Enders, Dieter - RWTH Aachen University

个人简介

1946 born in Butzbach/Hessen 1972 Diplom, Giessen/Deutschland (D. Seebach) 1974 Dr. rer. nat., Giessen/Deutschland (D. Seebach) 1974 - 1975 Postdoc Harvard University/USA (E.J. Corey) 1979 Habilitation, Giessen/Germany 1979 - 1980 Lecturer, Giessen/Germany 1980 - 1985 Professor of Organic Chemistry, Bonn seit 1985 Full Professor of Organic Chemistry and Director, Aachen/Germany 1994 - 2005 Speaker of the Sonderforschungsbereich 380 (DFG) "Asymmetric Synthesis with Chemical and Biological Methods" (RWTH Aachen, Research Center Jülich, Heinrich-Heine-University Düsseldorf, University of Bonn) 1998 - 2001 Speaker of the Transferbereich 11 (DFG) "Stereoselective Synthesis of Bioactive Compounds" 2008 - 2014 Member of the Senate of the German Research Foundation (DFG)

研究领域

Die aktuellen Forschungsgebiete von Professor Dieter Enders und seinen Mitarbeitern konzentrieren sich auf das generelle Gebiet der Organischen Synthese. Hauptarbeitsgebiete sind dabei die Entwicklung von Methoden zur hoch stereoselektiven Bindungsknüpfung und deren Anwendung in der Synthese von Natur- und Wirkstoffen. Zentrales Thema aller Forschungsaktivitäten ist dabei die Asymmetrische Synthese. In aktuellen Projekten werden dabei die diastereo- and enantioselektive Knüpfung von Kohlenstoff-Kohlenstoff- und Kohlenstoff-Heteroatom-Bindungen unter Verwendung von Hydrazonen, Aminonitrilen, Enaminen, α-silylierten Enolatderivaten, Lactamen, Sulfonamiden und Sulfonsäureestern bearbeitet [1]. Den Schwerpunkt bildet die Entwicklung von organokatalytischen Verfahren unter Verwendung von Aminosäurederivaten auf Prolin-Basis [4] sowie die Entwicklung von effektiven Carben-Katalysatoren [6] und deren Einsatz in der Organokatalyse. Besonders erwähnenswert ist hierbei zum einen die Entwicklung von Methoden zur Darstellung von Kohlenhydraten, Aminozuckern, Carbazuckern [4], Sphingolipiden [7] und der Entwicklung von Domino-Reaktionen [8]. Speziell das Forschungsgebiet der Domin-Reaktionen wird durch den ERC-Advanced Grant des European Research Council (ERC) gefördert.

