc Division of Chemistry & Chemical Engineering, California Institute of Technology 2017 Ph.D. in Chemistry, Tufts University 2010 B.Sc. in Chemistry, Nanjing University Honors and Awards 2019 ACS PMSE Distinguished Poster Nominee 2018 Finalist, ACS Eastman Chemical Student Award in Applied Polymer Science 2016 Tufts Graduate Student Research Competition Award 2016 Graduate Research Excellence at Tufts Fellowship 2016 Tufts Graduate Student Travel Award

研究领域

Stimuli-Responsive Materials: We are interested in designing, synthesizing, and applying novel photoswitches and mechanophores. Responsive Nanomedicines: Our group is interested in developing nanomaterials that undergo preprogrammed structure and property changes in response to physical, chemical, and biological stimuli as next-generation drug delivery systems to maximize therapeutic efficacy and safety.

近期论文

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Husic, C. C.; Hu, X; Robb, M. J. “Incorporation of a Tethered Alcohol Enables Efficient Mechanically Triggered Release in Aprotic Environments”, ACS Macro Lett. 2022, 11, 948-953. Versaw, B; Zeng, T; Hu, X; Robb, M. J. “Harnessing the Power of Force: Development of Mechanophores for Molecular Release”, J. Am. Chem. Soc. 2021, 143, 21461-21473. Zeng, T; Hu, X; Robb, M. J. “5-Aryloxy Substitution Enables Efficient Mechanically Triggered Release from a Synthetically Accessible Masked 2-Furylcarbinol Mechanophore”, Chem. Commun., 2021, 57, 11173-11176. Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Release of Functionally Diverse Molecular Payloads from Masked 2-Furylcarbinol Derivatives”, ACS Cent. Sci. 2021, 7, 1216-1224. doi.org/10.1021/acscentsci.1c00460 Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Small Molecule Release from a Masked Furfuryl Carbonate”, J. Am. Chem. Soc. 2019, 141, 15018-15023. doi.org/10.1021/jacs.9b08663 Barber, R. W.; McFadden, M. E.; Hu, X.; and Robb, M. J. “Mechanochemically Gated Photoswitching: Expanding the Scope of Polymer Mechanochromism”, Synlett 2019, 30, 1725–1732. Hu, X.; McFadden, M. E.; Baber, R. W.; Robb, M. J. “Mechanochemical Regulation of a Photochemical Reaction”, J. Am. Chem. Soc. 2018, 140, 14073-14077. doi.org/10.1021/jacs.8b09628 Feeney M. J.; Hu, X.; Srinivasan R.; Van N.; Hunter M.; Georgakoudi I.; Thomas S. W. III “UV and NIR-Responsive Layer-by-Layer Films Containing 6-Bromo-7-hydroxycoumarin Photolabile Groups”, Langmuir 2017, 33, 10877–10885. Hu, X.; Lawrence, J. A.; Mullahoo, J.; Smith, Z. C; Wilson, D. J.; Mace, C. R.; Thomas, S. W. III “Directly Photopatternable Polythiophene as Dual-Tone Photoresist”, Macromolecules 2017, 50, 7258–7267. doi.org/10.1021/acs.macromol.7b01208 Kaner, P.; Hu, X.; Thomas, S. W. III, Asatekin, A. “Self-Cleaning Membranes from Comb-Shaped Copolymers with Photoresponsive Side Groups”, ACS Appl. Mater. Interfaces 2017, 9, 13619–13631. Hu, X.; Qureishi, Z.; Thomas, S. W. III "Light-Controlled Selective Disruption, Multi-Level Patterning, and Sequential Release with Polyelectrolyte Multilayer Films Incorporating Four Photocleavable Chromophores”, Chem. Mater. 2017, 29, 2951-2960. doi.org/10.1021/acs.chemmater.6b05294 Hu, X.; Feeney, M. J.; McIntosh, E.; Mullahoo, J.; Jia, F.; Xu, Q.; Thomas, S. W. III "Triggered Release of Encapsulated Cargo from Photoresponsive Polyelectrolyte Nanocomplexes", ACS Appl. Mater. Interfaces 2016, 8, 23517–23522. doi.org/10.1021/acsami.6b07366 Hu, X.; Macintosh, E; Simon, M. G.; Staii, C.; Thomas, S. W. III "Stimuli-Responsive Free-Standing Layer-By-Layer Films", Adv. Mater. 2016, 28, 715–721. doi.org/10.1002/adma.201504219 Hu, X.; Shi, J.; Thomas, S. W. III "Photolabile ROMP Gels Using ortho-Nitrobenzyl Functional Crosslinkers”, Polym. Chem. 2015, 6, 4966–4971. doi.org/10.1039/C5PY00562K Gumbley, P.; Hu, X.; Lawrence, J. A., III; Thomas, S. W. III "Photoresponsive Gels Prepared by Ring Opening Metathesis Polymerization”, Macromol. Rapid Commun. 2013, 34, 1838–1843.