章海燕 - 中国科学院上海药物研究所 -

个人简介

教育经历 09/1994 – 07/1998 浙江杭州大学（现浙江大学），生化与微生物专业，学士 09/1998 – 07/2003 中国科学院上海药物研究所，神经药理专业，博士工作经历 08/2003 – 03/2005 美国Mayo Clinic医学研究所Jacksonville分所，博士后 04/2005 – 02/2007 美国Wake Forest大学，生理与药理系，博士后 02/2007 – 06/2009 中国科学院上海药物研究所，副研究员、研究员 06/2009 – 至今中国科学院上海药物研究所，研究员、课题组长

研究领域

主要从事阿尔采末症（Alzheimer’s disease）、血管性痴呆（Vascular dementia）以及缺血性脑卒中的发病机制和治疗策略研究。近年来致力于开展针对胆碱能系统缺损假说的关键问题—— “胆碱能系统昼夜节律需求”、“乙酰胆碱酯酶抑制剂病患亚群反应差异性和外周胆碱能不良反应普遍性”和针对Aβ级联反应假说的核心理论——“Aβ寡聚体毒性”、 “细胞内及细胞器内Aβ毒性”的抗痴呆药物新靶标发现和创新药物研究，以及针对缺血性脑卒中开展新型活性天然产物和SIRT、PSD95-nNOS等靶向型药物研究。

近期论文

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GuoXJ, Tian XS, Ruan Z, Chen YT, Wu L, Gong Q, Wang W, Zhang HY*. Dysregulation of Neurotrophic and Inflammatory Systems Accompanied by Decreased CREB Signaling in Ischemic Rat Retina. Exp Eye Res 2014 Jun 19;125C:156-163. Tian XS, GuoXJ, Ruan Z, Lei Y, Chen YT, Wu L, Gong Q, Wang W, Zhang HY*. Long-term vision and non-vision dominant behavioral deficits in the 2-VO rats are accompanied by time and regional glial activation in the white matter. PLos one 2014 Jun 26;9(6):e101120. Huang XT, Qian ZM, He X, Gong Q, Wu KC, Jiang LR, Lu LN, Zhu ZJ, Zhang HY, Yung WH, Ke Y. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiol Aging. 2014; 35: 1045-54. Tao YM, Fang L, Yang YM, Jiang HL, Yang HY, Zhang HY*, Zhou H*. Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastomaN2a cells. Proteomics. 2013; 13(8): 1314-24. Xing WQ, Fu Y, Shi ZX, Lu D, Zhang HY*, Hu YH*. Discovery of novel 2,6-disubstitutedpyridazinone derivatives as acetylcholinesterase inhibitors. Eur J Med Chem. 2013; 63: 95-103. ZouYQ, Xu L, Chen WY, Zhu YP, Chen TT, Fu Y, Li L, Ma LP, Xiong B, Wang X, Li J, He JH, Zhang HY*, Xu YC*, Li J*, Shen JK*. Discovery of pyrazole as C-terminus of selective BACE1 inhibitors. Eur J Med Chem. 2013; 68: 270-83. Zhang B, Tang XC, Zhang HY*. Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models. J Neurosci Res. 2013; 91(5): 717-25. GuoXJ, Chen YT, Liu QF, Wu J, Wang LY, Tang XC, Zhao WM*, Zhang HY*. Ac-cel, a novel antioxidant, protects against hydrogen peroxide-induced injury in PC12 cells via attenuation of mitochondrial dysfunction. J MolNeurosci. 2013; 50(3): 453-61. Wang LY, Wu J, Yang Z, Wang XJ, Fu Y, Liu SZ, Wang HM, Zhu WL, Zhang HY*, Zhao WM*. (M)- and (P)-bicelaphanol A, dimerictrinorditerpenes with promising neuroprotective activity from Celastrusorbiculatus. J Nat Prod. 2013; 76: 745-9. Wang XJ, Wang LY, Fu Y, Wu J, Tang XC, Zhao WM, Zhang HY*. Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimericpodocarpane type trinorditerpene isolated from Celastrusorbiculatus. Phytomedicine. 2013; 20(12):1064-70. Liang LF, Wang XJ, Zhang HY, Liu HL, Li J, Lan LF, Zhang W, GuoYW. Bioactive polyhydroxylated steroids from the Hainan soft coral SinulariadepressaTixier-Durivault. Bioorg Med ChemLett. 2013; 23(5): 1334-7. Tang Y, Fu Y, Xiong J, Li M, Ma GL, Yang GX, Wei BG, Zhao Y, Zhang HY, Hu JF. Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrumcasuarinoides. J Nat Prod. 2013; 76(8): 1475-84. Yang L, Ye CY, Huang XT, Tang XC, Zhang HY*. Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A. J Alzheimers Dis. 2012; 31(1): 131-42. Gao X, Zheng CY, Qin GW, Tang XC, Zhang HY*. S-52, a novel nootropic compound, protects against β-amyloid induced neuronal injury by attenuating mitochondrial dysfunction. J Neurosci Res. 2012; 90(10): 1981-8. Wang Y, Tang XC, Zhang HY*. Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice. J Neurosci Res. 2012; 90: 508-17. Zhang HY*. New insights into huperzine A for the treatment of Alzheimer's disease. ActaPharmacol Sin. 2012; 33: 1170-5. Jiang CS, GuoXJ, Gong JX, Zhu TT, Zhang HY*, GuoYW. Synthesis and biological evaluation of 21-arylidenepregnenolone derivatives as neuroprotective agents. Bioorg Med ChemLett. 2012; 22: 2226-9. Chen BE, Ye F, Yu L, JiaGF, Huang XT, Zhang XJ, Peng SY, Chen K, Wang MN, Gong SZ, Zhang RH, Yin JY, Li HY, Yang YM, Liu H, Zhang JW, Zhang HY, Zhang A, Jiang HL, Luo C, Yang CG. Development of Cell-Active N(6)-Methyladenosine RNA DemethylaseFTO Inhibitor. J Am Chem Soc. 2012; 134: 17963-71. Dong K, Pu JX, Zhang HY, Du X, Li XN, Zou J, Yang JH, Zhao W, Tang XC, Sun HD. Dibenzocyclooctadienelignans from Kadsurapolysperma and their antineurodegenerative activities. J Nat Prod. 2012; 75: 249-56. Yao LG, Zhang HY, Liang LF, GuoXJ, Mao SC, GuoYW. Yalongenes A and B, Two New Cembranoids with Cytoprotective Effects from the Hainan Soft Coral SarcophytontrocheliophrumMarenzeller. Helv. Chim. Acta. 2012; 95: 235-9.

学术兼职

中国药理学会老年痴呆专业委员会理事中国药理学报编委 Journal of Alzheimer’s disease编委