近期论文

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Y. Zhi, K. Zhao, C. von Essen, K. Rissanen, D. Enders, Synlett 2017, 28, 2876 - 2880. Thiourea-Catalyzed Domino Michael-Mannich[3+2]Cycloadditions: A Strategy for the Asymmetric Synthesis of 3,3‘-Pyrrolidinyl-dispirooxindoles. S. Li, X.-Y. Chen, Q. Liu, A. Peuronen, K. Risanen, D. Enders, Synthesis 2017, 49, 4861 - 4868. N-Heterocyclic Carbene-Catalyzed Activation of α-Chloro-aldehydes: Asymmetric Synthesis of 5-Cyano-Substituted Dihydropyranones. F. Vetica, S. Bailey, P. Chauhan, M. Turberg, A. Ghaur, G. Raabe, D. Enders, Adv.Synth. Catal. 2017, 359, 3729 - 3734. Desymmetrization of Cyclopentendiones via Organocatalytic Cross-Dehydrogenative Coupling. X.-Y. Chen, S. Li, H. Sheng, Q. Liu, E. Jafari, C. von Essen, K. Rissanen, D.Enders, Chem. Eur. J. 2017, 23, 13042 - 13045. N-Heterocyclic Carbene Catalyzed [3+2]Cycloaddition of Enals with Masked Cinnamates for the Asymmetric One-Pot Synthesis of Adipic Acid Derivatives. P. Chauhan, S. Mahajan, D. Enders, Acc.Chem. Res. 2017, 50, 2809 - 2821.Achieving Molecular Complexity via Stereoselective Multiple Domino Reactions Promoted by a Secondary Amine Organocatalyst. Q. Liu, X.-Y. Chen, S. Li, E. Jafari. G. Raabe, D. Enders, Chem. Commun. 2017,53, 11342 - 11344. N-Heterocyclic Carbene Catalyzed [4+2]Annulation of β-Methyl Enals and Cyclic Trifluoromethyl Ketimines for the Asymmetric Synthesis of Dihydroquinazolinone Derivatives.59 U. Kaya, P. Chauhan, S. Mahajan, K. Deckers, A. Valkonen, K. Rissanen, D.Enders, Angew. Chem. 2017, 129, 15560 – 15564; Angw. Chem. Int. Ed. 2017, 56,15358 - 15362. Asymmetric Squaramide Catalyzed Domino aza-FriedelCrafts/N,O-Acetalization Reactions Between Naphthols and Pyrazolinone Ketimines. Q. Liu, X.-Y. Chen, S. Li, F. Vetica, G. Raabe, D. Enders, Synthesis 2018, 50, 127 -133. Two-Step Synthesis of α,β- Unsaturated γ-Amino Acid Esters via NHeterocyclic Carbene Catalyzed [4+2]Cycloadditions of Enals and Nitroso Compounds. K. Zhao, Y. Zhi, A. Wang, D. Enders, Synthesis. 2018, 50, accepted. Synthesis of Malononitrile-Substituted Diarylmethines via 1,6-Addition of Masked Acyl Cyanides to para-Quinone Methides. E. Jafari, D. S. Kundu, P. Chauhan, V. P. Reddy Gajulapalli, C. von Essen, K.Rissanen, D. Enders, Synthesis 2018, 50, 323 - 329. Organocatalytic Enantioselective Vinylogous Henry Reaction of 3,5-Dimethyl-4-Nitroisoxazole with Trifluoromethyl Ketones. X.-Y. Chen, J. Xiong, Q. Liu, S. Li, H. Sheng, C. von Essen, K. Rissanen, D.Enders, Angew. Chem. 2018, 130, 306 - 310; Angew. Int. Ed. 2018, 57, 300 - 304. Control of N-Heterocyclic Carbene Catalyzed Reactions of Enals: Asymmetric Synthesis of Oxindole-γ-Amino Acid Derivatives. X.-Y. Chen, Q. Liu, P. Chauhan, D. Enders, Angew. Chem. 2018, accepted. NHeterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Enantioselective Remote Functionalizations. Q. Li, K. Zhao, A. Peuronen, K. Rissanen, D. Enders, Y. Tang, J. Am. Chem. Soc.2018, accepted. Enantioselelctive Total Syntheses of (+)-Hippolachnin A, (+)-Gracilioether A, (−)-Gracilioether E and (−)-Gracilioether F. F. Vetica, P. Chauhan, S. Mahajan, G. Raabe, D. Enders, Synthesis 2018, 50,accepted. Asymmetric Organocatalytic Friedel-Crafts Hydroxyalkylation of Indoles Using Electrophilic Pyrazole-4,5-diones. S. Li, X.-Y. Chen, H. Sheng, C. von Essen, K. Rissanen, D. Enders, Synthesis 2018,50, accepted. N-Heterocyclic Carbene Catalyzed Asymmetric Synthesis of Dihydropyranothiazoles via Azolium Enolate Intermediates.60 E. Jafari, P. Chauhan, M. Kumar, X.-Y. Chen, S. Li, C. von Essen, K. Rissanen, D.Enders, Eur. J. Org. Chem. 2018, submitted. Organocatalytic Asymmetric Synthesis of Trifluoromethylated Tetrahydrocarbazoles via a Vinylogous Michael/Aldol Formal [4+2] Annulation. X.-C. Chen, D. Enders, Chem. 2018, 4, accepted. Multisubstituted Unnatural Prolines for Asymmetric Catalytic Domino Reactions. L. Zhao, L. Wang, S. Li, G. Raabe, D. Enders, Synthesis 2018, 50, submitted.Asymmetric Synthesis of Cyclopenta[c]quinoline Derivatives via N-Heterocyclic Carbene Catalyzed 1,4- and 1,2-Addition Domino Reactions. Y. Zhi, K. Zhao, C. von Essen, K. Rissanen, D. Enders, Org. Chem. Frontiers 2018,submitted. Synthesis of trans-2,3-Dihydrobenzofurans by a Formal [4+1]Annulation Between para-Quinone Methides and Sulfonium Salts. M. Kumar, P. Chauhan, S. J. Bailey, E. Jafari, C. von Essen, K. Rissanen, D.Enders, Org.Lett. 2018, 20, submitted. Organocatalytic OxaMichael/Michael/Michael/Aldol Condensation Quadruple Domino Sequence:Asymmetric Synthesis of Tricyclic Chromanes.